Publication Date:
1997-01-10
Description:
In the developing Drosophila eye, differentiation is coordinated with synchronized progression through the cell cycle. Signaling mediated by the transforming growth factor-beta-related gene decapentaplegic (dpp) was required for the synchronization of the cell cycle but not for cell fate specification. DPP may affect cell cycle synchronization by promoting cell cycle progression through the G2-M phases. This synchronization is critical for the precise assembly of the eye.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Penton, A -- Selleck, S B -- Hoffmann, F M -- New York, N.Y. -- Science. 1997 Jan 10;275(5297):203-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉McArdle Laboratory for Cancer Research and Laboratory of Genetics, University of Wisconsin Medical School, Madison, WI 53706, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8985012" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Body Patterning
;
*Cell Cycle
;
Cell Differentiation
;
Cell Nucleus/ultrastructure
;
Cyclins/metabolism
;
Drosophila/*genetics/physiology
;
*Drosophila Proteins
;
Eye/cytology
;
Female
;
G1 Phase
;
G2 Phase
;
*Genes, Insect
;
Insect Proteins/*genetics/physiology
;
Male
;
Membrane Glycoproteins/genetics/physiology
;
Mitosis
;
Mutation
;
Photoreceptor Cells, Invertebrate/*cytology
;
Proteoglycans/genetics/physiology
;
Signal Transduction
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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