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Structure of Neuritogenic Active Ganglioside from the Sea Cucumber Stichopus japonicus (1999)

Kaneko, Masafumi ; Kisa, Fumiaki ; Yamada, Koji ; [et al.]

Weinheim : Wiley-Blackwell

Liebigs Annalen 1999 (1999), S. 3171-3174

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ISSN: 1434-193X

Keywords: Glycosphingolipid ; Ganglioside ; Sea cucumber ; Stichopus japonicus ; Neuritogenic activity ; Natural products ; Chemistry ; General Chemistry

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology

Notes: A ganglioside molecular species SJG-1 has been obtained from the n-hexane soluble lipid fraction of the chloroform/methanol extract of the sea cucumber Stichopus japonicus. On the basis of chemical and spectroscopic evidence, the structure of SJG-1 has been determined. SJG-1 possesses an N-glycolylneuraminic acid (sialic acid), nonhydroxy fatty acids and phytosphingosine-type long-chain bases as major ceramide components. The ganglioside SJG-1 exhibits neuritogenic activity toward the rat pheochromocytoma cell line PC12 cells in the presence of NGF.

Additional Material: 1 Tab.

Type of Medium: Electronic Resource

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