ISSN:
1572-901X
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract Complexes, [M(HL)2], where M = PdII, PtII and HL = neutral 2-acetylpyridine-(2-methylthiosemicarbazone), 2-acetylpyridine-(4-methylthiosemicarbazone) and 2-acetylpyridine-(4-phenylthiosemicarbazone), as well as [M(HL)2]Cl3, where M = RuIII, RhIII and IrIII, have been prepared and characterized by elemental analyses, conductivity measurements, magnetic susceptibility measurements and spectroscopic (i.r., Raman, u.v.-vis. and 1H and 13C-n.m.r) studies. The ligands behave as neutral bidentate components in the PdII and PtII complexes, whereas in RuIII, RhIII and IrIII complexes the ligands exist as neutral tridentates. Various ligand and nephelauxetic parameters have been calculated for the metal complexes. The RuIII, RhIII and IrIII complexes are six-coordinate distorted octahedral, whereas PdII and PtII are four coordinated. The ligands and their platinum group complexes exhibit a potent cytotoxic activity against Ehrlich ascites tumour cells in vitro but appear to be more in vivo.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1018416624951
Permalink