Publication Date:
1995-04-07
Description:
The expansion and contraction of specific helper T cells in the draining lymph nodes of normal mice after injection with antigen was followed. T cell receptors from purified primary and memory responder cells had highly restricted junctional regions, indicating antigen-driven selection. Selection for homogeneity in the length of the third complementarity-determining region (CDR3) occurs before selection for some of the characteristic amino acids, indicating the importance of this parameter in T cell receptor recognition. Ultimately, particular T cell receptor sequences come to predominate in the secondary response and others disappear, showing the selective preservation or expansion of specific T cell clones.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McHeyzer-Williams, M G -- Davis, M M -- New York, N.Y. -- Science. 1995 Apr 7;268(5207):106-11.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Microbiology and Immunology, Stanford University School of Medicine, CA 94305, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7535476" target="_blank"〉PubMed〈/a〉
Keywords:
Adjuvants, Immunologic
;
Amino Acid Sequence
;
Animals
;
Antigens/*immunology
;
Antigens, CD44
;
Base Sequence
;
Carrier Proteins/biosynthesis
;
Cell Adhesion Molecules/biosynthesis
;
Immunologic Memory/*immunology
;
L-Selectin
;
Lymphocyte Activation/immunology
;
Mice
;
Molecular Sequence Data
;
Receptors, Antigen, T-Cell, alpha-beta/biosynthesis/chemistry
;
Receptors, Cell Surface/biosynthesis
;
Receptors, Lymphocyte Homing/biosynthesis
;
T-Lymphocytes, Helper-Inducer/*immunology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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