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  • Chemistry  (5)
  • HL-60 Cells  (1)
  • 2020-2023
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  • 1997  (6)
  • 1
    Electronic Resource
    Electronic Resource
    Binomial distribution in multistage extraction processes (1997)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 43 (1997), S. 2146-2147 
    Details
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aic.690430823
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  • 2
    Electronic Resource
    Electronic Resource
    Farnesyltransferase as a target for anticancer drug design (1997)
    New York : Wiley-Blackwell
    Biopolymers 43 (1997), S. 25-41 
    Details
    ISSN: 0006-3525
    Keywords: Ras ; signal transduction ; farnesyltransferase ; GTPase ; anticancer drug design ; peptidomimetics ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The currently understood function for Ras in signal transduction is in mediating the transmission of signals from external growth factors to the cell nucleus. Mutated forms of this GTP-binding protein are found in 30% of human cancers with particularly high prevalence in colon and pancreatic carcinomas. These mutations destroy the GTPase activity of Ras and cause the protein to be locked in its active, GTP bound form. As a result, the signaling pathways are activated, leading to uncontrolled tumor growth. Ras function in signaling requires its association with the plasma membrane. This is achieved by posttranslational farnesylation of a cysteine residue present as part of the CA1A2X carboxyl terminal tetrapeptide of all Ras proteins. The enzyme that recognizes and farnesylates the CA1A2X sequence, Ras farnesyltransferase (FTase), has become an important target for the design of inhibitors that might be interesting as antitumor agents. Several approaches have been taken in the search for in vivo active inhibitors of farnesyltransferase. These include the identification of natural products such as the chaetomellic and zaragozic acids that mimic farnesylpyrophosphate, bisubstrate transition state analogs combining elements of the farnesyl and tetrapeptide substrates and peptidomimetics that reproduce features of the carboxyl terminal tetrapeptide CA1A2X sequence. This last group of compounds has been most successful in showing highly potent inhibition of FTase and selective blocking of Ras processing in a range of Ras transformed tumor cell lines at concentrations as low as 100 nM. Certain peptidomimetics will also block tumor growth in various mouse models, with apparently few toxic side effects. These results suggest that farnesyltransferase inhibitors hold considerable promise as anticancer drugs in the clinic. © 1997 John Wiley & Sons, Inc. Biopoly 43: 25-41, 1997
    Additional Material: 15 Ill.
    Type of Medium: Electronic Resource
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    Paper (German National Licenses)
  • 3
    Electronic Resource
    Electronic Resource
    The reaction of active and stabilized phosphonium ylides with α,β-unsaturated carbonyl compounds [1] (1997)
    New York, NY [u.a.] : Wiley-Blackwell
    Heteroatom Chemistry 8 (1997), S. 157-164 
    Details
    ISSN: 1042-7163
    Keywords: Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The active ketenylidene-(2a) or thioketenylidenetriphenylphosphoranes (2b) react with 2-benzylidene-1,3-indandione (1), 5-benzylidenebarbituric acid (11), and 4-benzylidene-1,2-diphenyl-3,5-pyrazolidinedione (16) to give the corresponding pyranones and thioxopyranones (3a,b, 12a,b) and (17a,b), respectively. On the other hand, compounds 1 and 11 can be converted by reaction with the stabilized alkylidenephosphoranes 4a-e into the phosphoranylidenes 6a-e and 13a-e. Moreover, the oxaphosphinins 8 or 14 and the oxazaphosphinins 10 or 15 were obtained when compounds 1 and 11 were allowed to react with the phosphorane 7 and the iminophosphorane 9, respectively. Some of these new organophosphorus compounds are found to have insecticidal and molluscicidal properties against cotton leafworm Spodoptera littoralis larvae and Biomphalaria alexandrina snails. © 1997 John Wiley, & Sons, Inc.
    Additional Material: 2 Tab.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Synthesen und Strukturen von Aluminium-Fluor-Sauerstoff-ClusternProfessor Heribert Offermanns zum 60. Geburtstag gewidmetDiese Arbeit wurde von der Deutschen Forschungsgemeinschaft gefördert. (1997)
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 109 (1997), S. 2738-2739 
    Details
    ISSN: 0044-8249
    Keywords: Aluminium ; Cluster ; Fluor ; O-Liganden ; Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ange.19971092318
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  • 5
    Electronic Resource
    Electronic Resource
    Synthesis and Structure of Aluminum-Fluorine-Oxygen ClustersThis work was supported by the Deutsche Forschungsgemeinschaft.Dedicated to Professor Heribert Offermanns on the occasion of his 60th birthday (1997)
    Weinheim : Wiley-Blackwell
    Angewandte Chemie International Edition in English 36 (1997), S. 2625-2626 
    Details
    ISSN: 0570-0833
    Keywords: aluminum ; clusters ; fluorine ; O ligands ; Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/anie.199726251
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  • 6
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    Kaposi's sarcoma-associated herpesvirus infection of bone marrow dendritic cells from multiple myeloma patients (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-06-20
    Description: Kaposi's sarcoma-associated herpesvirus (KSHV) was found in the bone marrow dendritic cells of multiple myeloma patients but not in malignant plasma cells or bone marrow dendritic cells from normal individuals or patients with other malignancies. In addition the virus was detected in the bone marrow dendritic cells from two out of eight patients with monoclonal gammopathy of undetermined significance (MGUS), a precursor to myeloma. Viral interleukin-6, the human homolog of which is a growth factor for myeloma, was found to be transcribed in the myeloma bone marrow dendritic cells. KSHV may be required for transformation from MGUS to myeloma and perpetuate the growth of malignant plasma cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rettig, M B -- Ma, H J -- Vescio, R A -- Pold, M -- Schiller, G -- Belson, D -- Savage, A -- Nishikubo, C -- Wu, C -- Fraser, J -- Said, J W -- Berenson, J R -- New York, N.Y. -- Science. 1997 Jun 20;276(5320):1851-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Hematology and Oncology, Veterans Affairs West Los Angeles Medical Center, Los Angeles, CA 90073, USA. RETTIG.MATTHEW@WEST-LA.VA.GOV〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9188529" target="_blank"〉PubMed〈/a〉
    Keywords: Blotting, Southern ; Bone Marrow/pathology/*virology ; Cell Transformation, Neoplastic ; DNA, Viral/analysis ; Dendritic Cells/*virology ; HL-60 Cells ; Herpesvirus 8, Human/genetics/isolation & purification/*pathogenicity/physiology ; Humans ; In Situ Hybridization ; Interleukin-6/*analysis/genetics/physiology ; Multiple Myeloma/pathology/*virology ; Paraproteinemias/pathology/virology ; Polymerase Chain Reaction ; Stromal Cells/pathology/virology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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