Publication Date:
2008-07-19
Description:
The large majority of antibiotics currently used for treating infections and the antibiotic resistance genes acquired by human pathogens each have an environmental origin. Recent work indicates that the function of these elements in their environmental reservoirs may be very distinct from the "weapon-shield" role they play in clinical settings. Changes in natural ecosystems, including the release of large amounts of antimicrobials, might alter the population dynamics of microorganisms, including selection of resistance, with consequences for human health that are difficult to predict.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Martinez, Jose L -- New York, N.Y. -- Science. 2008 Jul 18;321(5887):365-7. doi: 10.1126/science.1159483.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Departamento de Biotecnologia Microbiana, Centro Nacional de Biotecnologia (CSIC), Darwin 3, Campus UAM, Cantoblanco, 28049-Madrid, and CIBERESP, Spain. jlmtnez@cnb.csic.es〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18635792" target="_blank"〉PubMed〈/a〉
Keywords:
Anti-Bacterial Agents/*metabolism/*pharmacology/therapeutic use
;
Bacteria/*drug effects/genetics/metabolism
;
Bacterial Infections/drug therapy/microbiology
;
Drug Resistance, Bacterial/*genetics
;
Drug Resistance, Multiple, Bacterial/*genetics
;
*Ecosystem
;
Evolution, Molecular
;
Gene Transfer, Horizontal
;
*Genes, Bacterial
;
Humans
;
Mutation
;
Soil Microbiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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