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  • 1
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    Effects of environment on compensatory mutations to ameliorate costs of antibiotic resistance (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2000-02-26
    Description: Most types of antibiotic resistance impose a biological cost on bacterial fitness. These costs can be compensated, usually without loss of resistance, by second-site mutations during the evolution of the resistant bacteria in an experimental host or in a laboratory medium. Different fitness-compensating mutations were selected depending on whether the bacteria evolved through serial passage in mice or in a laboratory medium. This difference in mutation spectra was caused by either a growth condition-specific formation or selection of the compensated mutants. These results suggest that bacterial evolution to reduce the costs of antibiotic resistance can take different trajectories within and outside a host.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bjorkman, J -- Nagaev, I -- Berg, O G -- Hughes, D -- Andersson, D I -- New York, N.Y. -- Science. 2000 Feb 25;287(5457):1479-82.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Bacteriology, Swedish Institute for Infectious Disease Control, S-171 82 Solna, Sweden.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10688795" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptation, Physiological ; Animals ; Anti-Bacterial Agents/*pharmacology ; *Antiporters ; Carrier Proteins/genetics ; Culture Media ; Drug Resistance, Microbial/*genetics ; Escherichia coli Proteins ; Evolution, Molecular ; Female ; Fusidic Acid/pharmacology ; Membrane Proteins/genetics ; Mice ; Mice, Inbred BALB C ; *Mutation ; Peptide Elongation Factor G/genetics ; Ribosomal Proteins/genetics ; Salmonella typhimurium/*drug effects/*genetics/growth & development/metabolism ; Selection, Genetic ; Serial Passage ; Streptomycin/pharmacology ; Suppression, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Sunyaev-Zel'dovich Effect Derived Distance to the High Redshift Clusters MS 0451.6-0305 and CL 0016+16 (2000)
    In:  Other Sources
    Details
    Publication Date: 2019-07-17
    Description: We determine the distances to the z approximately equal to 0.55 galaxy clusters MS 0451.6-0305 and CL 0016+16 from a maximum likelihood joint fit to interferometric Sunyaev-Zel'dovich effect (SZE) and X-ray observations. We model the intracluster medium (ICM) using a spherical isothermal beta-model. We quantify the statistical and systematic uncertainties inherent to these direct distance measurements, and we determine constraints on the Hubble parameter for three different cosmologies. For an OmegaM = 0.3, OmegaL = 0.7 cosmology, these distances imply a Hubble constant of 63(exp 12)(sub -9)(exp +21)(sub -21) km/s/Mpc, where the uncertainties correspond to statistical followed by systematic at 68% confidence. The best fit H(sub o) is 57 km/sec/Mpc for an open OmegaM = 0.3 universe and 52 km/s/Mpc for a flat Omega = 1 universe.
    Keywords: Astronomy
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  • 3
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    Imaging the Sunyaev-Zeldovich Effect in the High Redshift Galaxy Cluster MS1137+66 (2000)
    In:  Other Sources
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    Publication Date: 2019-07-17
    Description: We present interferometric measurements of the Sunyaev-Zelldovich Effect (SZE) in MS1137+66, a distant galaxy cluster at a redshift of 0.78. The data were obtained in 1997 and 1998 at the Berkeley-Illinois-Maryland millimeter array using sensitive 28.5 GHz receivers optimized for imaging of the SZE, with a total on-source integration time of 87.8 hours. We discuss constraints derived from spherical "beta" model fits to the SZE data, place an upper limit on the strength of any possible radio point sources in the field, and compare the results with the x-ray data published by Donahue et al. in 1999.
    Keywords: Astronomy
    Type: Jan 01, 2000; Atlanta, GA; United States
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  • 4
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    The Distance and Mass of the Galaxy Cluster Abell 1995 Derived From Sunyaev-Zel'dovich Effect and X-Ray Measurements (2000)
    In:  Other Sources
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    Publication Date: 2019-07-17
    Description: We present multi-wavelength observations of the Abell 1995 galaxy cluster. From analysis of x-ray spectroscopy and imaging data we derive the electron temperature, cluster core radius, and central electron number density. Using optical spectroscopy of 15 cluster members, we derive an accurate cluster redshift and velocity dispersion. Finally, the interferometric imaging of the SZE toward Abell 1995 at 28.5 GHz provides a measure of the integrated pressure through the cluster.
    Keywords: Astronomy
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