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  • Articles  (3)
  • Nature Publishing Group (NPG)  (3)
  • American Chemical Society (ACS)
  • Oxford University Press
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  • 2010-2014  (3)
  • 2000-2004
  • 2014  (3)
  • Natural Sciences in General  (3)
  • Nature of Science, Research, Systems of Higher Education, Museum Science
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  • Articles  (3)
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  • 1
    Publication Date: 2014-02-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Porter, John R -- Wratten, Steve -- England -- Nature. 2014 Feb 20;506(7488):295. doi: 10.1038/506295a.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉University of Copenhagen, Denmark. ; Lincoln University, New Zealand.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24553231" target="_blank"〉PubMed〈/a〉
    Keywords: Gross Domestic Product/*trends ; Humans ; *Quality of Life ; Sociology/*methods
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 2
    Publication Date: 2014-12-18
    Description: Interventions that delay ageing mobilize mechanisms that protect and repair cellular components, but it is unknown how these interventions might slow the functional decline of extracellular matrices, which are also damaged during ageing. Reduced insulin/IGF-1 signalling (rIIS) extends lifespan across the evolutionary spectrum, and in juvenile Caenorhabditis elegans also allows the transcription factor DAF-16/FOXO to induce development into dauer, a diapause that withstands harsh conditions. It has been suggested that rIIS delays C. elegans ageing through activation of dauer-related processes during adulthood, but some rIIS conditions confer robust lifespan extension unaccompanied by any dauer-like traits. Here we show that rIIS can promote C. elegans longevity through a program that is genetically distinct from the dauer pathway, and requires the Nrf (NF-E2-related factor) orthologue SKN-1 acting in parallel to DAF-16. SKN-1 is inhibited by IIS and has been broadly implicated in longevity, but is rendered dispensable for rIIS lifespan extension by even mild activity of dauer-related processes. When IIS is decreased under conditions that do not induce dauer traits, SKN-1 most prominently increases expression of collagens and other extracellular matrix genes. Diverse genetic, nutritional, and pharmacological pro-longevity interventions delay an age-related decline in collagen expression. These collagens mediate adulthood extracellular matrix remodelling, and are needed for ageing to be delayed by interventions that do not involve dauer traits. By genetically delineating a dauer-independent rIIS ageing pathway, our results show that IIS controls a broad set of protective mechanisms during C. elegans adulthood, and may facilitate elucidation of processes of general importance for longevity. The importance of collagen production in diverse anti-ageing interventions implies that extracellular matrix remodelling is a generally essential signature of longevity assurance, and that agents promoting extracellular matrix youthfulness may have systemic benefit.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352135/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352135/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ewald, Collin Y -- Landis, Jess N -- Porter Abate, Jess -- Murphy, Coleen T -- Blackwell, T Keith -- 5T32DK007260/DK/NIDDK NIH HHS/ -- GM062891/GM/NIGMS NIH HHS/ -- P30 DK036836/DK/NIDDK NIH HHS/ -- P30DK036836/DK/NIDDK NIH HHS/ -- R01 GM062891/GM/NIGMS NIH HHS/ -- England -- Nature. 2015 Mar 5;519(7541):97-101. doi: 10.1038/nature14021. Epub 2014 Dec 15.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉1] Joslin Diabetes Center, One Joslin Place, Boston, Massachusetts 02215, USA [2] Harvard Stem Cell Institute, 7 Divinity Avenue, Cambridge, Massachusetts 02138, USA [3] Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02215, USA. ; Department of Molecular Biology, Lewis-Sigler Institute for Integrative Genomics, Princeton University, 148 Carl Icahn Laboratory, Washington Road, Princeton, New Jersey 08544, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25517099" target="_blank"〉PubMed〈/a〉
    Keywords: Aging/physiology ; Animals ; Caenorhabditis elegans/growth & development/*metabolism ; Caenorhabditis elegans Proteins/*metabolism ; Collagen/biosynthesis/genetics/*metabolism ; DNA-Binding Proteins/*metabolism ; Extracellular Matrix/metabolism ; Forkhead Transcription Factors ; Insulin/*metabolism ; Insulin-Like Growth Factor I/*metabolism ; Larva/growth & development ; Longevity/*physiology ; *Signal Transduction ; Transcription Factors/*metabolism
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 3
    Publication Date: 2014-08-01
    Description: The solar neighbourhood is the closest and most easily studied sample of the Galactic interstellar medium, an understanding of which is essential for models of star formation and galaxy evolution. Observations of an unexpectedly intense diffuse flux of easily absorbed 1/4-kiloelectronvolt X-rays, coupled with the discovery that interstellar space within about a hundred parsecs of the Sun is almost completely devoid of cool absorbing gas, led to a picture of a 'local cavity' filled with X-ray-emitting hot gas, dubbed the local hot bubble. This model was recently challenged by suggestions that the emission could instead be readily produced within the Solar System by heavy solar-wind ions exchanging electrons with neutral H and He in interplanetary space, potentially removing the major piece of evidence for the local existence of million-degree gas within the Galactic disk. Here we report observations showing that the total solar-wind charge-exchange contribution is approximately 40 per cent of the 1/4-keV flux in the Galactic plane. The fact that the measured flux is not dominated by charge exchange supports the notion of a million-degree hot bubble extending about a hundred parsecs from the Sun.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Galeazzi, M -- Chiao, M -- Collier, M R -- Cravens, T -- Koutroumpa, D -- Kuntz, K D -- Lallement, R -- Lepri, S T -- McCammon, D -- Morgan, K -- Porter, F S -- Robertson, I P -- Snowden, S L -- Thomas, N E -- Uprety, Y -- Ursino, E -- Walsh, B M -- England -- Nature. 2014 Aug 14;512(7513):171-3. doi: 10.1038/nature13525. Epub 2014 Jul 27.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physics, University of Miami, Coral Gables, Florida 33124, USA. ; NASA Goddard Space Flight Center, Greenbelt, Maryland 20771, USA. ; Department of Physics and Astronomy, University of Kansas, Lawrence, Kansas 66045, USA. ; Universite Versailles St Quentin; Sorbonne Universites, UPMC Universite Paris 06; CNRS/INSU, LATMOS-IPSL, Guyancourt 78280, France. ; The Henry A. Rowland Department of Physics and Astronomy, Johns Hopkins University, Baltimore, Maryland 21218, USA. ; GEPI Observatoire de Paris, CNRS UMR 8111, Universite Paris Diderot, 92190, Meudon, France. ; Department of Atmospheric, Oceanic and Space Sciences, University of Michigan, Ann Arbor, Michigan 48109, USA. ; Department of Physics, University of Wisconsin, Madison, Wisconsin 53706, USA. ; 1] NASA Goddard Space Flight Center, Greenbelt, Maryland 20771, USA [2] Space Sciences Laboratory, University of California, Berkeley, California 94720, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25079321" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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