Publication Date:
2013-09-14
Description:
Apps et al. (Reports, 5 April 2013, p. 87) found that high human leukocyte antigen C (HLA-C) expression favors HIV-1 control. However, as noted here, HLA-C was assessed with a monoclonal antibody (DT9) that cross-reacts with HLA-E. In the context of the available evidence, this is consistent with the idea that the two leukocyte antigens collaborate to keep the HIV-1 virus at bay.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lo Monaco, Elisa -- Tremante, Elisa -- Biswas, Priscilla -- Cranage, Martin P -- Zipeto, Donato -- Beretta, Alberto -- Giacomini, Patrizio -- New York, N.Y. -- Science. 2013 Sep 13;341(6151):1175. doi: 10.1126/science.1241266.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Istituto Nazionale Tumori Regina Elena, Via delle Messi d'Oro 156, 00158 Roma, Italy.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24031002" target="_blank"〉PubMed〈/a〉
Keywords:
*Gene Expression Regulation
;
HIV/*immunology
;
HIV Infections/*genetics/*immunology
;
HLA-C Antigens/*genetics
;
Humans
;
T-Lymphocytes, Cytotoxic/*immunology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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