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  • 1
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 381 (1996), S. 807-810 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Ubx specifies haltere and abdominal identities in the Drosophila epidermis. Mutations that reduce its activity (for example null alleles such as Ubx1, deletions of the locus, and some regulatory mutations; see Fig. la) transform these cells to wing13. In contrast, mutations that increase its ...
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    The journal of Fourier analysis and applications 5 (1999), S. 589-597 
    ISSN: 1531-5851
    Keywords: 42C15 ; 39B99 ; multivariate ; nonhomogeneous ; refinement
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract We give necessary and sufficient conditions for the existence and uniqueness of compactly supported distribution solutionsf=(f 1,...,f r)T of nonhomogeneous refinement equations of the form $$f(x) = h(x) + \sum\limits_{\alpha \in A} {c_\alpha f(2x - \alpha )(x \in R^s )} $$ , where h=(h1,...,hr)Tis a compactly supported vector-valued multivariate distribution, A⊂Z+ s has compact support, and the coefficientsc α are real-valued r×r matrices. In particular, we find a finite dimensional matrix B, constructed from the coefficientsc α of the equation (I−B)q=p, where the vectorp depends on h. Our proofs proceed in the time domain and allow us to represent each solution regardless of the spectral radius of P(0):=2−s∑c α , which has been a difficulty in previous investigations of this nature.
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  • 3
    ISSN: 1432-1432
    Keywords: Key words: Genome evolution — Adaptability — Somatic hypermutation — Affinity maturation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract. Darwinian theory requires that mutations be produced in a nonanticipatory manner; it is nonetheless consistent to suggest that mutations that have repeatedly led to nonviable phenotypes would be introduced less frequently than others—if under appropriate genetic control. Immunoglobulins produced during infection acquire point mutations that are subsequently selected for improved binding to the eliciting antigen. We and others have speculated that an enhancement of mutability in the complementarity-determining regions (CDR; where mutations have a greater chance of being advantageous) and/or decrement of mutability in the framework regions (FR; where mutations are more likely to be lethal) may be accomplished by differential codon usage in concert with the known sequence specificity of the hypermutation mechanism. We have examined 115 nonproductively rearranged human Ig sequences. The mutation patterns in these unexpressed genes are unselected and therefore directly reflect inherent mutation biases. Using a χ2 test, we have shown that the number of mutations in the CDRs is significantly higher than the number of mutations found in the FRs, providing direct evidence for the hypothesis that mutations are preferentially targeted into the CDRs.
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  • 4
    ISSN: 1572-9591
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Archives of environmental contamination and toxicology 36 (1999), S. 295-300 
    ISSN: 1432-0703
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Notes: Abstract. The input of selenium from subsurface agricultural drainage into surface water systems can result in the accumulation of toxic concentrations of selenium in aquatic food chains. Elevated selenium concentrations in aquatic systems is a significant environmental problem in many areas of the United States. A laboratory investigation was conducted to determine the dominant route of selenium bioaccumulation by the corixid Trichocorixa reticulata, an important food chain organism. The roles of waterborne and foodborne exposure in selenium bioaccumulation were examined using 48-h bioassays. Waterborne selenium concentrations ranged from 0 to 1,000 μg Se/L as selenate. A mixture of two species of blue-green algae cultured in media with selenium concentrations ranging from 0 to 1,000 μg Se/L as selenate was used as a corixid diet in the foodborne treatments. Corixids exposed to waterborne selenate did not accumulate selenium above control concentrations. Corixids fed algae exposed to ≥100 μg Se/L as selenate had significantly higher selenium concentrations than control organisms. These data suggest that corixids may be effectively isolated from the water and selenium accumulation is solely through dietary exposure.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Fresenius' journal of analytical chemistry 363 (1999), S. 185-188 
    ISSN: 1432-1130
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract 15N solid state NMR without enrichment is rarely used because of the low sensitivity and low natural abundance of this nucleus. As demonstrated on different nitrogen-containing polysilanes and polysilazanes, it can be shown that with the CP/MAS technique spectra can be obtained in good quality and within acceptable measuring time. Three main different nitrogen sites – NSi3, NSi2H and NSiH2– can be observed as well as changes in the intensities of these sites with reaction and tempering conditions. Thus the spectra give valuable additional information for a better understanding of the structures and their changes within the investigated systems.
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Semigroup forum 91 (1999), S. 671-675 
    ISSN: 1432-2137
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Lolium perenne L. cv. Regal and Pleasure) and tall fescue (Festuca arundinacea Schreb. cv. Martin and Rebel II). Seed yield components were measured to identify the components through which treatments affect yield. Treatments did not affect seed yield of Regal perennial ryegrass and Martin tall fescue in any crop year. Third-crop seed yield of Pleasure perennial ryegrass was 15% higher for the open-burn than for the flail-chop treatment; fourth-crop seed yield was 12% higher for the open-burn treatment than for either flail-chop or propane-burn. Across years, seed yields of Rebel II tall fescue for propane-burn and open-burn treatments were 8 and 12% greater, respectively, than for flail-chop. Where seed yields were affected, differences among treatments were through changes in seed number per unit area (seeds m-2), but seed weight was relatively stable. Treatments did not affect the number of fertile tillers in any cultivar. Variations in seed number were apparently due to treatment effects on the number of seeds set per tiller. We conclude that the need for postharvest residue burning in perennial ryegrass and tall fescue is cultivar specific. Mechanical residue removal is apparently as effective as open-field burning for maintaining high seed yields in some cultivars of these grasses.
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Environmental management 20 (1996), S. 865-872 
    ISSN: 1432-1009
    Keywords: Biodiversity ; Ecosystem management ; Ecological stewardship ; Sustainable development ; Assessment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract The project on Biodiversity Uncertainties and Research Needs (BURN) ensures the advancement of usable knowledge on biodiversity by obtaining input from decision makers on their priority information needs about biodiversity and then using this input to engage leading scientists in designing policy-relevant research. Decision makers articulated concerns related to four issues: significance of biodiversity; status and trends of biodiversity; management for biodiversity; and the linkage of social, cultural, economic, legal, and biological objectives. Leading natural and social scientists then identified the research required to address the decision makers' needs and determined the probability of success. The diverse group of experts reached consensus on several fundamental issues, helping to clarify the role of biodiversity in land and resource management. The BURN participants identified several features that should be incorporated into policy-relevant research plans and management strategies for biodiversity. Research and assessment efforts should be: multidisciplinary and integrative, participatory with stakeholder involvement, hierarchical (multiple scales), and problem- and region-specific. The activities should be focused regionally within a global perspective. Meta-analysis of existing data is needed on all fronts to assess the state of the science. More specifically, the scientists recommended six priority research areas that should be pursued to address the information needs articulated by decision makers: (1) characterization of biodiversity, (2) environmental valuation, (3) management for sustainability—for humans and the environment (adaptive management), (4) information management strategies, (5) governance and stewardship issues, and (6) communication and outreach. Broad recommendations were developed for each research area to provide direction for research planning and resource management strategies. The results will directly benefit those groups that require biodiversity research to address their needs—whether to develop policy, manage natural resources, or make other decisions affecting biodiversity.
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Environmental management 20 (1996), S. 865-872 
    ISSN: 1432-1009
    Keywords: KEY WORDS: Biodiversity; Ecosystem management; Ecological stewardship; Sustainable development; Assessment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Immunogenetics 44 (1996), S. 485-486 
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
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