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  • Brine shrimp eggs  (1)
  • CYP1C  (1)
  • 2015-2019
  • 2005-2009  (2)
  • 1980-1984
  • 1945-1949
  • 2006  (2)
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Keywords
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  • 2015-2019
  • 2005-2009  (2)
  • 1980-1984
  • 1945-1949
Year
  • 2006  (2)
  • 1
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    An antimalarial cembranolide from Tanzania soft corals, Lobophytum crassum (von Marenzeller (1886) and L. rotundum (Tixier-Durivault (1957). (2006)
    WIOMSA
    Details
    Publication Date: 2021-05-19
    Description: Bioscreening guided fractionation of the extracts of soft corals Lobophytum crassum and L. rotundum using brine shrimp larvae cytotoxicity assay led to the isolation of a cembranolide diterpene (E,E,E)-6,10,14-trimethyl-3-methylene- 3a,4,7,8,11,12,15,15aoctahydrocylotetradeca [b]furan-2(3H)-one (1). This diterpene, identified as cembranolide compound 1, was found to be active against the multidrug-resistant and chloroquine-sensitive strains of Plasmodium falciparum malaria parasite in vitro. It also possessed cytotoxic properties.
    Description: Published
    Keywords: Lobophytum crassum ; L. rotundum ; Plasmodium falciparum ; Antimalarial ; Soft corals ; Cytotoxicity ; Cembranolide ; Parasites ; Parasites ; Coral reefs ; Brine shrimp eggs
    Repository Name: AquaDocs
    Type: Journal Contribution , Refereed , Article
    Format: 58999 bytes
    Format: application/pdf
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  • 2
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    The new vertebrate CYP1C family : cloning of new subfamily members and phylogenetic analysis (2006)
    Details
    Publication Date: 2022-05-26
    Description: Author Posting. © The Authors, 2005. This is the author's version of the work. It is posted here by permission of Elsevier B. V. for personal use, not for redistribution. The definitive version was published in Biochemical and Biophysical Research Communications 331 (2005): 1016-1024, doi:10.1016/j.bbrc.2005.03.231.
    Description: Two novel CYP1 genes from teleost fish constituting a new subfamily have been cloned. These paralogous sequences are designated CYP1C1 and CYP1C2. Both genes were initially obtained from untreated scup Stenotomus chrysops tissues by RT-PCR and RACE. Scup CYP1C1 and CYP1C2 code for 524 and 525 amino acids, respectively, and share 80-81% identity at the nucleotide and amino acid levels. Orthologues of CYP1C1 and CYP1C2 were identified in genome databases for other fish species, and both CYP1B1 and CYP1C1 were cloned from zebrafish (Danio rerio). Phylogenetic analysis shows that CYP1Cs and CYP1Bs constitute a sister clade to the CYP1As. Analysis of sequence domains likely to have functional significance suggests the two CYP1Cs in scup may have catalytic functions and/or substrate specificity that differ from each other and from those of mammalian CYP1Bs or CYP1As. RT-PCR results indicate that CYP1C1 and CYP1C2 are variously expressed in several scup organs.
    Description: This work was supported by EPA grant R 827102-01-0 and NIH grants 5 P42-ES07381 and ES04696. JVG is supported by a Ruth L. Kirschstein NRSA Fellowship (F32 ES012794).
    Keywords: Cytochrome P450 ; CYP1A ; CYP1B1 ; CYP1C ; PAH ; Planar aromatic hydrocarbons
    Repository Name: Woods Hole Open Access Server
    Type: Preprint
    Format: 96256 bytes
    Format: 288797 bytes
    Format: application/msword
    Format: application/pdf
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