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Basal cell carcinomas in mice overexpressing sonic hedgehog (1997)

A. E. Oro ; K. M. Higgins ; Z. Hu ; [weitere]

American Association for the Advancement of Science (AAAS)

In: Science. 276(5313): 817-21.

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Publikationsdatum: 1997-05-02

Beschreibung: Mutations in the tumor suppressor gene PATCHED (PTC) are found in human patients with the basal cell nevus syndrome, a disease causing developmental defects and tumors, including basal cell carcinomas. Gene regulatory relationships defined in the fruit fly Drosophila suggest that overproduction of Sonic hedgehog (SHH), the ligand for PTC, will mimic loss of ptc function. It is shown here that transgenic mice overexpressing SHH in the skin develop many features of basal cell nevus syndrome, demonstrating that SHH is sufficient to induce basal cell carcinomas in mice. These data suggest that SHH may have a role in human tumorigenesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Oro, A E -- Higgins, K M -- Hu, Z -- Bonifas, J M -- Epstein, E H Jr -- Scott, M P -- AR39959/AR/NIAMS NIH HHS/ -- New York, N.Y. -- Science. 1997 May 2;276(5313):817-21.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, Department of Dermatology, Stanford University School of Medicine, Stanford, CA 94305-5427, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9115210" target="_blank"〉PubMed〈/a〉

Schlagwort(e): Animals ; Basal Cell Nevus Syndrome/*genetics/metabolism/pathology ; Carcinoma, Basal Cell/*genetics/metabolism/pathology ; Embryo, Mammalian ; *Gene Expression Regulation, Neoplastic ; Hedgehog Proteins ; Humans ; Intracellular Signaling Peptides and Proteins ; Keratinocytes/metabolism ; Male ; Membrane Proteins/genetics/metabolism ; Mice ; Mice, SCID ; Mice, Transgenic ; Mutation ; Neoplasm Transplantation ; Protein Biosynthesis ; Proteins/*genetics/metabolism ; Receptors, Cell Surface ; Skin/pathology ; Skin Neoplasms/*genetics/metabolism/pathology ; Skin Transplantation ; *Trans-Activators

Print ISSN: 0036-8075

Digitale ISSN: 1095-9203

Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik

Publiziert von American Association for the Advancement of Science (AAAS)

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Digitale Medien

Magnetic field induced reversed (Negative) magnetization for electrochemically deposited Tc = 260 K Oxidized Films of Chromium Cyanide MagnetsWe gratefully acknowledge support from the US National Science Foundation, Grant no. CHE-9320478, Department of Energy, Division of Materials Science, Grant no. DE-FG02-86ER45271.A000, Department of Energy, Division of Advanced Energy Projects, Grant no. DE-FG02-96ER12198, and the Office of Naval Research. (1997)

Buschmann, Wayne E. ; Paulson, Scott C. ; Wynn, Charles M. ; [weitere]

Weinheim : Wiley-Blackwell

Advanced Materials 9 (1997), S. 645-647

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ISSN: 0935-9648

Schlagwort(e): Chemistry ; Polymer and Materials Science

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie , Maschinenbau , Physik

Zusätzliches Material: 3 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/adma.19970090812

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The Importance of Magnetic Coupling Through Atoms with Large Spin Densities - Structure and Magnetic Properties of meso-Tetrakis-(4′-tert-Butylphenyl)Porphinatomanganese(III) Hexacyanobutadienide, [MnIIITtBuPP]+[C4(CN)6].- (1997)

Sugiura, Ken-Ichi ; Arif, Atta M. ; Rittenberg, Durrell K. ; [weitere]

Weinheim : Wiley-Blackwell

Chemistry - A European Journal 3 (1997), S. 138-142

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ISSN: 0947-6539

Schlagwort(e): electron transfer ; magnetic properties ; metalloporphryins ; polymers ; spin density ; Chemistry ; General Chemistry

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: [MnIIITtBuPP]+[C4(CN)6].- · 5PhMe [MnIIITtBuPP = meso-tetrakis-(4′-tert-butylphenyl)porphinatomanganese(III)] has been prepared and structurally and magnetically characterized. The uniform, linear-chain (1-D) coordination polymer comprises alternating cations and anions. The bond lengths in planar ion [C4(CN)6].-]'- are 1.377(10) (CC-CC), 1.418(7) (C-CCC), 1.414 (C-CN), 1.457 (C-CNMn), 1.150 (C≡N), and 1.134 Å (C = NMn). The Mn-N-C angle is 172.3(4)°, and the intrachain Mn - Mn separation is 10.685 Å. Each [C4(CN)6].-]' unit is bonded to two MnIII atoms through the interior nitrogen atoms in a trans-μ2-N-σ manner with N-Mn bond lengths of 2.353 Å. The ṽCN absorptions are at 2217 (w, br) and 2190 (m) cm-1. Above 50 K the magnetic susceptibility of [MnIIITtBuPP]+[C4(CN)6].- can be fitted to the Curie-Weiss expression, χ∝1(T - θ), with an effective θ of -13 K. This is consistent with weak antiferromagnetic coupling, which is in contrast to the effective θ of +67 K for the uniform chain [MnIIIOEP]+[C4(CN)6].- [OEP = octaethylporphinato]. Here, the [C4(CN)6].-'- units are bonded to the MnIII centers through endo CN nitrogen atoms in a similar trans-μ2 manner. Density functional theory MO calculations reveal that the spin density of the CN nitrogen atom bound to [MnIIITtBuPP]+ (0.019 μBÅ-3) is significantly lower than that of the N atom bound to [MnIIIOEP]+ (0.102 μBÅ-3). This is consistent with the reduced spin coupling observed for [MnIIITtBuPP]+[C4(CN)6].-with respect to [MnIIITtBuPP]+[C4(CN)6].-, as evidenced by the lower θ value. The different orientations of the [C4(CN)6].- units - almost perpendicular (84.72°) for [MnIIITtBuPP]+[C4(CN)6].- and substantially tilted (32.1°) for [MnIIIOEP]+ [C4(CN)6].- may also contribute to the poorer overlap and weaker spin coupling. Hence, binding between sites with large spin densities is needed to stabilize strong ferromagnetic coupling.

Zusätzliches Material: 4 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/chem.19970030121

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Immobilized pH gradient two-dimensional gel electrophoresis and mass spectrometric identification of cytokine-regulated proteins in ME-180 cervical carcinoma cells (1997)

Matsui, Neil M. ; Smith, Diana M. ; Clauser, Karl R. ; [weitere]

Weinheim : Wiley-Blackwell

Electrophoresis 18 (1997), S. 409-417

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ISSN: 0173-0835

Schlagwort(e): Cervical carcinoma ; Two-dimensional polyacrylamide gel electrophoresis ; Mass spectrometry ; Immobilized pH gradient ; Cytokine ; Chemistry ; Biochemistry and Biotechnology

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Biologie , Chemie und Pharmazie

Notizen: Two-dimensional (2-D) polyacrylamide gel electrophoresis combined with mass spectrometry is a powerful combination of technologies that allows high resolution separation of proteins and their rapid identification. Immobilized pH gradient (IPG) first-dimensional gels have several advantages over carrier ampholyte isoelectric focusing, including a high degree of reproducibility, good protein spot resolution, and a selection of pH range. Here we demonstrate the utility and efficacy of combining IPG 2-D gel electrophoresis with mass spectrometry to identify interferon-γ- (IFN) and tumor necrosis factor (TNF)-regulated proteins in ME-180 cervical carcinoma cells. Three cytokine-regulated proteins have been identified, using imidazole-zinc-stained preparative IPG 2-D gels and in-gel tryptic digestion followed by matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF) mass spectrometry for determination of peptide masses and sequences: (1) triosephosphate isomerase, a glycolytic pathway enzyme, (2) proteasome subunit C3, which is important in protein degradation, and (3) Ran, a GTP-binding protein important in cell cycle regulation, protein import into the nucleus, and RNA export from the nucleus.

Zusätzliches Material: 5 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/elps.1150180315

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