Publication Date:
1997-10-06
Description:
Expression of Agouti protein is normally limited to the skin where it affects pigmentation, but ubiquitous expression causes obesity. An expressed sequence tag was identified that encodes Agouti-related protein, whose RNA is normally expressed in the hypothalamus and whose levels were increased eightfold in ob/ob mice. Recombinant Agouti-related protein was a potent, selective antagonist of Mc3r and Mc4r, melanocortin receptor subtypes implicated in weight regulation. Ubiquitous expression of human AGRP complementary DNA in transgenic mice caused obesity without altering pigmentation. Thus, Agouti-related protein is a neuropeptide implicated in the normal control of body weight downstream of leptin signaling.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ollmann, M M -- Wilson, B D -- Yang, Y K -- Kerns, J A -- Chen, Y -- Gantz, I -- Barsh, G S -- EY07106/EY/NEI NIH HHS/ -- GM07365/GM/NIGMS NIH HHS/ -- P30DK-34933/DK/NIDDK NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1997 Oct 3;278(5335):135-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pediatrics, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9311920" target="_blank"〉PubMed〈/a〉
Keywords:
Adrenal Glands/metabolism
;
Amino Acid Sequence
;
Animals
;
Female
;
Humans
;
Hypothalamus/metabolism
;
Male
;
Melanocyte-Stimulating Hormones/antagonists & inhibitors/pharmacology
;
Melanophores/metabolism
;
Mice
;
Mice, Inbred C57BL
;
Mice, Inbred CBA
;
Mice, Obese
;
Mice, Transgenic
;
Molecular Sequence Data
;
Obesity/etiology
;
Organophosphorus Compounds/pharmacology
;
Proteins/chemistry/genetics/pharmacology/*physiology
;
RNA/genetics/metabolism
;
Receptor, Melanocortin, Type 3
;
Receptor, Melanocortin, Type 4
;
Receptors, Corticotropin/*antagonists & inhibitors/metabolism
;
Receptors, Peptide/*antagonists & inhibitors/metabolism
;
Recombinant Proteins/metabolism
;
Signal Transduction
;
Xenopus
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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