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  • Capillary electrophoresis  (8)
  • Springer  (8)
  • 1995-1999  (8)
  • 1980-1984
  • 1970-1974
  • 1940-1944
  • 1995  (8)
Collection
Keywords
Publisher
Years
  • 1995-1999  (8)
  • 1980-1984
  • 1970-1974
  • 1940-1944
Year
  • 1
    Electronic Resource
    Electronic Resource
    Inter-company cross validation exercise on capillary electrophoresis. Quantitative determination of drug counter-ion level (1995)
    Springer
    Chromatographia 40 (1995), S. 47-50 
    Details
    ISSN: 1612-1112
    Keywords: Capillary electrophoresis ; Quantitative determination ; Sodium ; Cephalothin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary A capillary electrophoresis (CE) method for the quantitative determination of sodium levels in the sodium salt of an acidic drug has been transferred across 6 independent pharmaceutical companies. All companies were able to demonstrate similar selectivity and acceptable precision for migration times and relative migration times. Five companies obtained acceptable precision for the repeatability of response factors from repeated injections of calibration solutions. Highly variable results from the sixth company indicated problems arising from contamination from residual sodium, possibly from unclean glassware or autosampler vials. The quantitative assay results from all companies confirmed the correct drug: counter-ion ratio. The average % w/w sodium content was 5.45% which represents 99.0% of the theoretical sodium content of sodium cephalothin
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02274607
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  • 2
    Electronic Resource
    Electronic Resource
    Capillary electrophoretic separation of basic drugs using surface-modified C8 capillaries and derivatized cyclodextrins as structural/chiral selectors (1995)
    Springer
    Chromatographia 40 (1995), S. 697-704 
    Details
    ISSN: 1612-1112
    Keywords: Capillary electrophoresis ; Surface modified capillaries ; Derivatized cyclodextrins ; Peak shape optimisation ; Enantiomer and rotamer resolution ; Remoxipride and local anaesthetic drugs
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary Dynamic coating of bonded C8 fused silica capillaries with cationic amphiphiles is shown to minimize adsorption of basic drug molecules but also to facilitate control/reversal of electroosmotic flow. Optimization of the peak shapes was achieved by addition of cationic amphiphiles with a suitable mobility and adsorption to the capillary surface. The surface modification described, combined with the addition of cyclodextrins as selectors into the background electrolyte, resulted in unique CE systems showing excellent resolution for structural analogues. The separation of rotamers and enantiomers is demonstrated. Applications to the antipsychotic compound remoxipride and its related substances and to the chiral separation of asthma- and local anaesthetic drug enantiomers are given.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02315140
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  • 3
    Electronic Resource
    Electronic Resource
    Trace analysis of detergent residues by capillary electrophoresis (1995)
    Springer
    Chromatographia 40 (1995), S. 527-531 
    Details
    ISSN: 1612-1112
    Keywords: Capillary electrophoresis ; Trace analysis ; Dodecylbenzenesulphonate ; Detergent ; Validation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary A capillary electrophoresis (CE) method is reported which allows both specific and sensitive detection of the surfactant sodium dodecylbenzenesulphonate (SDBS) at a trace level. The method employs a simple high pH electrolyte with detection at 200 nm. This method has been applied to the monitoring of detergent residues on pharmaceutical processing equipment left after cleaning. Successful validation of the method demonstrated acceptable levels of sensitivity, recovery, precision, repeatability, robustness, detector linearity and stability of standards, reagents and samples. The CE method for determination of detergent residue was demonstrated to be selective with no interference from dissolving water or from cotton wool extracts. The method is rapid and both simple and easy to perform, and is now routinely applied to monitor detergent residues following product manufacture.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02290263
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  • 4
    Electronic Resource
    Electronic Resource
    Practical and quantitative aspects in the analysis of FITC and DTAF amino acid derivatives by capillary electrophoresis and LIF detection (1995)
    Springer
    Chromatographia 40 (1995), S. 519-526 
    Details
    ISSN: 1612-1112
    Keywords: Capillary electrophoresis ; Laser induced fluorescence (LIF) detection ; Amino acid analysis ; FITC and DTAF derivatives
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary Practical aspects related to the preparation of the fluorescein isothiocyanate (FITC) and dichlorotriazinylaminofluorescein (DTAF) derivatives of amino acids for purposes of quantitative analysis are examined and factors affecting quantification are discussed. It is shown that the labelling reaction for both reagents can be speeded up by operating at 40°C. The difficulties with derivatizing amino acids at detectable concentrations are highlighted. In spite of the high sensitivity of CE-LIF, detection sensitivity in real applications is limited by factors external to the analytical process, such as the label chemistry.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02290262
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  • 5
    Electronic Resource
    Electronic Resource
    Approaches to optimisation of precision in capillary electrophoresis (1995)
    Springer
    Chromatographia 40 (1995), S. 313-320 
    Details
    ISSN: 1612-1112
    Keywords: Capillary electrophoresis ; Repeatability ; Precision optimisation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary A study has been performed to obtain insight into the relative importance of critical factors affecting the repeatability of hydrodynamic injections in CE. Precision was measured for repeated analysis of a test mixture containing two acidic compounds. The use of an internal standard was clearly shown to improve precision especially when peak area precision was poor. It is suggested that precision is maximised by employing a combination of a constant temperature, an appropriate electrolyte system, an internal standard, long injection times, and high sample concentrations. Other factors are discussed, but are classified as having only a minor impact.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02290363
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  • 6
    Electronic Resource
    Electronic Resource
    Analysis of dissolution test sample solutions by high speed capillary electrophoresis (1995)
    Springer
    Chromatographia 41 (1995), S. 393-397 
    Details
    ISSN: 1612-1112
    Keywords: Capillary electrophoresis ; High speed analysis ; Dissolution testing ; Pharmaceuticals
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary The quantitative use of high speed capillary electrophoresis (HSCE) is examined by applying high voltages across short capillaries. Acceptable performance in terms of injection precision and migration times were achieved within 1–2 minute analysis times. HSCE was used for the novel CE application of dissolution test sample solution analysis. The results generated by HSCE compared well with those generated using validated on-line UV absorbance measurements. It is concluded that HSCE is a viable alternative and supplement to standard analytical methods employed in dissolution test analysis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02318611
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  • 7
    Electronic Resource
    Electronic Resource
    Separation and determination of 10-hydroxy-2-decenoic acid in royal jelly by capillary electrophoresis (1995)
    Springer
    Chromatographia 41 (1995), S. 605-609 
    Details
    ISSN: 1612-1112
    Keywords: Capillary electrophoresis ; 10-Hydroxy-2-decenoic acid ; Royal jelly
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary The application of capillary electrophoresis (CE) to the separation and determination of the active ingredient, 10-hydroxy-2-decenoic acid, in royal jelly with direct on-column UV detection at 214 nm is described. Using a cathodic injection and anodic detection scheme, 10-hydroxy-2-decenoic acid (10-HDA) was separated and detected in less than 10 min in a fused silica capillary column with a phosphate buffer at pH 7.3 with an applied voltage of 20 KV followed by direct UV detection. The use of cetyltrimethylammonium bromide (CTAB) as electroosmotic flow modifier allows the rapid separation of 10-HDA from other constituents in royal jelly by reversing the direction of electroosmotic flow. The influence of organic solvents in the electrolyte on separation selectivity is also discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02269727
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  • 8
    Electronic Resource
    Electronic Resource
    An evaluation of the use of capillary electrophoresis to monitor trace drug residues following the manufacture of pharmaceuticals (1995)
    Springer
    Chromatographia 40 (1995), S. 23-27 
    Details
    ISSN: 1612-1112
    Keywords: Capillary electrophoresis ; Cleaning qualification ; Trace level analysis ; Pharmaceuticals
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary The novel use of capillary electrophoresis to the important and developing area of monitoring possible drug residues on pharmaceutical manufacturing equipment is reported. The CE method is applicable to a wide range of basic drugs with sensitivity as low as 25ng/ml (equivalent to 8×10−8 M). This sensitivity is equivalent to that obtainable for HPLC for the drugs tested and is obtained by employing a combination of a wider bore capillary with low wavelength UV detection. Preliminary evaluation of the method performance shows acceptable precision, linearity, sensitivity and accuracy. Features of the method compared to HPLC include simplicity, ease of method transfer, reductions in analysis set-up time, and reduced costs of solvents and columns.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02274602
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