ISSN:
1075-4261
Keywords:
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Biology
,
Physics
Notes:
Spectroscopic technique coupled with electrochemical oxidation has been used to study the redox-mechanism of 6-mercaptopurine. Electrochemical oxidation of 6-mercaptopurine has been studied in the pH range 2.0-10.0 by linear and cyclic sweep voltammetry, coulometry and constant potential electrolysis. Spectroscopic technique has been used to monitor the clevage of the S—S bond in the UV-absorbing intermediate generated during electrooxidation. The decay has been observed in a pseudo first order reaction. The ultimate products of oxidation in controlled potential electrolysis have been found as 6-mercaptopurine and purine-6-sulfinic acid. Tentative mechanisms for the formation of the products have also been suggested. It is concluded that spectroscopic studies coupled with electrochemical studies provide a uniquely invaluable insight into the redox mechanism of biologically significant molecules. © 1995 John Wiley & Sons, Inc.
Additional Material:
7 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/bspy.350010110
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