ALBERT

Description: High-protein and acidogenic diets induce hypercalciuria. Foods or supplements with excess sulfur-containing amino acids increase endogenous sulfuric acid production and therefore have the potential to increase calcium excretion and alter bone metabolism. In this study, effects of an amino acid/carbohydrate supplement on bone resorption were examined during bed rest. Thirteen subjects were divided at random into two groups: a control group (Con, n = 6) and an amino acid-supplemented group (AA, n = 7) who consumed an extra 49.5 g essential amino acids and 90 g carbohydrate per day for 28 days. Urine was collected for n-telopeptide (NTX), deoxypyridinoline (DPD), calcium, and pH determinations. Bone mineral content was determined and potential renal acid load was calculated. Bone-specific alkaline phosphatase was measured in serum samples collected on day 1 (immediately before bed rest) and on day 28. Potential renal acid load was higher in the AA group than in the Con group during bed rest (P 〈 0.05). For all subjects, during bed rest urinary NTX and DPD concentrations were greater than pre-bed rest levels (P 〈 0.05). Urinary NTX and DPD tended to be higher in the AA group (P = 0.073 and P = 0.056, respectively). During bed rest, urinary calcium was greater than baseline levels (P 〈 0.05) in the AA group but not the Con group. Total bone mineral content was lower after bed rest than before bed rest in the AA group but not the Con group (P 〈 0.05). During bed rest, urinary pH decreased (P 〈 0.05), and it was lower in the AA group than the Con group. These data suggest that bone resorption increased, without changes in bone formation, in the AA group.

Description: No abstract available

Description: Medical requirements for the future Crew Exploration Vehicle (CEV), Lunar Surface Access Module (LSAM), advanced Extravehicular Activity (EVA) suits and Lunar habitat are currently being developed. Crews returning to the lunar surface will construct the lunar habitat and conduct scientific research. Inherent in aggressive surface activities is the potential risk of injury to crewmembers. Physiological responses and the operational environment for short forays during the Apollo lunar missions were studied and documented. Little is known about the operational environment in which crews will live and work and the hardware will be used for long-duration lunar surface operations. Additional information is needed regarding productivity and the events that affect crew function such as a compressed timeline. The Space Medicine Division at the NASA Johnson Space Center (JSC) requested a study in December 2005 to identify Apollo mission issues relevant to medical operations that had impact to crew health and/or performance. The operationally oriented goals of this project were to develop or modify medical requirements for new exploration vehicles and habitats, create a centralized database for future access, and share relevant Apollo information with the multiple entities at NASA and abroad participating in the exploration effort.

Description: To accurately model radiative fluxes at the surface and within the atmosphere, we need to know both vertical and horizontal structures of cloudiness. While MODIS provides accurate information on cloud horizontal structure, it has limited ability to estimate cloud vertical structure. ICESat/GLAS on the other hand, provides the vertical distribution and internal structure of clouds as deep as the laser beam can penetrate and return a signal. Having different orbits, MODIS and GLAS provide few collocated measurements; hence a statistical approach is needed to learn about 3D cloud structures from the two instruments. In the presentation, we show the results of the statistical analysis of vertical and horizontal structure of cloudiness using GLAS and MODIS cloud top(s) data acquired in October-November 2003. We revisit the (H1, C1) plot, previously used for analyzing cloud liquid water data, and illustrate cloud structure for single and multiple-layer clouds.

Description: Lightning is responsible for an estimated 15 percent of total NO emissions, and is one of the most prominent sources in the upper troposphere. In this study, we present evidence of lightning-generated NO2 (LNO2) using data from the Ozone Monitoring Instrument (OMI), which has observed tropospheric NO2 since its launch in 2004. Although LNO2 has been also reported in previous satellite studies from the Global Ozone Monitoring Experiment (GOME) and SCIAMACHY, OMI is better suited for such measurements by virtue of its higher spatial resolution and daily global coverage. We will present data clearly showing the LNO2 signal in the OMI tropospheric NO2 product on two days over and downwind of specific convective systems in the US Midwest. Gridded monthly mean tropospheric NO 2 data are subtracted from the daily gridded data to obtain the presumed LNO2 signal. Observed cloud-to-ground (CG) lightning flashes from the National Lightning Detection Network (NLDN) were counted along middle and upper tropospheric back trajectories that were run from the regions containing the LNO2 signal. A vertically-weighted average number of upwind CG flashes was obtained using a profile of LNO(x) mass obtained from a series of midlatitude cloud-resolved storm chemistry simulations. The number of CG flashes was scaled up to total flashes (intracloud (IC) flashes plus CG) using a climatological IC/CG ratio. The number of moles of LNO(x) in the region considered was estimated by assuming that LNO2 is 30 percent of LNO(x). This value was divided by the number of upwind flashes to obtain an average estimate of the number of moles produced per flash. Results yield values in the range obtained through other estimation techniques (e.g., aircraft measurements, models). We will also present a similar analysis over northern Australia during the SCOUT-O3/ACTIVE field campaigns in November and December 2005, in which we will compare the OMI LNOx signals with aircraft observations from the storm anvils.

Description: Dr. Davis' presentation includes a brief overview of space flight and the lessons learned for health care in microgravity. He will describe the development of policy for health care for international crews. He will conclude his remarks with a discussion of an integrated health care system.

Description: Defining optimal nutrient requirements is imperative to ensure crew health on long-duration space exploration missions. To date, nutrient requirement data have been extremely limited because of small sample sizes and difficulties associated with collecting biological samples. In this study, we examined changes in body composition, bone metabolism, hematology, general blood chemistry, and blood levels of selected vitamins and minerals after long-duration (128-195 d) space flight aboard the International Space Station. Crew members consumed an average of 80% of the recommended energy intakes, and on landing day their body weight had decreased (P=0.051). After flight, hematocrit was less, and serum femtin was greater than before flight (P〈0.01). Serum iron, ferritin saturation, and transferrin had decreased after flight. The finding that other acute-phase proteins, including ceruloplasmin, retinol binding protein, transthyretin, and albumin were not changed after flight suggests that the changes in iron metabolism may not be strictly due to an inflammatory response. Urinary 8- hydroxy-2'-deoxyguanosine concentration was greater and superoxide dismutase was less after flight, indicating that oxidative damage had increased (P〈0.05). Despite the reported use of vitamin D supplements during flight, serum 25-hydroxyvitamin D was significantly decreased after flight (P〈0.01). Bone resorption was increased after flight, as indicated by several urinary markers of bone resorption. Bone formation, assessed by serum concentration of bone-specific alkaline phosphatase, was elevated only in crew members who landed in Russia, probably because of the longer time lapse between landing and sample collection. These data provide evidence that bone loss, compromised vitamin D status, and oxidative damage remain critical concerns for long-duration space flight.

Description: Bone loss is a current limitation for long-term space exploration. Bone markers, calcitropic hormones, and calcium kinetics of crew members on space missions of 4-6 months were evaluated. Spaceflight-induced bone loss was associated with increased bone resorption and decreased calcium absorption. INTRODUCTION: Bone loss is a significant concern for the health of astronauts on long-duration missions. Defining the time course and mechanism of these changes will aid in developing means to counteract these losses during space flight and will have relevance for other clinical situations that impair weight-bearing activity. MATERIALS AND METHODS: We report here results from two studies conducted during the Shuttle-Mir Science Program. Study 1 was an evaluation of bone and calcium biochemical markers of 13 subjects before and after long-duration (4-6 months) space missions. In study 2, stable calcium isotopes were used to evaluate calcium metabolism in six subjects before, during, and after flight. Relationships between measures of bone turnover, biochemical markers, and calcium kinetics were examined. RESULTS: Pre- and postflight study results confirmed that, after landing, bone resorption was increased, as indicated by increases in urinary calcium (p 〈 0.05) and collagen cross-links (N-telopeptide, pyridinoline, and deoxypyridinoline were all increased 〉55% above preflight levels, p 〈 0.001). Parathyroid hormone and vitamin D metabolites were unchanged at landing. Biochemical markers of bone formation were unchanged at landing, but 2-3 weeks later, both bone-specific alkaline phosphatase and osteocalcin were significantly (p 〈 0.01) increased above preflight levels. In studies conducted during flight, bone resorption markers were also significantly higher than before flight. The calcium kinetic data also validated that bone resorption was increased during flight compared with preflight values (668 +/- 130 versus 427 +/- 153 mg/day; p 〈 0.001) and clearly documented that true intestinal calcium absorption was significantly lower during flight compared with preflight values (233 +/- 87 versus 460 +/- 47 mg/day; p 〈 0.01). Weightlessness had a detrimental effect on the balance in bone turnover such that the daily difference in calcium retention during flight compared with preflight values approached 300 mg/day (-234 +/- 102 versus 63 +/- 75 mg/day; p 〈 0.01). CONCLUSIONS: These bone marker and calcium kinetic studies indicated that the bone loss that occurs during space flight is a consequence of increased bone resorption and decreased intestinal calcium absorption.

Description: We combine satellite gravity data from the Gravity Recovery and Climate Experiment (GRACE) and precipitation measurements from the National Oceanic and Atmospheric Administration (NOAA) Climate Prediction Center's (CPC) Merged Analysis of Precipitation (CMAP) and the Tropical Rainfall Measuring Mission (TRMM), over the period from mid-2002 to mid-2006, to investigate the relative importance of sink (runoff and evaporation) and source (precipitation) terms in the hydrological balance of the Amazon Basin. When linear and quadratic terms are removed, the time series of land water storage variations estimated from GRACE exhibits a dominant annual signal of 250 mm peak-to-peak, which is equivalent to a water volume change of approximately 1800 cubic kilometers. A comparison of this trend with accumulated (i.e., integrated) precipitation shows excellent agreement and no evidence of basin saturation. The agreement indicates that the net runoff and evaporation contributes significantly less than precipitation to the annual hydrological mass balance. Indeed, raw residuals between the detrended water storage and precipitation anomalies range from plus or minus 40 mm. This range is consistent with streamflow measurements from the region, although the latter are characterized by a stronger annual signal than ow residuals, suggesting that runoff and evaporation may act to partially cancel each other.

Description: The free-air gravity trend over Canada, derived from the Gravity Recovery and Climate Experiment (GRACE) satellite mission, robustly isolates the gravity signal associated with glacial isostatic adjustment (GIA) from the longer-time scale mantle convection process. This trend proves that the ancient Laurentian ice complex was composed of two large domes to the west and east of Hudson Bay, in accord with one of two classes of earlier reconstructions. Moreover, GIA models that reconcile the peak rates contribute approximately 25 to approximately 45% to the observed static gravity field, which represents an important boundary condition on the buoyancy of the continental tectosphere.