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  • 2015-2019
  • 2005-2009  (234)
  • 1960-1964
  • 2005  (234)
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  • 2015-2019
  • 2005-2009  (234)
  • 1960-1964
Year
  • 1
    Monograph available for loan
    Monograph available for loan
    Chichester [u.a.] : Wiley
    Call number: PIK M 370-06-0173
    Type of Medium: Monograph available for loan
    Pages: XIV, 280 S. , Ill, graph. Darst., Kt. , 1 CD-ROM (12 cm)
    Edition: 3. ed
    ISBN: 047085751X , 0-470-85750-1
    Note: Erscheinungsjahr in Vorlageform:2005
    Location: A 18 - must be ordered
    Branch Library: PIK Library
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  • 2
    Electronic Resource
    Electronic Resource
    Bradford : Emerald
    Clinical governance 10 (2005), S. 15-23 
    ISSN: 1477-7274
    Source: Emerald Fulltext Archive Database 1994-2005
    Topics: Medicine , Economics
    Notes: Purpose - To formulate an effective teaching prog ramme in the principles of clinical effectiveness for junior doctors, with simultaneous participation in a clinical audit project during their six-month period of employment. Design/methodology/approach - Accident and Emergency (A&E) Senior House Officers (SHOs) were educated in the principles of clinical effectiveness through a structured five-session approach whilst they concurrently performed their clinical audit project. Throughout the process the A&E SHOs were supported by the Clinical Effectiveness Unit and the A&E Consultant overseeing departmental audit. Findings - The structured teaching programme resulted in a good understanding of the clinical effectiveness process amongst the A&E SHOs, as demonstrated by their ability to perform a clinical audit project which ultimately improved practice. Research limitations/implications - This study has involved the construction and assessment of a teaching framework for junior doctors. The conclusions have been drawn on the basis of objective measures such as the completion of a clinical audit project which successfully improved practice. Thus, the publications of the findings may be considered in the category of a research paper. However, the authors accept that the assessment of a teaching programme's success and its portability to other departments or institutions can be highly subjective. Practical implications - With appropriate guidance and support, junior doctors are able to perform meaningful clinical effectiveness exercises at an early stage in their careers and within the constraints of short periods of employment. The structured teaching approach could be considered as a template which other institutions may wish to adopt to educate their own juniors. Originality/value - Despite the increasing importance of clinical audit in modern practice, the authors are not aware of any published teaching programmes which provide junior doctors with the necessary understanding of and skills required to take part in the clinical effectiveness process.
    Type of Medium: Electronic Resource
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  • 3
  • 4
    Publication Date: 2023-02-24
    Keywords: Acoustic Doppler Current Profiler; ADCP; Current velocity, east-west; Current velocity, north-south; DATE/TIME; DEPTH, water; LATITUDE; LONGITUDE; Shipboard Acoustic Doppler Current Profiling (SADCP); Ship velocity, absolute east-west, standard deviation; Ship velocity, absolute east-west components means; Ship velocity, absolute north-south components mean; Ship velocity, absolute north-south standard deviation; TC9401; TC9401_00139; Temperature, technical; Temperature, technical, standard deviation; Townsend Cromwell; WOCE; World Ocean Circulation Experiment
    Type: Dataset
    Format: text/tab-separated-values, 15672 data points
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  • 5
    Publication Date: 2023-02-24
    Keywords: Acoustic Doppler Current Profiler; ADCP; Current velocity, east-west; Current velocity, north-south; DATE/TIME; DEPTH, water; LATITUDE; LONGITUDE; Shipboard Acoustic Doppler Current Profiling (SADCP); Ship velocity, absolute east-west, standard deviation; Ship velocity, absolute east-west components means; Ship velocity, absolute north-south components mean; Ship velocity, absolute north-south standard deviation; TC9406; TC9406_00141; Temperature, technical; Temperature, technical, standard deviation; Townsend Cromwell; WOCE; World Ocean Circulation Experiment
    Type: Dataset
    Format: text/tab-separated-values, 21734 data points
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  • 6
    Publication Date: 2022-05-25
    Description: Author Posting. © 2005 Author(s). This work is licensed under a Creative Commons License. The definitive version was published Biogeosciences 2 (2005): 141-157, doi:10.5194/bg-2-141-2005.
    Description: Submarine groundwater discharge was quantified by a variety of methods for a 4-day period during the early summer of 2004, in Salt Pond, adjacent to Nauset Marsh, on Cape Cod, USA. Discharge estimates based on radon and salinity took advantage of the presence of the narrow channel connecting Salt Pond to Nauset Marsh, which allowed constructing whole-pond mass balances as water flowed in and out due to tidal fluctuations. The data suggest that less than one quarter of the discharge in the vicinity of Salt Pond happened within the pond itself, while three quarters or more of the discharge occurred immediately seaward of the pond, either in the channel or in adjacent regions of Nauset Marsh. Much of this discharge, which maintains high radon activities and low salinity, is carried into the pond during each incoming tide. A box model was used as an aid to understand both the rates and the locations of discharge in the vicinity of Salt Pond. The model achieves a reasonable fit to both the salinity and radon data assuming submarine groundwater discharge is fresh and that most of it occurs either in the channel or in adjacent regions of Nauset Marsh. Salinity and radon data, together with seepage meter results, do not rule out discharge of saline groundwater, but suggest either that the saline discharge is at most comparable in volume to the fresh discharge or that it is depleted in radon. The estimated rate of fresh groundwater discharge in the vicinity of Salt Pond is 3000-7000 m3 d-1. This groundwater flux estimated from the radon and salinity data is comparable to a value of 3200-4500 m3 d-1 predicted by a recent hydrologic model (Masterson, 2004; Colman and Masterson, 2004), although the model predicts this rate of discharge to the pond whereas our data suggest most of the groundwater bypasses the pond prior to discharge. Additional work is needed to determine if the measured rate of discharge is representative of the long-term average, and to better constrain the rate of groundwater discharge seaward of Salt Pond.
    Description: Financial support was provided by the US Geological Survey and by National Science Foundation grant #OCE-0346933 to MAC.
    Keywords: Submarine groundwater discharge ; Radon
    Repository Name: Woods Hole Open Access Server
    Type: Article
    Format: 5648339 bytes
    Format: application/pdf
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  • 7
    Electronic Resource
    Electronic Resource
    Berkeley, Calif. : Berkeley Electronic Press (now: De Gruyter)
    Statistical applications in genetics and molecular biology 4.2005, 1, art35 
    ISSN: 1544-6115
    Source: Berkeley Electronic Press Academic Journals
    Topics: Biology
    Notes: We describe a method for the generation of knowledge-based potentials and apply it to the observed torsional angles of known protein structures. The potential is derived using Bayesian reasoning, and is useful as a prior for further such reasoning in the presence of additional data. The potential takes the form of a probability density function, which is described by a small number of coefficients with the number of necessary coefficients determined by tests based on statistical significance and entropy. We demonstrate the methods in deriving one such potential corresponding to two dimensions, the Ramachandran plot. In contrast to traditional histogram-based methods, the function is continuous and differentiable. These properties allow us to use the function as a force term in the energy minimization of appropriately described structures. The method can easily be extended to other observable angles and higher dimensions, or to include sequence dependence and should find applications in structure determination and validation.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of the American Water Resources Association 41 (2005), S. 0 
    ISSN: 1752-1688
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Architecture, Civil Engineering, Surveying , Geography
    Notes: Pebble counts have been used for a variety of monitoring projects and are an important component of stream evaluation efforts throughout the United States. The utility of pebble counts as a monitoring tool is, however, based on the monitoring objectives and the assumption that data are collected with sufficient precision to meet those objectives. Depending upon the objective, sources of variability that can limit the precision of pebble count data include substrate heterogeneity at a site, differences in substrate among sample locations within a stream reach, substrate variability among streams, differences in when the substrate sample is collected, differences in how and where technicians pick up substrate particles, and how consistently technicians measure the intermediate axis of a selected particle. This study found that each of these sources of variability is of sufficient magnitude to affect results of monitoring projects. Therefore, actions such as observer training, increasing the number of pebbles measured, evaluating several riffles within a reach, evaluating permanent sites, and narrowing the time window during which pebble counts are conducted should be considered in order to minimize variability. The failure to account for sources of variability associated with pebble counts within the study design may result in failing to meet monitoring objectives.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    Molecular microbiology 58 (2005), S. 0 
    ISSN: 1365-2958
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: In the absence of RecA, expression of the Tus protein of Escherichia coli is lethal when ectopic Ter sites are inserted into the chromosome in an orientation that blocks completion of chromosome replication. Using this observation as a basis for genetic selection, an extragenic suppressor of Tus-mediated arrest of DNA replication was isolated with diminished ability of Tus to halt DNA replication. Resistance to tus expression mapped to a mutation in the stop codon of the topA gene (topA869), generating an elongated topoisomerase I protein with a marked reduction in activity. Other alleles of topA with mutations in the carboxyl-terminal domain of topoisomerase I, topA10 and topA66, also rendered recA strains with blocking Ter sites insensitive to tus expression. Thus, increased negative supercoiling in the DNA of these mutants reduced the ability of Tus–Ter complexes to arrest DNA replication. The increase in superhelical density did not diminish replication arrest by disrupting Tus–Ter interactions, as Tus binding to Ter sites was essentially unaffected by the topA mutations. The topA869 mutation also relieved the requirement for recombination functions other than recA to restart replication, such as recC, ruvA and ruvC, indicating that the primary effect of the increased negative supercoiling was to interfere with Tus blockage of DNA replication. Introduction of gyrB mutations in combination with the topA869 mutation restored supercoiling density to normal values and also restored replication arrest at Ter sites, suggesting that supercoiling alone modulated Tus activity. We propose that increased negative supercoiling enhances DnaB unwinding activity, thereby reducing the duration of the Tus–DnaB interaction and leading to decreased Tus activity.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    350 Main Street , Malden , MA 02148 , USA , and 9600 Garsington Road , Oxford OX4 2DQ , UK . : Blackwell Publishing, Inc.
    Mathematical finance 15 (2005), S. 0 
    ISSN: 1467-9965
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Mathematics , Economics
    Notes: This paper gives an ordering on option prices under various well-known martingale measures in an incomplete stochastic volatility model. Our central result is a comparison theorem that proves convex option prices are decreasing in the market price of volatility risk, the parameter governing the choice of pricing measure. The theorem is applied to order option prices under q-optimal pricing measures. In doing so, we correct orderings demonstrated numerically in Heath, Platen, and Schweizer (Mathematical Finance, 11(4), 2001) in the special case of the Heston model.
    Type of Medium: Electronic Resource
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