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  • Male  (4)
  • 2005-2009
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  • 1940-1944
  • 2002  (4)
  • 1
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    Covariation of synaptonemal complex length and mammalian meiotic exchange rates (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-06-08
    Description: Analysis of recombination between loci (linkage analysis) has been a cornerstone of human genetic research, enabling investigators to localize and, ultimately, identify genetic loci. However, despite these efforts little is known about patterns of meiotic exchange in human germ cells or the mechanisms that control these patterns. Using recently developed immunofluorescence methodology to examine exchanges in human spermatocytes, we have identified remarkable variation in the rate of recombination within and among individuals. Subsequent analyses indicate that, in humans and mice, this variation is linked to differences in the length of the synaptonemal complex. Thus, at least in mammals, a physical structure, the synaptonemal complex, reflects genetic rather than physical distance.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lynn, Audrey -- Koehler, Kara E -- Judis, LuAnn -- Chan, Ernest R -- Cherry, Jonathan P -- Schwartz, Stuart -- Seftel, Allen -- Hunt, Patricia A -- Hassold, Terry J -- HD07518/HD/NICHD NIH HHS/ -- HD21341/HD/NICHD NIH HHS/ -- HD37502/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 2002 Jun 21;296(5576):2222-5. Epub 2002 Jun 6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Genetics, Case Western Reserve University, Cleveland, OH, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12052900" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptor Proteins, Signal Transducing ; Adult ; Aged ; Animals ; Carrier Proteins ; Chromosomes, Human/physiology/*ultrastructure ; Crossing Over, Genetic ; Female ; Humans ; In Situ Hybridization, Fluorescence ; Male ; *Meiosis ; Mice ; Mice, Inbred Strains ; Microscopy, Fluorescence ; Middle Aged ; Neoplasm Proteins/analysis ; Nuclear Proteins ; *Recombination, Genetic ; Spermatocytes/physiology/*ultrastructure ; Synaptonemal Complex/*ultrastructure
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Sex matters in meiosis (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-06-22
    Description: In mammals, fertilization typically involves the ovulation of one or a few eggs at one end of the female reproductive tract and the entry of millions of sperm at the other. Given this disparity in numbers, it might be expected that the more precious commodity-eggs-would be subject to more stringent quality-control mechanisms. However, information from engineered mutations of meiotic genes suggests just the opposite. Specifically, the available mutants demonstrate striking sexual dimorphism in response to meiotic disruption; for example, faced with adversity, male meiosis grinds to a halt, whereas female meiosis soldiers on. This female "robustness" comes with a cost, however, because aneuploidy appears to be increased in the resultant oocytes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hunt, Patricia A -- Hassold, Terry J -- HD21341/HD/NICHD NIH HHS/ -- HD31866/HD/NICHD NIH HHS/ -- HD37502/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 2002 Jun 21;296(5576):2181-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Genetics, Case Western Reserve University, Cleveland, OH 44106-4955, USA. pah13@po.cwru.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12077403" target="_blank"〉PubMed〈/a〉
    Keywords: Aneuploidy ; Animals ; Cell Cycle ; Female ; Humans ; Male ; *Meiosis ; Mice ; Mutation ; Oocytes/*physiology ; *Oogenesis ; Prophase ; Proteins/genetics/metabolism ; Sex Characteristics ; Spermatocytes/*physiology ; *Spermatogenesis
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Role of melanopsin in circadian responses to light (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-12-14
    Description: Melanopsin has been proposed as an important photoreceptive molecule for the mammalian circadian system. Its importance in this role was tested in melanopsin knockout mice. These mice entrained to a light/dark cycle, phase-shifted after a light pulse, and increased circadian period when light intensity increased. Induction of the immediate-early gene c-fos was observed after a nighttime light pulse in both wild-type and knockout mice. However, the magnitude of these behavioral responses in knockout mice was 40% lower than in wild-type mice. Although melanopsin is not essential for the circadian clock to receive photic input, it contributes significantly to the magnitude of photic responses.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ruby, Norman F -- Brennan, Thomas J -- Xie, Xinmin -- Cao, Vinh -- Franken, Paul -- Heller, H Craig -- O'Hara, Bruce F -- DA13349/DA/NIDA NIH HHS/ -- HL64148/HL/NHLBI NIH HHS/ -- MH60385/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 2002 Dec 13;298(5601):2211-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA. ruby@stanford.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12481140" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Clocks/physiology ; Circadian Rhythm/*physiology ; Darkness ; Female ; Gene Expression Regulation ; Gene Targeting ; Genes, fos ; In Situ Hybridization ; *Light ; Light Signal Transduction ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Motor Activity ; Retinal Ganglion Cells/physiology ; Rod Opsins/genetics/*physiology ; Suprachiasmatic Nucleus/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Extracting 3D from motion: differences in human and monkey intraparietal cortex (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-10-12
    Description: We compared three-dimensional structure-from-motion (3D-SFM) processing in awake monkeys and humans using functional magnetic resonance imaging. Occipital and midlevel extrastriate visual areas showed similar activation by 3D-SFM stimuli in both species. In contrast, intraparietal areas showed significant 3D-SFM activation in humans but not in monkeys. This suggests that human intraparietal cortex contains visuospatial processing areas that are not present in monkeys.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vanduffel, W -- Fize, D -- Peuskens, H -- Denys, K -- Sunaert, S -- Todd, J T -- Orban, G A -- New York, N.Y. -- Science. 2002 Oct 11;298(5592):413-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratorium voor Neuro- en Psychofysiologie, Katholieke Universiteit Leuven, Campus Gasthuisberg, Herestraat 49, Leuven B-3000, Belgium. wim@nmr.mgh.harvard.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12376701" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Attention ; Brain/physiology ; Brain Mapping ; Cues ; Depth Perception/*physiology ; Humans ; Macaca mulatta ; Magnetic Resonance Imaging ; Male ; Motion Perception/*physiology ; Parietal Lobe/*physiology ; Photic Stimulation ; Species Specificity ; Temporal Lobe/physiology ; Visual Cortex/physiology ; Visual Pathways/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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