Publication Date:
2004-10-02
Description:
Deinococcus radiodurans is extremely resistant to ionizing radiation. How this bacterium can grow under chronic gamma radiation [50 grays (Gy) per hour] or recover from acute doses greater than 10 kGy is unknown. We show that D. radiodurans accumulates very high intracellular manganese and low iron levels compared with radiation-sensitive bacteria and that resistance exhibits a concentration-dependent response to manganous chloride [Mn(II)]. Among the most radiation-resistant bacterial groups reported, Deinococcus, Enterococcus, Lactobacillus, and cyanobacteria accumulate Mn(II). In contrast, Shewanella oneidensis and Pseudomonas putida have high iron but low intracellular manganese concentrations and are very sensitive. We propose that Mn(II) accumulation facilitates recovery from radiation injury.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Daly, M J -- Gaidamakova, E K -- Matrosova, V Y -- Vasilenko, A -- Zhai, M -- Venkateswaran, A -- Hess, M -- Omelchenko, M V -- Kostandarithes, H M -- Makarova, K S -- Wackett, L P -- Fredrickson, J K -- Ghosal, D -- New York, N.Y. -- Science. 2004 Nov 5;306(5698):1025-8. Epub 2004 Sep 30.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA. mdaly@usuhs.mil〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15459345" target="_blank"〉PubMed〈/a〉
Keywords:
Culture Media
;
DNA Repair
;
DNA, Bacterial
;
Deinococcus/physiology/*radiation effects/ultrastructure
;
Iron/physiology
;
Manganese/*physiology
;
Radiation Tolerance/*physiology
;
Reactive Oxygen Species/metabolism
;
Superoxide Dismutase/metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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