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  • 1
    Electronic Resource
    Electronic Resource
    Binomial distribution in multistage extraction processes (1997)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 43 (1997), S. 2146-2147 
    Details
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aic.690430823
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  • 2
    Electronic Resource
    Electronic Resource
    Electromagnetic Imaging Using Mutual Inductance Tomography: Potential for process applications (1995)
    Weinheim : Wiley-Blackwell
    Particle and Particle Systems Characterization 12 (1995), S. 68-74 
    Details
    ISSN: 0934-0866
    Keywords: Chemistry ; Industrial Chemistry and Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Process Engineering, Biotechnology, Nutrition Technology
    Notes: An overview of Electro-Magnetic Tomography (EMT) using mutual inductance measurements is presented. The paper reviews the technique and principle of operation and gives a description of three case studies, which cover some of the generic design considerations and which illustrate the potential variety for inductive EMT systems. Results from the systems are described. These systems are presently experimental and possible future developments and applications are discussed.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ppsc.19950120204
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  • 3
    Electronic Resource
    Electronic Resource
    Farnesyltransferase as a target for anticancer drug design (1997)
    New York : Wiley-Blackwell
    Biopolymers 43 (1997), S. 25-41 
    Details
    ISSN: 0006-3525
    Keywords: Ras ; signal transduction ; farnesyltransferase ; GTPase ; anticancer drug design ; peptidomimetics ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The currently understood function for Ras in signal transduction is in mediating the transmission of signals from external growth factors to the cell nucleus. Mutated forms of this GTP-binding protein are found in 30% of human cancers with particularly high prevalence in colon and pancreatic carcinomas. These mutations destroy the GTPase activity of Ras and cause the protein to be locked in its active, GTP bound form. As a result, the signaling pathways are activated, leading to uncontrolled tumor growth. Ras function in signaling requires its association with the plasma membrane. This is achieved by posttranslational farnesylation of a cysteine residue present as part of the CA1A2X carboxyl terminal tetrapeptide of all Ras proteins. The enzyme that recognizes and farnesylates the CA1A2X sequence, Ras farnesyltransferase (FTase), has become an important target for the design of inhibitors that might be interesting as antitumor agents. Several approaches have been taken in the search for in vivo active inhibitors of farnesyltransferase. These include the identification of natural products such as the chaetomellic and zaragozic acids that mimic farnesylpyrophosphate, bisubstrate transition state analogs combining elements of the farnesyl and tetrapeptide substrates and peptidomimetics that reproduce features of the carboxyl terminal tetrapeptide CA1A2X sequence. This last group of compounds has been most successful in showing highly potent inhibition of FTase and selective blocking of Ras processing in a range of Ras transformed tumor cell lines at concentrations as low as 100 nM. Certain peptidomimetics will also block tumor growth in various mouse models, with apparently few toxic side effects. These results suggest that farnesyltransferase inhibitors hold considerable promise as anticancer drugs in the clinic. © 1997 John Wiley & Sons, Inc. Biopoly 43: 25-41, 1997
    Additional Material: 15 Ill.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Resolution effects of organic additives on the MEKC enantiomeric separations of tri aza aromatic ligand compounds of iron(II) (1995)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Microcolumn Separations 7 (1995), S. 199-206 
    Details
    ISSN: 1040-7685
    Keywords: micellar electrokinetic chromatography ; capillary electrophoresis ; bile salts ; metal-ligands ; chiral separations ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: We have utilized micellar electrokinetic chromatography with sodium deoxycholate micelles to separate the enantiomers of bis(8-((pyridine-2-methylene)amino)quinoline)iron(II) hexafluorophosphate, Fe(PMAQ)2(PF6)2, bis(8-((pyridine-2-methylene)amino)lepidine iron(II) hexafluorophosphate, Fe(PMAL)2(PF6)2, and bis(1-(2-pyridinyl)ethylidine)-8-aminoquinoline iron(II) hexafluorophosphate, Fe(PEAQ)2(PF6)2. The influence of 13 water miscible organic additives on the resolution of each pair of enantiomers was investigated. Significant changes in resolution are seen depending upon the particular organic additive used in the separation buffer. In addition, the effects of acetone concentration on the resolution of these enantiomers in bile salt solution was investigated. Resolution for all three pairs of enantiomers is maximized in a buffer solution containing 15% acetone. © 1995 John Wiley & Sons, Inc.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mcs.1220070303
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  • 5
    Electronic Resource
    Electronic Resource
    The reaction of active and stabilized phosphonium ylides with α,β-unsaturated carbonyl compounds [1] (1997)
    New York, NY [u.a.] : Wiley-Blackwell
    Heteroatom Chemistry 8 (1997), S. 157-164 
    Details
    ISSN: 1042-7163
    Keywords: Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The active ketenylidene-(2a) or thioketenylidenetriphenylphosphoranes (2b) react with 2-benzylidene-1,3-indandione (1), 5-benzylidenebarbituric acid (11), and 4-benzylidene-1,2-diphenyl-3,5-pyrazolidinedione (16) to give the corresponding pyranones and thioxopyranones (3a,b, 12a,b) and (17a,b), respectively. On the other hand, compounds 1 and 11 can be converted by reaction with the stabilized alkylidenephosphoranes 4a-e into the phosphoranylidenes 6a-e and 13a-e. Moreover, the oxaphosphinins 8 or 14 and the oxazaphosphinins 10 or 15 were obtained when compounds 1 and 11 were allowed to react with the phosphorane 7 and the iminophosphorane 9, respectively. Some of these new organophosphorus compounds are found to have insecticidal and molluscicidal properties against cotton leafworm Spodoptera littoralis larvae and Biomphalaria alexandrina snails. © 1997 John Wiley, & Sons, Inc.
    Additional Material: 2 Tab.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Colorimetric evaluation of thermooxidative degradation of nylon 6 fibers (1995)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 57 (1995), S. 265-270 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Nylon 6 fibers were annealed in air at 160°C for periods ranging from 1 to 10 h. Their spectral reflectance values were measured. Color parameters, including luminance factor, dominant wavelength, purity, and the color difference between annealed nylon 6 fiber samples and unheated ones were calculated. The observed variations in the colors of samples were assumed due to the thermal and oxidation degradations. The behavior of the color parameters with heating duration was compared with the general kinetic curve of thermooxidative degradation of polymers and the match between them is discussed. The color difference ΔE values is recommended for monitoring the thermooxidative degradation of nylon 6 fibers. © 1995 John Wiley & Sons, Inc.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1995.070570303
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  • 7
    Electronic Resource
    Electronic Resource
    Synthesen und Strukturen von Aluminium-Fluor-Sauerstoff-ClusternProfessor Heribert Offermanns zum 60. Geburtstag gewidmetDiese Arbeit wurde von der Deutschen Forschungsgemeinschaft gefördert. (1997)
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 109 (1997), S. 2738-2739 
    Details
    ISSN: 0044-8249
    Keywords: Aluminium ; Cluster ; Fluor ; O-Liganden ; Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ange.19971092318
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  • 8
    Electronic Resource
    Electronic Resource
    Distance indices in a comparison between the A, D, I and R genomes of the Triticeae tribe (1995)
    Weinheim : Wiley-Blackwell
    Electrophoresis 16 (1995), S. 1295-1300 
    Details
    ISSN: 0173-0835
    Keywords: Triticum ; Secale ; Hordeum ; Two-dimensional polyacrylamide gel electrophoresis ; Phylogenetic relationships ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Two-dimensional gel electrophoresis of shoot proteins was used to study the relationships between Triticum, Secal, and Hordeum. A high level of polymorphism was found among the 1275 spots scored: only 198 spots were found common to all. But, under the hypothesis that only allelic variations were observed, the mean number of alleles per locus was only two. Phenograms were built from different distance indices. All of them showed Triticum genomes A and D close to each other, Hordeum, far from the Triticum cluster, and Secale at an intermediate position. A discussion on the use of various distance indices is presented.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/elps.11501601212
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  • 9
    Electronic Resource
    Electronic Resource
    Synthesis and Structure of Aluminum-Fluorine-Oxygen ClustersThis work was supported by the Deutsche Forschungsgemeinschaft.Dedicated to Professor Heribert Offermanns on the occasion of his 60th birthday (1997)
    Weinheim : Wiley-Blackwell
    Angewandte Chemie International Edition in English 36 (1997), S. 2625-2626 
    Details
    ISSN: 0570-0833
    Keywords: aluminum ; clusters ; fluorine ; O ligands ; Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/anie.199726251
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