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  • Springer  (15)
  • American Geophysical Union  (4)
  • American Chemical Society  (2)
  • American Institute of Physics (AIP)  (1)
  • 1995-1999  (22)
  • 1990-1994
  • 1880-1889
  • 1997  (11)
  • 1995  (11)
  • 1
    Digitale Medien
    Digitale Medien
    Host-cell-specific glycosylation of HIV-2 envelope glycoprotein (1997)
    Springer
    Glycoconjugate journal 14 (1997), S. 785-793 
    Details
    ISSN: 1573-4986
    Schlagwort(e): glycoprotein ; glycosylation ; gp120 ; HIV ; MALDI-TOF-MS
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract Neutral complex-type N-glycans of the envelope glycoprotein 120 of HIV-2, propagated in different host cells, display cell-type specific variations. In order to identify typical structural elements, glycans were analysed by gel filtration, by enzymic sequencing and, in part, by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. The characteristic substituents of di- tri- and tetraantennary carbohydrate units thus observed include N-acetyllactosamine repeats, bisecting N-acetylglucosamine and fucose linked to the chitobiose core as well as to N-acetyllactosamine antennae. Each glycoprotein preparation displayed a characteristic set of glycoforms. Abbreviations: endo H, endo-β-N-acetylglucosaminidase H; E-PHA, Phaseolus vulgaris agglutinin E4; GlcNAcOH, N-acetyl-glucosaminitol; gp120/HUT78(MOLT4/Mφ/PBL/U937), external envelope glycoprotein 120 of HIV-2, strain D194, propagated in HUT78 (MOLT4, Mφ, PBL, U937) cells; gu, glucose units; HPAEC, high-pH anion-exchange chromatography; MALDI-TOF-MS, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry; Mφ, human monocytes/macrophages; PBL, human peripheral blood lymphocytes; PNGase F, peptide-N4-(N-acetyl-β-glucosaminyl)asparagine amidase F
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1018577619036
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  • 2
    Digitale Medien
    Digitale Medien
    Surface roughening and columnar growth of thin amorphous CuTi films (1997)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 70 (1997), S. 1691-1693 
    Details
    ISSN: 1077-3118
    Quelle: AIP Digital Archive
    Thema: Physik
    Notizen: Different growth stages and the microstructure of amorphous CuTi films are investigated by scanning tunneling microscopy and small angle neutron scattering. During film growth at room temperature, the initially smooth films show increasing surface roughening and finally a change to a columnar growth mode with column diameters of about 20 nm. The interfacial energies associated with the column boundaries are higher than those of grain boundaries in crystalline systems. The column boundaries might be the origin of high intrinsic tensile stresses measured before in the amorphous CuTi films. © 1997 American Institute of Physics.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1063/1.118671
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  • 3
    Digitale Medien
    Digitale Medien
    Influence of management on butterflies of rare grassland ecosystems in Germany (1997)
    Springer
    Journal of insect conservation 1 (1997), S. 125-130 
    Details
    ISSN: 1572-9753
    Schlagwort(e): grazing ; mowing ; fens ; hay-meadows ; conservation.
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Wissenschaftskunde und Wissenschaftsorganisation, Hochschul- und Universitätswesen, Museumswissenschaft
    Notizen: Abstract Traditional hay-meadows in the Alps and fens at the edge of the Alps are habitats for many rare and endangered butterfly species. Conservation efforts aim at preserving these species, but the biotopes depend on regular mowing, which in turn requires intensive financial support. The feasibility of substituting mowing of these sites by grazing is discussed and considered as a more cost effective management type which produces agriculturally valuable goods as well. In this study the butterfly fauna of mown and grazed sites were compared. Species composition, species number, and the occurrence of rare species under the two management types were in most cases rather similar for both grassland ecosystems. Nevertheless, there are hints that for single rare species this might not be true. Additionally, at one site, grazing intensity on a former hay-meadow was too high to preserve the species-rich community. Overall the results are encouraging: grazing does not have to be as detrimental as formerly thought, although details (compartments of pastures, intensity) still have to be confirmed. Experimental grazing management of aban-doned grasslands of the studied types should be started.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1018443412153
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  • 4
    Digitale Medien
    Digitale Medien
    AURELIA, a program for computer-aided analysis of multidimensional NMR spectra (1995)
    Springer
    Journal of biomolecular NMR 6 (1995), S. 255-270 
    Details
    ISSN: 1573-5001
    Schlagwort(e): Multidimensional NMR ; Pattern recognition
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie
    Notizen: Summary AURELIA is an advanced program for the computer-aided evaluation of two-, three- and four-dimensional NMR spectra of any type of molecule. It can be used for the analysis of spectra of small molecules as well as for evaluation of complicated spectra of biological macromolecules such as proteins. AURELIA is highly interactive and offers a large number of tools, such as artefact reduction, cluster and multiplet analysis, spin system searches, resonance assignments, automated calculation of volumes in multidimensional spectra, calculation of distances with different approaches, including the full relaxation matrix approach, Bayesian analysis of peak features, correlation of molecular structures with NMR data, comparison of spectra via spectral algebra and pattern match techniques, automated sequential assignments on the basis of triple resonance spectra, and automatic strip calculation. In contrast to most other programs, many tasks are performed automatically.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00197807
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  • 5
    Digitale Medien
    Digitale Medien
    Structural analysis of neutral glycosphingolipids from Ascaris suum adults (Nematoda: Ascaridida) (1997)
    Springer
    Glycoconjugate journal 14 (1997), S. 389-399 
    Details
    ISSN: 1573-4986
    Schlagwort(e): arthro-series glycosphingolipids ; Ascaris suum ; (iso-branched) C17 sphingoid-bases ; neutral glycosphingolipids ; parasitic nematodes
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract The neutral glycosphingolipid fraction from adults of the pig parasitic nematode, Ascaris suum, was resolved into four components on thin-layer chromatography. The high-performance liquid chromatography-isolated components were structurally analysed by: methylation analysis; exoglycosidase cleavage; gas-liquid chromatography/mass spectrometry; liquid secondary-ion mass spectrometry; and, in particular, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Their chemical structures were determined as: Glc(β1-1)ceramide, Man(β1-4)Glc(β1-1)ceramide, GlcNAc(β1-3)Man(β1-4)Glc(β1-1)ceramide and Gal(α1-3)GalNAc(β1-4)GlcNAc(β1-3)Man(β1-4)Glc(β1-1)ceramide; and were characterized as belonging to the arthro-series of protostomial glycosphingolipids. No glycosphingolipid component corresponding to ceramide tetrasaccharide was detected during these analyses. The ceramide composition of the parent glycosphingolipids was dominated by the 2-(R)-hydroxy C24:0 fatty acid, cerebronic acid, and C17 sphingoid-bases: 15-methylhexadecasphing-4-enine and 15-methylhexadecaphinganine in approximately equal proportions. The component ceramide monohexoside was characterized by an additional 15-methylhexadecaphytosphingosine. Abbreviations: CDH, ceramide dihexoside; Cer, ceramide; CMH, ceramide monohexoside; CPH, ceramide pentahexoside; CTH, ceramide trihexoside; CTetH, ceramide tetrahexoside; Hex, hexose; HexNAc, N-acetylhexosamine; HPTLC, high-performance thin-layer chromatography; LSIMS, liquid secondary-ion mass spectrometry; MALDI-TOF-MS, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry; N-, Nz- and A-glyco(sphingo)lipids, neutral, neutralzwitterionic and acidic glyco(sphingo)lipids, respectively
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1018530914067
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  • 6
    Digitale Medien
    Digitale Medien
    A phase II study of thioTEPA in children with recurrent solid tumor malignancies: a Children's Cancer Group study (1995)
    Springer
    Investigational new drugs 13 (1995), S. 337-342 
    Details
    ISSN: 1573-0646
    Schlagwort(e): thioTEPA ; alkylating agents ; sarcomas ; chemotherapy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary A Phase II study of thioTEPA was performed by the Children's Cancer Group. ThioTEPA was administered intravenously every three weeks, at a dose of 65 mg/m2. Pediatric patients with recurrent sarcomas were targeted, but patients with other tumor diagnoses were also eligible. Toxicity was primarily hematopoietic, with thrombocytopenia being predominant. ThioTEPA did not demonstrate significant activity in the target tumor groups evaluated.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00873141
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  • 7
    Digitale Medien
    Digitale Medien
    Slicing the Oppenheimer-Snyder Collapse: Harmonic versus Maximal Slicing (1997)
    Springer
    General relativity and gravitation 29 (1997), S. 1257-1268 
    Details
    ISSN: 1572-9532
    Schlagwort(e): NUMERICAL RELATIVITY
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Physik
    Notizen: Abstract In continuing our studies of temporal slicings of spacetimes, we consider the collapse from rest of an initially homogeneous dust sphere, known as Oppenheimer-Snyder collapse. It is shown that in the case of harmonic slicing the whole spacetime becomes covered by slices extending to spatial infinity in contrast to maximal slicing. The behavior of the lapse function is discussed, especially for various data on the initial slice, and it is demonstrated that not every choice of the initial lapse leads to meaningful slicings.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1018811829719
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  • 8
    Digitale Medien
    Digitale Medien
    Observation of antihydrogen production in flight at CERN (1997)
    Springer
    Hyperfine interactions 109 (1997), S. 191-203 
    Details
    ISSN: 1572-9540
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Physik
    Notizen: Abstract The observation of the production of antihydrogen atoms \overlineH 0\equiv\barpe+, the simplest atomic bound state of antimatter, is presented. A method has been used by the PS210 collaboration at LEAR which assumes that the production of \overlineH0 is predominantly mediated by the e+e--pair creation via the two-photon mechanism in the antiproton--nucleus interaction. Neutral \overlineH0 atoms are indentified by a unique sequence of characteristics. In principle \overlineH0 is well suited for investigations of fundamental CPT violation studies under different forces, however, in our investigations we concentrate on the production of this antimatter object, since so far it had not been observed. The production of eleven antihydrogen atoms is reported including possibly 2± 1 background signals, the observed yield agrees with theoretical predictions.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1012609601849
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  • 9
    Digitale Medien
    Digitale Medien
    Bovine cysticercosis: demonstration in experimentally infected calves of serum IgG antibodies reactive with neutral glycolipids ofTaenia saginata andT. crassiceps metacestodes (1995)
    Springer
    Parasitology research 81 (1995), S. 18-25 
    Details
    ISSN: 1432-1955
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Abstract The immunoreactivity ofTaenia saginata andT. crassiceps metacestode neutral glyco(sphingo)lipids towards IgG antibodies derived from the sera of calves with experimental cysticercosis has been established. The glyco(sphingo)lipids are separable by normal-phase HPTLC (high-performance thin-layer chromatography) into groups of increasing sugar-chain length (lipid/ceramide mono-, di-, tri-, tetra- and 〉tetrasaccharides), with those corresponding to three and four hexoses being the main immunoreactive components (HPTLC immunostaining). In ELISA (enzyme-linked immunosorbent assay), reverse-phase HPTLC-isolatedT. crassiceps metacestode glyco(sphingo)lipids equivalent to tri- and tetrahexoside allowed a discrimination between non-infected and infected calves (at least 80 metacestodes recovered). The formation of IgG antibodies was correlated with the infection, not with other non-specific inducing factors, as seen by the differential humoral response detected in experimentally infected (T. saginata) calves before and after Praziquantel treatment (HPTLC immunostaining and ELISA).
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00932412
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  • 10
    Digitale Medien
    Digitale Medien
    Design of superactive and selective integrin receptor antagonists containing the RGD sequence (1995)
    Springer
    International journal of peptide research and therapeutics 2 (1995), S. 155-160 
    Details
    ISSN: 1573-3904
    Schlagwort(e): Cell-cell interaction ; Inhibition ; Rational design of spatial structures ; β-Turn mimetics ; Peptidomimetics ; Retro-inverso peptides ; Sugar amino acids in cyclic peptides
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary Integrins play a major role in cell-cell and cell-matrix interactions. The majority of the different types of integrins recognize the tripeptide sequence arginine-glycine-aspartic acid (RGD). To explore the spatial requirements of the pharmacophore for receptor selectivity and high activity, a new procedure, ‘spatial screening’, was used. The procedure is based on the experience that the conformation of small cyclic peptides is mainly determined by the chirality of the amino acids (and glycine or proline). For example, cyclic pentapeptides with one d and four l amino acids prefer a βII'/γ conformation. The sequence RGDFV was shifted around this spatial βII'/γ template by synthesis of five peptides in which one of the amino acids was used in d-configuration. It turned out that cyclo(-RGDfV-) is a selective inhibitor for the αvβ3 integrin, which is strongly expressed in cancer cells. Systematic variations with different turn mimetics, retro-inverso structures, modified peptide bonds and sugar amino acids are discussed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00119142
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