Publication Date:
2001-06-09
Description:
The mushroom bodies of the Drosophila brain are important for olfactory learning and memory. To investigate the requirement for mushroom body signaling during the different phases of memory processing, we transiently inactivated neurotransmission through this region of the brain by expressing a temperature-sensitive allele of the shibire dynamin guanosine triphosphatase, which is required for synaptic transmission. Inactivation of mushroom body signaling through alpha/beta neurons during different phases of memory processing revealed a requirement for mushroom body signaling during memory retrieval, but not during acquisition or consolidation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McGuire, S E -- Le, P T -- Davis, R L -- NS19904/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2001 Aug 17;293(5533):1330-3. Epub 2001 Jun 7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11397912" target="_blank"〉PubMed〈/a〉
Keywords:
Afferent Pathways/physiology
;
Animals
;
Brain/physiology
;
Conditioning, Classical
;
Drosophila/genetics/*physiology
;
*Drosophila Proteins
;
Dynamins
;
Electroshock
;
GTP Phosphohydrolases/genetics/physiology
;
Gene Targeting
;
Genes, Insect
;
Memory/*physiology
;
Mental Recall/physiology
;
Mutation
;
Neurons/*physiology
;
*Odors
;
Signal Transduction
;
*Synaptic Transmission
;
Temperature
;
Transgenes
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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