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  • Springer Nature  (26)
  • American Association for the Advancement of Science  (7)
  • American Association for the Advancement of Science (AAAS)  (7)
  • Nature Publishing Group
  • Periodicals Archive Online (PAO)
  • 2005-2009  (40)
  • 1975-1979
  • 1950-1954
  • 2008  (40)
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  • 2005-2009  (40)
  • 1975-1979
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  • 1
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2008-10-18
    Description: Positive and negative feedback loops are common regulatory elements in biological signaling systems. We discuss core feedback motifs that have distinct roles in shaping signaling responses in space and time. We also discuss approaches to experimentally investigate feedback loops in signaling systems.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2680159/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2680159/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brandman, Onn -- Meyer, Tobias -- R01 GM030179/GM/NIGMS NIH HHS/ -- R01 GM030179-25/GM/NIGMS NIH HHS/ -- R01 GM063702/GM/NIGMS NIH HHS/ -- R01 GM063702-06/GM/NIGMS NIH HHS/ -- R01GM030179/GM/NIGMS NIH HHS/ -- R01GM063702/GM/NIGMS NIH HHS/ -- R01MH064801/MH/NIMH NIH HHS/ -- R33 CA120732/CA/NCI NIH HHS/ -- R33 CA120732-02/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 2008 Oct 17;322(5900):390-5. doi: 10.1126/science.1160617.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cellular and Molecular Pharmacology, University of California-San Francisco and Howard Hughes Medical Institute, San Francisco, CA 94158, USA. Onn.Brandman@ucsf.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18927383" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Calcium/metabolism ; *Calcium Signaling ; Cell Membrane/metabolism ; Chemotaxis, Leukocyte ; Computer Simulation ; Endoplasmic Reticulum/metabolism ; *Feedback, Physiological ; Models, Biological ; Neutrophils/*metabolism/physiology ; Phosphatidylinositol 3-Kinases/*metabolism ; *Signal Transduction
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
    Publication Date: 2008-08-02
    Description: Hotspots of high species diversity are a prominent feature of modern global biodiversity patterns. Fossil and molecular evidence is starting to reveal the history of these hotspots. There have been at least three marine biodiversity hotspots during the past 50 million years. They have moved across almost half the globe, with their timing and locations coinciding with major tectonic events. The birth and death of successive hotspots highlights the link between environmental change and biodiversity patterns. The antiquity of the taxa in the modern Indo-Australian Archipelago hotspot emphasizes the role of pre-Pleistocene events in shaping modern diversity patterns.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Renema, W -- Bellwood, D R -- Braga, J C -- Bromfield, K -- Hall, R -- Johnson, K G -- Lunt, P -- Meyer, C P -- McMonagle, L B -- Morley, R J -- O'Dea, A -- Todd, J A -- Wesselingh, F P -- Wilson, M E J -- Pandolfi, J M -- New York, N.Y. -- Science. 2008 Aug 1;321(5889):654-7. doi: 10.1126/science.1155674.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Nationaal Natuurhistorisch Museum, Naturalis, 2300 RA, Leiden, Netherlands. Renema@naturalis.nl〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18669854" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anthozoa/classification ; *Biodiversity ; Climate ; Ecosystem ; Fishes/classification ; *Fossils ; Geological Phenomena ; Geology ; *Marine Biology ; Mollusca/classification ; Phylogeny ; Rhizophoraceae/classification ; *Seawater ; Time
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
    Publication Date: 2008-06-28
    Description: The atmospheric Cherenkov gamma-ray telescope MAGIC, designed for a low-energy threshold, has detected very-high-energy gamma rays from a giant flare of the distant Quasi-Stellar Radio Source (in short: radio quasar) 3C 279, at a distance of more than 5 billion light-years (a redshift of 0.536). No quasar has been observed previously in very-high-energy gamma radiation, and this is also the most distant object detected emitting gamma rays above 50 gigaelectron volts. Because high-energy gamma rays may be stopped by interacting with the diffuse background light in the universe, the observations by MAGIC imply a low amount for such light, consistent with that known from galaxy counts.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉MAGIC Collaboration -- Albert, J -- Aliu, E -- Anderhub, H -- Antonelli, L A -- Antoranz, P -- Backes, M -- Baixeras, C -- Barrio, J A -- Bartko, H -- Bastieri, D -- Becker, J K -- Bednarek, W -- Berger, K -- Bernardini, E -- Bigongiari, C -- Biland, A -- Bock, R K -- Bonnoli, G -- Bordas, P -- Bosch-Ramon, V -- Bretz, T -- Britvitch, I -- Camara, M -- Carmona, E -- Chilingarian, A -- Commichau, S -- Contreras, J L -- Cortina, J -- Costado, M T -- Covino, S -- Curtef, V -- Dazzi, F -- De Angelis, A -- De Cea Del Pozo, E -- de Los Reyes, R -- De Lotto, B -- De Maria, M -- De Sabata, F -- Mendez, C Delgado -- Dominguez, A -- Dorner, D -- Doro, M -- Errando, M -- Fagiolini, M -- Ferenc, D -- Fernandez, E -- Firpo, R -- Fonseca, M V -- Font, L -- Galante, N -- Lopez, R J Garcia -- Garczarczyk, M -- Gaug, M -- Goebel, F -- Hayashida, M -- Herrero, A -- Hohne, D -- Hose, J -- Hsu, C C -- Huber, S -- Jogler, T -- Kneiske, T M -- Kranich, D -- La Barbera, A -- Laille, A -- Leonardo, E -- Lindfors, E -- Lombardi, S -- Longo, F -- Lopez, M -- Lorenz, E -- Majumdar, P -- Maneva, G -- Mankuzhiyil, N -- Mannheim, K -- Maraschi, L -- Mariotti, M -- Martinez, M -- Mazin, D -- Meucci, M -- Meyer, M -- Miranda, J M -- Mirzoyan, R -- Mizobuchi, S -- Moles, M -- Moralejo, A -- Nieto, D -- Nilsson, K -- Ninkovic, J -- Otte, N -- Oya, I -- Panniello, M -- Paoletti, R -- Paredes, J M -- Pasanen, M -- Pascoli, D -- Pauss, F -- Pegna, R G -- Perez-Torres, M A -- Persic, M -- Peruzzo, L -- Piccioli, A -- Prada, F -- Prandini, E -- Puchades, N -- Raymers, A -- Rhode, W -- Ribo, M -- Rico, J -- Rissi, M -- Robert, A -- Rugamer, S -- Saggion, A -- Saito, T Y -- Salvati, M -- Sanchez-Conde, M -- Sartori, P -- Satalecka, K -- Scalzotto, V -- Scapin, V -- Schmitt, R -- Schweizer, T -- Shayduk, M -- Shinozaki, K -- Shore, S N -- Sidro, N -- Sierpowska-Bartosik, A -- Sillanpaa, A -- Sobczynska, D -- Spanier, F -- Stamerra, A -- Stark, L S -- Takalo, L -- Tavecchio, F -- Temnikov, P -- Tescaro, D -- Teshima, M -- Tluczykont, M -- Torres, D F -- Turini, N -- Vankov, H -- Venturini, A -- Vitale, V -- Wagner, R M -- Wittek, W -- Zabalza, V -- Zandanel, F -- Zanin, R -- Zapatero, J -- New York, N.Y. -- Science. 2008 Jun 27;320(5884):1752-4. doi: 10.1126/science.1157087.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Universitat Wurzburg, D-97074 Wurzburg, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18583607" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
    Publication Date: 2008-10-18
    Description: One fundamental question about pulsars concerns the mechanism of their pulsed electromagnetic emission. Measuring the high-end region of a pulsar's spectrum would shed light on this question. By developing a new electronic trigger, we lowered the threshold of the Major Atmospheric gamma-ray Imaging Cherenkov (MAGIC) telescope to 25 giga-electron volts. In this configuration, we detected pulsed gamma-rays from the Crab pulsar that were greater than 25 giga-electron volts, revealing a relatively high cutoff energy in the phase-averaged spectrum. This indicates that the emission occurs far out in the magnetosphere, hence excluding the polar-cap scenario as a possible explanation of our measurement. The high cutoff energy also challenges the slot-gap scenario.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉MAGIC Collaboration -- Aliu, E -- Anderhub, H -- Antonelli, L A -- Antoranz, P -- Backes, M -- Baixeras, C -- Barrio, J A -- Bartko, H -- Bastieri, D -- Becker, J K -- Bednarek, W -- Berger, K -- Bernardini, E -- Bigongiari, C -- Biland, A -- Bock, R K -- Bonnoli, G -- Bordas, P -- Bosch-Ramon, V -- Bretz, T -- Britvitch, I -- Camara, M -- Carmona, E -- Chilingarian, A -- Commichau, S -- Contreras, J L -- Cortina, J -- Costado, M T -- Covino, S -- Curtef, V -- Dazzi, F -- De Angelis, A -- De Cea Del Pozo, E -- de Los Reyes, R -- De Lotto, B -- De Maria, M -- De Sabata, F -- Delgado Mendez, C -- Dominguez, A -- Dorner, D -- Doro, M -- Elsasser, D -- Errando, M -- Fagiolini, M -- Ferenc, D -- Fernandez, E -- Firpo, R -- Fonseca, M V -- Font, L -- Galante, N -- Garcia Lopez, R J -- Garczarczyk, M -- Gaug, M -- Goebel, F -- Hadasch, D -- Hayashida, M -- Herrero, A -- Hohne, D -- Hose, J -- Hsu, C C -- Huber, S -- Jogler, T -- Kranich, D -- La Barbera, A -- Laille, A -- Leonardo, E -- Lindfors, E -- Lombardi, S -- Longo, F -- Lopez, M -- Lorenz, E -- Majumdar, P -- Maneva, G -- Mankuzhiyil, N -- Mannheim, K -- Maraschi, L -- Mariotti, M -- Martinez, M -- Mazin, D -- Meucci, M -- Meyer, M -- Miranda, J M -- Mirzoyan, R -- Moles, M -- Moralejo, A -- Nieto, D -- Nilsson, K -- Ninkovic, J -- Otte, N -- Oya, I -- Paoletti, R -- Paredes, J M -- Pasanen, M -- Pascoli, D -- Pauss, F -- Pegna, R G -- Perez-Torres, M A -- Persic, M -- Peruzzo, L -- Piccioli, A -- Prada, F -- Prandini, E -- Puchades, N -- Raymers, A -- Rhode, W -- Ribo, M -- Rico, J -- Rissi, M -- Robert, A -- Rugamer, S -- Saggion, A -- Saito, T Y -- Salvati, M -- Sanchez-Conde, M -- Sartori, P -- Satalecka, K -- Scalzotto, V -- Scapin, V -- Schweizer, T -- Shayduk, M -- Shinozaki, K -- Shore, S N -- Sidro, N -- Sierpowska-Bartosik, A -- Sillanpaa, A -- Sobczynska, D -- Spanier, F -- Stamerra, A -- Stark, L S -- Takalo, L -- Tavecchio, F -- Temnikov, P -- Tescaro, D -- Teshima, M -- Tluczykont, M -- Torres, D F -- Turini, N -- Vankov, H -- Venturini, A -- Vitale, V -- Wagner, R M -- Wittek, W -- Zabalza, V -- Zandanel, F -- Zanin, R -- Zapatero, J -- de Jager, O C -- de Ona Wilhelmi, E -- New York, N.Y. -- Science. 2008 Nov 21;322(5905):1221-4. doi: 10.1126/science.1164718. Epub 2008 Oct 16.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18927358" target="_blank"〉PubMed〈/a〉
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  • 5
    Publication Date: 2008-07-26
    Description: Biological formation and consumption of molecular hydrogen (H2) are catalyzed by hydrogenases, of which three phylogenetically unrelated types are known: [NiFe]-hydrogenases, [FeFe]-hydrogenases, and [Fe]-hydrogenase. We present a crystal structure of [Fe]-hydrogenase at 1.75 angstrom resolution, showing a mononuclear iron coordinated by the sulfur of cysteine 176, two carbon monoxide (CO) molecules, and the sp2-hybridized nitrogen of a 2-pyridinol compound with back-bonding properties similar to those of cyanide. The three-dimensional arrangement of the ligands is similar to that of thiolate, CO, and cyanide ligated to the low-spin iron in binuclear [NiFe]- and [FeFe]-hydrogenases, although the enzymes have evolved independently and the CO and cyanide ligands are not found in any other metalloenzyme. The related iron ligation pattern of hydrogenases exemplifies convergent evolution and presumably plays an essential role in H2 activation. This finding may stimulate the ongoing synthesis of catalysts that could substitute for platinum in applications such as fuel cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shima, Seigo -- Pilak, Oliver -- Vogt, Sonja -- Schick, Michael -- Stagni, Marco S -- Meyer-Klaucke, Wolfram -- Warkentin, Eberhard -- Thauer, Rudolf K -- Ermler, Ulrich -- New York, N.Y. -- Science. 2008 Jul 25;321(5888):572-5. doi: 10.1126/science.1158978.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Max-Planck-Institut fur Terrestrische Mikrobiologie and Laboratorium fur Mikrobiologie, Fachbereich Biologie, Philipps-Universitat Marburg, Karl-von-Frisch-Strasse, D-35043 Marburg, Germany. shima@mpi-marburg.mpg.de〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18653896" target="_blank"〉PubMed〈/a〉
    Keywords: Apoenzymes/chemistry ; Binding Sites ; Carbon Monoxide/chemistry ; Catalytic Domain ; Coenzymes/chemistry ; Crystallography, X-Ray ; Cyanides/chemistry/metabolism ; Dimerization ; Evolution, Molecular ; Holoenzymes/chemistry ; Hydrogen/chemistry/*metabolism ; Hydrogenase/*chemistry/isolation & purification/metabolism ; Iron/chemistry ; Ligands ; Methane/biosynthesis ; Methanococcales/*enzymology ; Models, Molecular ; Oxidation-Reduction ; Protein Structure, Secondary ; Protein Structure, Tertiary
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2008-08-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Meyer-Lindenberg, Andreas -- New York, N.Y. -- Science. 2008 Aug 8;321(5890):778-80. doi: 10.1126/science.1162908.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Central Institute of Mental Health, J5, University of Heidelberg, 68159 Mannheim, Germany. a.meyerlindenberg@zi-mannheim.de〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18687945" target="_blank"〉PubMed〈/a〉
    Keywords: Borderline Personality Disorder/*physiopathology/*psychology ; Cerebral Cortex/*physiopathology ; *Cooperative Behavior ; *Games, Experimental ; Humans ; Social Behavior ; Trust/*psychology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
    Publication Date: 2008-08-16
    Description: During synaptic vesicle fusion, the soluble N-ethylmaleimide-sensitive factor-attachment protein receptor (SNARE) protein syntaxin-1 exhibits two conformations that both bind to Munc18-1: a "closed" conformation outside the SNARE complex and an "open" conformation in the SNARE complex. Although SNARE complexes containing open syntaxin-1 and Munc18-1 are essential for exocytosis, the function of closed syntaxin-1 is unknown. We generated knockin/knockout mice that expressed only open syntaxin-1B. Syntaxin-1B(Open) mice were viable but succumbed to generalized seizures at 2 to 3 months of age. Binding of Munc18-1 to syntaxin-1 was impaired in syntaxin-1B(Open) synapses, and the size of the readily releasable vesicle pool was decreased; however, the rate of synaptic vesicle fusion was dramatically enhanced. Thus, the closed conformation of syntaxin-1 gates the initiation of the synaptic vesicle fusion reaction, which is then mediated by SNARE-complex/Munc18-1 assemblies.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3235364/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3235364/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gerber, Stefan H -- Rah, Jong-Cheol -- Min, Sang-Won -- Liu, Xinran -- de Wit, Heidi -- Dulubova, Irina -- Meyer, Alexander C -- Rizo, Josep -- Arancillo, Marife -- Hammer, Robert E -- Verhage, Matthijs -- Rosenmund, Christian -- Sudhof, Thomas C -- NS051262/NS/NINDS NIH HHS/ -- NS37200/NS/NINDS NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2008 Sep 12;321(5895):1507-10. doi: 10.1126/science.1163174. Epub 2008 Aug 14.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390-9111, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18703708" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Calcium/metabolism ; Epilepsy/etiology ; Excitatory Postsynaptic Potentials ; Membrane Fusion ; Mice ; Mice, Knockout ; Munc18 Proteins/metabolism ; Mutation ; Protein Conformation ; Protein Structure, Tertiary ; SNARE Proteins/metabolism ; Sucrose/metabolism ; Synapses/physiology ; Synaptic Vesicles/*physiology/ultrastructure ; Syntaxin 1/*chemistry/genetics/*metabolism
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
    Publication Date: 2008-04-13
    Print ISSN: 1548-7091
    Electronic ISSN: 1548-7105
    Topics: Biology , Medicine
    Published by Springer Nature
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  • 9
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