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  • Artikel  (2)
  • 04. Solid Earth::04.07. Tectonophysics::04.07.06. Subduction related processes  (1)
  • *Cell Movement
  • Male
  • 2020-2023
  • 2005-2009  (2)
  • 2007  (2)
  • 1
    Publikationsdatum: 2007-01-06
    Beschreibung: Wilms tumor is a pediatric kidney cancer associated with inactivation of the WT1 tumor-suppressor gene in 5 to 10% of cases. Using a high-resolution screen for DNA copy-number alterations in Wilms tumor, we identified somatic deletions targeting a previously uncharacterized gene on the X chromosome. This gene, which we call WTX, is inactivated in approximately one-third of Wilms tumors (15 of 51 tumors). Tumors with mutations in WTX lack WT1 mutations, and both genes share a restricted temporal and spatial expression pattern in normal renal precursors. In contrast to biallelic inactivation of autosomal tumor-suppressor genes, WTX is inactivated by a monoallelic "single-hit" event targeting the single X chromosome in tumors from males and the active X chromosome in tumors from females.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rivera, Miguel N -- Kim, Woo Jae -- Wells, Julie -- Driscoll, David R -- Brannigan, Brian W -- Han, Moonjoo -- Kim, James C -- Feinberg, Andrew P -- Gerald, William L -- Vargas, Sara O -- Chin, Lynda -- Iafrate, A John -- Bell, Daphne W -- Haber, Daniel A -- P01-CA101942/CA/NCI NIH HHS/ -- R37 CA054358/CA/NCI NIH HHS/ -- R37 CA054358-17/CA/NCI NIH HHS/ -- R37-CA058596/CA/NCI NIH HHS/ -- T32-CA009216/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 2007 Feb 2;315(5812):642-5. Epub 2007 Jan 4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Massachusetts General Hospital Cancer Center, Harvard Medical Center, Boston, MA 02114, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17204608" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adaptor Proteins, Signal Transducing ; Alleles ; Amino Acid Sequence ; Animals ; Cell Line ; Chromosome Deletion ; Chromosomes, Human, X/*genetics ; Female ; Gene Expression ; *Gene Silencing ; *Genes, Wilms Tumor ; Heterozygote ; Humans ; In Situ Hybridization, Fluorescence ; Kidney/embryology/metabolism ; Kidney Neoplasms/*genetics ; Male ; Mice ; Mice, Inbred C57BL ; Molecular Sequence Data ; Mutation ; Point Mutation ; Tumor Suppressor Proteins/chemistry/*genetics/physiology ; Wilms Tumor/*genetics ; beta Catenin/genetics
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 2
    Publikationsdatum: 2017-04-04
    Beschreibung: The West Philippine Basin (WPB) is a back-arc basin that opened within the Philippine Sea Plate (PSP) between the current position of the Palau-Kyushu Ridge (PKR) and the margin of East Asia. Spreading occurred at the Central Basin Fault (CBF) mainly from 54 until 30 Ma. The PKR was active since ~ 48 to 35 Ma constituting a single volcanic arc with the Izu-Bonin-Mariana (IBM) Arc. At ~ 42 Ma ago spreading rate and direction changed from NE-SW to NS, stopping at ~ 30 Ma. A late phase of spreading and volcanism took place between 30 and 26 Ma. ODP Leg 195 Site 1201 is located in the WPB, ~ 100 km west of the PKR, on 49 Ma crust formed by NE-SW spreading at the CBF. From ~ 35 to 30 Ma, pelagic sedimentation at Site 1201 was followed by turbidite sedimentation, fed mostly by arc-derived volcanic clasts. The geochemical and isotopic features of Site 1201 basement rocks, which represent Eocene WPB oceanic crust, compared with those of Site 1201 volcanics from the turbidite sequence, representing products of the early Mariana Arc (PKR), provide some insights into the early history of the IBM subduction factory. The WPB basement is made up of aphyric to porphyritic basalts with altered olivine, and preserved plagioclase, clinopyroxene and opaques. The PKR volcanics are porphyritic basalts and andesites with plagioclase, clino- and orthopyroxene, hornblende, alkali feldspar and opaques. Variable textures, and degree of alteration suggesting zeolite facies metamorphic grade, characterize both groups of rocks. The mineralogical and geochemical characteristics of the investigated Site 1201 PKR volcanics highlight their calc-alkaline affinity. This feature is at variance with both other PKR rocks, having mostly boninitic and arc tholeiitic affinity, and WPB basement basalt, having tholeiitic affinity, with some characters transitional to arc-like, as expected for a back-arc basin. New Sr and Nd isotope data, coupled with published Sr, Nd, Pb and Hf isotope data (Savov et al., 2006), highlight the Indian Ocean MORB-like character of Site 1201 basement basalts. This suggests that WPB volcanism tapped an upper mantle domain distinct from that underlying the Pacific Plate. The isotopic features of Site 1201 PKR volcanics are more enriched relative to those of basement basalts reflecting higher amounts of subduction-derived component(s) in the source of arc magmas. Th-Nb relationships and isotope geochemistry of the WPB basement and overlaying arc volcanics suggest addition of subducted sediment mostly as siliceous melts, to the mantle source of the arc volcanics. In that respect, Site 1201 PKR volcanics resemble calc-alkaline volcanics of the currently active Mariana Arc. In addition, the calc-alkaline affinity, unradiogenic neodymium, and inferred Middle Oligocene age of PKR volcanics, suggest they might represent an evolved stage of arc volcanism at Palau-Kyushu Ridge, perhaps shortly before the end of its activity.
    Beschreibung: Published
    Beschreibung: 157-171
    Beschreibung: JCR Journal
    Beschreibung: open
    Schlagwort(e): Petrogenesis ; mineral chemistry, ; 04. Solid Earth::04.07. Tectonophysics::04.07.06. Subduction related processes ; 04. Solid Earth::04.07. Tectonophysics::04.07.08. Volcanic arcs ; 04. Solid Earth::04.08. Volcanology::04.08.05. Volcanic rocks
    Repository-Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Materialart: article
    Standort Signatur Erwartet Verfügbarkeit
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