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  • Aircraft Design, Testing and Performance  (1)
  • Keywords: nitro-PAHs; metabolism; Cunninghamella elegans; biotransformation  (1)
  • S. mansoni  (1)
  • 2020-2022
  • 1995-1999  (3)
  • 1999  (3)
Collection
Keywords
Publisher
Years
  • 2020-2022
  • 1995-1999  (3)
Year
  • 1
    Electronic Resource
    Electronic Resource
    Biotransformation of 1-nitrobenzo[e]pyrene by the fungus Cunninghamella elegans (1999)
    Springer
    Journal of industrial microbiology and biotechnology 22 (1999), S. 52-57 
    Details
    ISSN: 1476-5535
    Keywords: Keywords: nitro-PAHs; metabolism; Cunninghamella elegans; biotransformation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Biotransformation of 1-nitrobenzo[e]pyrene (1-nitro-BeP), an environmental pollutant derived from the nitration of a non-carcinogen, benzo[e]pyrene, was studied using the fungus Cunninghamella elegans ATCC 36112. After 72 h incubation, 89% of 1-nitro-[3H]BeP added had been metabolized to two major metabolites. These metabolites were separated by reversed-phase high performance liquid chromatography and identified by 1H NMR, UV-visible, and mass spectral techniques as 1-nitro-6-benzo[e]pyrenylsulfate and 1-nitrobenzo[e]pyrene 6-O-β-glucopyranoside. Comparison of the fungal metabolism patterns of 1-nitro-BeP and BeP indicates that the nitro group at the C-1 position of BeP altered the regioselectivity of metabolism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/sj.jim.2900601
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Molecular characterisation of a NADH ubiquinone oxidoreductase subunit 5 from Schistosoma mansoni and inhibition of mitochondrial respiratory chain function by testosterone (1999)
    Springer
    Molecular and cellular biochemistry 202 (1999), S. 149-158 
    Details
    ISSN: 1573-4919
    Keywords: NADH Q oxidoreductase ; S. mansoni ; testosterone ; mitochondria
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract Complementary DNA, encoding the mitochondrial enzyme NADH-ubiquinone oxidoreductase subunit 5 (SmND5) of the human parasite Schistosoma mansoni was isolated by screening an S. mansoni cDNA library with a human androgen receptor (hAR) cDNA probe. The complete nucleotide and deduced aminoacid sequences of SmND5 were determined. Southern blot analysis revealed the occurrence of a single copy gene for SmND5 and by means of RT-PCR, it was shown that sex- and stage-specific expression of SmND5 occurred. In order to establish a functional relationship between the mitochondrial enzyme and the androgen receptor, the effects of testosterone were compared to those of classical respiratory chain inhibitors, using adult schistosome and beef heart submitochondrial particles. Physiological concentrations of testosterone were able to inhibit the maintenance of proton gradient across the mitochondrial membranes, as well as ATP synthesis. The steroid was found to be cytotoxic to the larvae, but not to adult schistosomes. A model is proposed to explain the observed in vivo testosterone-related differences in worm burdens, in experimental chronic infections.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1007057903390
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    Paper (German National Licenses)
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  • 3
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    Unknown
    Multidisciplinary Design and Analysis for Commercial Aircraft (1999)
    In:  CASI
    Details
    Publication Date: 2019-08-17
    Description: Multidisciplinary design and analysis (MDA) has become the normal mode of operation within most aerospace companies, but the impact of these changes have largely not been reflected at many universities. On an effort to determine if the emergence of multidisciplinary design concepts should influence engineering curricula, NASA has asked several universities (Virginia Tech, Georgia Tech, Clemson, BYU, and Cal Poly) to investigate the practicality of introducing MDA concepts within their undergraduate curricula. A multidisciplinary team of faculty, students, and industry partners evaluated the aeronautical engineering curriculum at Cal Poly. A variety of ways were found to introduce MDA themes into the curriculum without adding courses or units to the existing program. Both analytic and educational tools for multidisciplinary design of aircraft have been developed and implemented.
    Keywords: Aircraft Design, Testing and Performance
    Format: application/pdf
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    NASA TECHNICAL REPORTS
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