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  • Molecular Diversity Preservation International  (15)
  • American Chemical Society  (4)
  • Inter-Research  (2)
  • American Association for the Advancement of Science (AAAS)  (1)
  • National Academy of Sciences
  • PANGAEA
  • 2020-2022  (20)
  • 1995-1999  (3)
  • 1950-1954
  • 2020  (20)
  • 1997  (3)
  • 1
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    Adult fast myosin pattern and Ca2+-induced slow myosin pattern in primary skeletal muscle culture (1997)
    National Academy of Sciences
    Details
    Publication Date: 1997-04-15
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 2
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    The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-02-21
    Description: In a cell-free apoptosis system, mitochondria spontaneously released cytochrome c, which activated DEVD-specific caspases, leading to fodrin cleavage and apoptotic nuclear morphology. Bcl-2 acted in situ on mitochondria to prevent the release of cytochrome c and thus caspase activation. During apoptosis in intact cells, cytochrome c translocation was similarly blocked by Bcl-2 but not by a caspase inhibitor, zVAD-fmk. In vitro, exogenous cytochrome c bypassed the inhibitory effect of Bcl-2. Cytochrome c release was unaccompanied by changes in mitochondrial membrane potential. Thus, Bcl-2 acts to inhibit cytochrome c translocation, thereby blocking caspase activation and the apoptotic process.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kluck, R M -- Bossy-Wetzel, E -- Green, D R -- Newmeyer, D D -- CA69381/CA/NCI NIH HHS/ -- GM50284/GM/NIGMS NIH HHS/ -- GM52735/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1997 Feb 21;275(5303):1132-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9027315" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Chloromethyl Ketones/pharmacology ; Animals ; *Apoptosis ; Carrier Proteins/metabolism ; Cell Extracts ; Cell-Free System ; Cysteine Endopeptidases/metabolism ; Cysteine Proteinase Inhibitors/pharmacology ; Cytochrome c Group/*metabolism ; Cytosol/metabolism ; Membrane Potentials ; Microfilament Proteins/metabolism ; Mitochondria/*metabolism ; Ovum ; Proto-Oncogene Proteins c-bcl-2/*metabolism/pharmacology ; Recombinant Proteins ; Xenopus
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Organizational Health Literacy in Facilities for People with Disabilities: First Results of an Explorative Qualitative and Quantitative Study (2020)
    Molecular Diversity Preservation International
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    Publication Date: 2020-04-22
    Description: To date, studies on individual and organizational health literacy (OHL) in facilities for people with disabilities are scarce. Thus, the aims of this study are (1) to adapt an existing instrument for measuring organizational health literacy (OHL), namely, the “Health literate health care organization scale” (HLHO-10), to the context of facilities for people with disabilities, (2) to quantitatively examine characteristics of OHL, and (3) to qualitatively assess the definition and role of OHL by interviewing managers and skilled staff. An online study in Germany with N = 130 managers and skilled staff in facilities for people with disabilities was conducted, using the adapted HLHO-10 questionnaire. Univariate analyses were applied. Qualitative content analysis was used to investigate interview data from N = 8 managers and skilled staff from N = 8 facilities for people with disabilities in Hesse, Germany. Quantitative results revealed that respondents reported a below-average level in HLHO-10, with the lowest level found in the attribute of participative development of health information. The qualitative findings showed a clear need for improved navigation to and in facilities. The quantitative and qualitative findings are mainly consistent. Future research and measures should focus on facilities for people with disabilities in order to strengthen the development of and access to target-group-specific health information, as well as to establish a health-literate working and living environment.
    Print ISSN: 1661-7827
    Electronic ISSN: 1660-4601
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Published by Molecular Diversity Preservation International
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  • 4
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    Modeling the Supply of Renewable Electricity to Metropolitan Regions in China (2020)
    Molecular Diversity Preservation International
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    Publication Date: 2020-06-12
    Description: The accelerated urbanization and industrialization in China is leading to major challenges due to rising energy demand and emissions. Cities in particular play an important role in the decision-making and implementation processes for the energy transition. However, they often have only limited local energy potential and are heavily dependent on supply regions. We therefore assess how a predominantly renewable power supply can be implemented based on the availability of local or imported renewable resources. We present a case study in which an advanced energy system model is parametrized and applied to address questions which are relevant to the transformation of the energy system in China. The model is capable of simultaneously optimizing investment decisions and hourly power balances of a scenario year, taking into account different storage technologies, regional power exchange and policy constraints such as carbon cap, carbon price and renewable portfolio standards. The study takes the Beijing-Tianjin-Hebei metropolitan region with Inner Mongolia as a supply region—considered as exemplary regions characterized by heterogeneous infrastructures, resources and consumption—as its model. Starting from a context-related normative energy scenario, we analyze a possible future electricity system under various assumptions using the Renewable Energy Mix (REMix) energy system model developed at the DLR (German Aerospace Center). Depending on the estimated potentials of renewable energies, technology costs and the projected electricity demand, the metropolitan region is mainly supplied with imported wind and solar power. A sensitivity analysis considers installed capacities, annual generation, CO2 emissions and costs. The results indicate that the assumption of storage costs is of great importance for the future total costs of an electricity system. Variations in other parameters led to different generation portfolios with similar system costs. Our results provide insights into future regional infrastructure needs, and underline the importance of regional coordination and governance for the energy transition in China.
    Electronic ISSN: 1996-1073
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Published by Molecular Diversity Preservation International
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  • 5
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    Effect of Fibre Material and Fibre Roughness on the Pullout Behaviour of Metallic Micro Fibres Embedded in UHPC (2020)
    Molecular Diversity Preservation International
    Details
    Publication Date: 2020-07-14
    Description: The use of micro fibres in Ultra-High-Performance Concrete (UHPC) as reinforcement increases tensile strength and especially improves the post-cracking behaviour. Without using fibres, the dense structure of the concrete matrix results in a brittle failure upon loading. To counteract this behaviour by fibre reinforcement, an optimal bond between fibre and cementitious matrix is essential. For the composite properties not only the initial surfaces of the materials are important, but also the bonding characteristics at the interfacial transition zone (ITZ), which changes upon the joining of both materials. These changes are mainly induced by the bond of cementitious phases on the fibre. In the present work, three fibre types were used: steel fibres with brass coating, stainless-steel fibres as well as nickel-titanium shape memory alloys (SMA). SMA fibres have the ability of “remembering” an imprinted shape (referred to as shape memory effect), triggered by thermal activation or stress, principally providing for superior performance of the fibre-reinforced UHPC. However, previous studies have shown that NiTi-fibres have a much lower bond strength to the concrete matrix than steel fibres, eventually leading to a deterioration of the mechanical properties of the composite. Accordingly, the bond between both materials has to be improved. A possible strategy is to roughen the fibre surfaces to varying degrees by laser treatment. As a result, it can be shown that laser treated fibres are characterised by improved bonding behaviour. In order to determine the bond strength of straight, smooth fibres of different metal alloy compositions, the present study characterized multiple fibres in series with a Compact-Tension-Shear (CTS) device. For critical evaluation, results obtained by these tests are compared with the results of conventional testing procedures, i.e., bending tests employing concrete prisms with fibre reinforcements. The bond behaviour is compared with the results of the flexural strength of prisms (4 × 4 × 16 cm3) with fibre reinforcements.
    Electronic ISSN: 1996-1944
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Published by Molecular Diversity Preservation International
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  • 6
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    Hydraulic and Mechanical Impacts of Pore Space Alterations within a Sandstone Quantified by a Flow Velocity-Dependent Precipitation Approach (2020)
    Molecular Diversity Preservation International
    Details
    Publication Date: 2020-07-11
    Description: Geochemical processes change the microstructure of rocks and thereby affect their physical behaviour at the macro scale. A micro-computer tomography (micro-CT) scan of a typical reservoir sandstone is used to numerically examine the impact of three spatial alteration patterns on pore morphology, permeability and elastic moduli by correlating precipitation with the local flow velocity magnitude. The results demonstrate that the location of mineral growth strongly affects the permeability decrease with variations by up to four orders in magnitude. Precipitation in regions of high flow velocities is characterised by a predominant clogging of pore throats and a drastic permeability reduction, which can be roughly described by the power law relation with an exponent of 20. A continuous alteration of the pore structure by uniform mineral growth reduces the permeability comparable to the power law with an exponent of four or the Kozeny–Carman relation. Preferential precipitation in regions of low flow velocities predominantly affects smaller throats and pores with a minor impact on the flow regime, where the permeability decrease is considerably below that calculated by the power law with an exponent of two. Despite their complete distinctive impact on hydraulics, the spatial precipitation patterns only slightly affect the increase in elastic rock properties with differences by up to 6.3% between the investigated scenarios. Hence, an adequate characterisation of the spatial precipitation pattern is crucial to quantify changes in hydraulic rock properties, whereas the present study shows that its impact on elastic rock parameters is limited. The calculated relations between porosity and permeability, as well as elastic moduli can be applied for upscaling micro-scale findings to reservoir-scale models to improve their predictive capabilities, what is of paramount importance for a sustainable utilisation of the geological subsurface.
    Electronic ISSN: 1996-1944
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Published by Molecular Diversity Preservation International
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  • 7
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    Fluorescence Microscopy of Superplasticizers in Cementitious Systems: Applications and Challenges (2020)
    Molecular Diversity Preservation International
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    Publication Date: 2020-08-24
    Description: In addition to the desired plasticizing effect, superplasticizers used in high and ultra-high performance concretes (UHPC) influence the chemical system of the pastes and for example retardation of the cement hydration occurs. Thus, superplasticizers have to be chosen wisely for every material composition and application. To investigate the essential adsorption of these polymers to particle surfaces in-situ to overcome several practical challenges of superplasticizer research, fluorescence microscopy is useful. In order to make the superplasticizer polymers visible for this microscopic approach, they are stained with fluorescence dyes prior the experiment. In this work, the application of this method in terms of retardation and rheological properties of sample systems is presented. The hydration of tricalcium oxy silicate (C3S) in combination with different polycarboxylate ether superplasticizers is observed by fluorescence microscopy and calorimetry. Both methods can identify the retarding effect, depending on the superplasticizer’s chemical composition. On the other hand, the influence of the superplasticizers on the slump of a ground granulated blast furnace slag/cement paste is correlated to fluorescence microscopic adsorption results. The prediction of the efficiency by microscopic adsorption analysis succeeds roughly. At last, the possibility of high-resolution imaging via confocal laser scanning microscopy is presented, which enables the detection of early hydrates and their interaction with the superplasticizers.
    Electronic ISSN: 1996-1944
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Published by Molecular Diversity Preservation International
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  • 8
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    MASH Explorer: A Universal Software Environment for Top-Down Proteomics (2020)
    American Chemical Society
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    Publication Date: 2020-08-04
    Print ISSN: 1535-3893
    Electronic ISSN: 1535-3907
    Topics: Chemistry and Pharmacology
    Published by American Chemical Society
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  • 9
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    Myocyte Enhancer Factor 2A (MEF2A) Defines Oxytocin-Induced Morphological Effects and Regulates Mitochondrial Function in Neurons (2020)
    Molecular Diversity Preservation International
    Details
    Publication Date: 2020-03-23
    Description: The neuropeptide oxytocin (OT) is a well-described modulator of socio-emotional traits, such as anxiety, stress, social behavior, and pair bonding. However, when dysregulated, it is associated with adverse psychiatric traits, such as various aspects of autism spectrum disorder (ASD). In this study, we identify the transcription factor myocyte enhancer factor 2A (MEF2A) as the common link between OT and cellular changes symptomatic for ASD, encompassing neuronal morphology, connectivity, and mitochondrial function. We provide evidence for MEF2A as the decisive factor defining the cellular response to OT: while OT induces neurite retraction in MEF2A expressing neurons, OT causes neurite outgrowth in absence of MEF2A. A CRISPR-Cas-mediated knockout of MEF2A and retransfection of an active version or permanently inactive mutant, respectively, validated our findings. We also identified the phosphatase calcineurin as the main upstream regulator of OT-induced MEF2A signaling. Further, MEF2A signaling dampens mitochondrial functioning in neurons, as MEF2A knockout cells show increased maximal cellular respiration, spare respiratory capacity, and total cellular ATP. In summary, we reveal a central role for OT-induced MEF2A activity as major regulator of cellular morphology as well as neuronal connectivity and mitochondrial functioning, with broad implications for a potential treatment of disorders based on morphological alterations or mitochondrial dysfunction.
    Print ISSN: 1661-6596
    Electronic ISSN: 1422-0067
    Topics: Chemistry and Pharmacology
    Published by Molecular Diversity Preservation International
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  • 10
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    Inhomogeneous Temperature Distribution Affecting the Cyclic Aging of Li-Ion Cells. Part I: Experimental Investigation (2020)
    Molecular Diversity Preservation International
    Details
    Publication Date: 2020-02-14
    Description: Alongside electrical loads, it is known that temperature has a strong influence on battery behavior and lifetime. Investigations have mainly been performed at homogeneous temperatures and non-homogeneous conditions in single cells have at best been simulated. This publication presents the development of a methodology and experimental setup to investigate the influence of thermal boundary conditions during the operation of lithium-ion cells. In particular, spatially inhomogeneous and transient thermal boundary conditions and periodical electrical cycles were superimposed in different combinations. This required a thorough design of the thermal boundary conditions applied to the cells. Unlike in other contributions that rely on placing cells in a climatic chamber to control ambient air temperature, here the cell surfaces and tabs were directly connected to individual cooling and heating plates. This improves the control of the cells’ internal temperature, even with high currents accompanied by strong internal heat dissipation. The aging process over a large number of electrical cycles is presented by means of discharge capacity and impedance spectra determined in repeated intermediate characterizations. The influence of spatial temperature gradients and temporal temperature changes on the cyclic degradation is revealed. It appears that the overall temperature level is indeed a decisive parameter for capacity fade during cyclic aging, while the intensity of a temperature gradient is not as essential. Furthermore, temperature changes can have a substantial impact and potentially lead to stronger degradation than spatial inhomogeneities.
    Electronic ISSN: 2313-0105
    Topics: Electrical Engineering, Measurement and Control Technology
    Published by Molecular Diversity Preservation International
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