Publication Date:
2000-02-26
Description:
Most types of antibiotic resistance impose a biological cost on bacterial fitness. These costs can be compensated, usually without loss of resistance, by second-site mutations during the evolution of the resistant bacteria in an experimental host or in a laboratory medium. Different fitness-compensating mutations were selected depending on whether the bacteria evolved through serial passage in mice or in a laboratory medium. This difference in mutation spectra was caused by either a growth condition-specific formation or selection of the compensated mutants. These results suggest that bacterial evolution to reduce the costs of antibiotic resistance can take different trajectories within and outside a host.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bjorkman, J -- Nagaev, I -- Berg, O G -- Hughes, D -- Andersson, D I -- New York, N.Y. -- Science. 2000 Feb 25;287(5457):1479-82.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Bacteriology, Swedish Institute for Infectious Disease Control, S-171 82 Solna, Sweden.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10688795" target="_blank"〉PubMed〈/a〉
Keywords:
Adaptation, Physiological
;
Animals
;
Anti-Bacterial Agents/*pharmacology
;
*Antiporters
;
Carrier Proteins/genetics
;
Culture Media
;
Drug Resistance, Microbial/*genetics
;
Escherichia coli Proteins
;
Evolution, Molecular
;
Female
;
Fusidic Acid/pharmacology
;
Membrane Proteins/genetics
;
Mice
;
Mice, Inbred BALB C
;
*Mutation
;
Peptide Elongation Factor G/genetics
;
Ribosomal Proteins/genetics
;
Salmonella typhimurium/*drug effects/*genetics/growth & development/metabolism
;
Selection, Genetic
;
Serial Passage
;
Streptomycin/pharmacology
;
Suppression, Genetic
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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