Publication Date:
2011-09-16
Description:
Three new neolignans, (7 S ,8 S ,7′ E )-4,9-dihydroxy-3,7,3′,9′-tetramethoxy-8,4′-oxyneolign-7′-ene ( 1 ), (7 R ,8 S ,7′ E )-4, 9-dihydroxy-3,7,3′,9′-tetramethoxy-8,4′-oxyneolign-7′-ene ( 2 ), (7 S ,8 S ,7′ E )-5, 9-dihydroxy-3,7,3′,5′,9′-pentamethoxy-8,4′-oxyneolign-7′-ene ( 3 ), and one new phenylpropanoid, threo -5-hydroxy-3,7-dimethoxyphenylpropane-8,9-diol ( 4 ), were isolated from the leaves and stems of Toona ciliata var. pubescens. Their structures were determined on the basis of spectroscopic analysis, especially 2D-NMR, HR-ESI-MS, and CD data. The antiproliferative activities of these compounds against four tumor cell lines (A549, Colo 205, QGY-7703, and LOVO) were also evaluated by MTT (=(3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2 H -tetrazolium bromide) method.
Print ISSN:
0018-019X
Electronic ISSN:
1522-2675
Topics:
Chemistry and Pharmacology
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