Publication Date:
2014-09-06
Description:
Correlations between sequence evolution and structural dynamics are of utmost importance in understanding the molecular mechanisms of function and their evolution. We have integrated Evol , a new package for fast and efficient comparative analysis of evolutionary patterns and conformational dynamics, into ProDy , a computational toolbox designed for inferring pro tein dyn amics from experimental and theoretical data. Using information-theoretic approaches, Evol coanalyzes conservation and coevolution profiles extracted from multiple sequence alignments of protein families with their inferred dynamics. Availability and implementation: ProDy and Evol are open-source and freely available under MIT License from http://prody.csb.pitt.edu/ . Contact: bahar@pitt.edu
Print ISSN:
1367-4803
Electronic ISSN:
1460-2059
Topics:
Biology
,
Computer Science
,
Medicine
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