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  • 1
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    Activation of the myogenic lineage by MEF2A, a factor that induces and cooperates with MyoD (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-11-18
    Description: Muscle enhancer factor-2A (MEF2A), a member of the MADS family, induced myogenic development when ectopically expressed in clones of nonmuscle cells of human clones, a function previously limited to the muscle basic helix-loop-helix (bHLH) proteins. During myogenesis, MEF2A and bHLH proteins cooperatively activate skeletal muscle genes and physically interact through the MADS domain of MEF2A and the three myogenic amino acids of the muscle bHLH proteins. Thus, skeletal myogenesis is mediated by two distinct families of mutually inducible and interactive muscle transcription factors, either of which can initiate the developmental cascade.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaushal, S -- Schneider, J W -- Nadal-Ginard, B -- Mahdavi, V -- New York, N.Y. -- Science. 1994 Nov 18;266(5188):1236-40.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cardiology, Children's Hospital, Harvard Medical School, Boston, MA 02115.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7973707" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Binding Sites ; Cell Differentiation ; Cell Line ; DNA/metabolism ; DNA-Binding Proteins/genetics/*metabolism ; *Gene Expression Regulation ; Genes, Reporter ; Haplorhini ; Helix-Loop-Helix Motifs ; Humans ; MADS Domain Proteins ; MEF2 Transcription Factors ; Mice ; Molecular Sequence Data ; Muscle, Skeletal/*cytology/metabolism ; MyoD Protein/biosynthesis/*metabolism ; Myogenic Regulatory Factors ; Myogenin/biosynthesis/genetics/metabolism ; Transcription Factors/genetics/*metabolism ; Transfection
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Reversal of terminal differentiation mediated by p107 in Rb-/- muscle cells (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-06-03
    Description: The terminal differentiation of mammalian muscle cells requires the tumor suppressor retinoblastoma protein (Rb). Unlike their wild-type counterparts, multinucleated myotubes from mouse cells deficient in Rb (Rb-/-) were induced by serum to re-enter the cell cycle. Development of the myogenic phenotype in Rb-/- cells correlated with increased expression of p107, which interacted with myogenic transcription factors. Serum-induced cell cycle reentry, on the other hand, correlated with decreased p107 expression. Thus, although p107 could substitute for Rb as a cofactor for differentiation, it could not maintain the terminally differentiated state in Rb-/- myotubes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schneider, J W -- Gu, W -- Zhu, L -- Mahdavi, V -- Nadal-Ginard, B -- New York, N.Y. -- Science. 1994 Jun 3;264(5164):1467-71.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cardiology, Children's Hospital, Harvard Medical School, Boston, MA 02115.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8197461" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blood ; Cell Cycle ; Cell Differentiation ; Cell Line ; Culture Media ; Gene Expression ; Helix-Loop-Helix Motifs ; Humans ; Mice ; Muscles/*cytology/metabolism ; Myogenin/metabolism ; *Nuclear Proteins ; Proteins/genetics/*physiology ; Recombinant Fusion Proteins/metabolism ; Retinoblastoma Protein/genetics/*physiology ; Retinoblastoma-Like Protein p107 ; Transcriptional Activation ; Transfection ; Tumor Cells, Cultured
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    The HST Quasar Absorption-Line Key Project. 8: CCD imaging of Hubble Space Telescope quasar fields (1994)
    In:  Other Sources
    Details
    Publication Date: 2019-07-13
    Description: We present an analysis of CCD images of more than 100 quasars; many of the objects have been or will be observed in the Hubble Space Telescope (HST) Key Project Quasar Absorption-Line Survey. The data set consists of B, g, and i photometry of 117 quasars and deeper g (limiting magnitude of approximately equal 22) images of 101 quasar fields. Positions accurate to approximately equal 1 sec, measured with the Space Telescope Science Institute's Astrometric Support Program, are listed for all of the quasars in this study. Positions, magnitudes, and classifications of stars and galaxies located within approximately equal 100 sec of the quasars are given for all of the deep g data. The positions of the stars and galaxies relative to the quasar are accurate to approximately equal 0.5 sec. The results presented here can be used to prepare spectroscopic programs designed to obtain redshifts of galaxies in the fields of these quasars.
    Keywords: ASTROPHYSICS
    Type: Astronomical Society of the Pacific, Publications (ISSN 0004-6280); 106; 700; p. 646-669
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  • 4
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    The ultraviolet emission properties of five low-redshift active galactic nuclei at high signal-to-noise ratio and spectral resolution (1994)
    In:  Other Sources
    Details
    Publication Date: 2019-08-28
    Description: We analyze the ultraviolet (UV) emission line and continuum properties of five low-redshift active galactic nuclei (four luminous quasars: PKS 0405-123, H1821 + 643, PG 0953 + 414, and 3C 273, and one bright Seyfert 1 galaxy: Mrk 205). The HST spectra have higher signal-to-noise ratios (typically approximately 60 per resolution element) and spectral resolution (R = 1300) than all previously published UV spectra used to study the emission characteristics of active galactic nuclei. We include in the analysis ground-based optical spectra covering H beta and the narrow (O III) lambda lambda 4959, 5007 doublet. New results are obtained and presented.
    Keywords: ASTROPHYSICS
    Type: Astrophysical Journal, Part 1 (ISSN 0004-637X); 420; 1; p. 110-135
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  • 5
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    The HST quasar absorption line key project. 9: An emission-line study of PG 2251+113 (1994)
    In:  Other Sources
    Details
    Publication Date: 2019-07-13
    Description: We present Hubble Space Telescope (HST) and quasi-simultaneous ground-based observations of the z = 0.3252 QSO PG 2251+113. We find a correlation between line widths and the critical density for de-excitation of the forbidden emission lines observed in this object. We can show that this correlation also applies to the semiforbidden and possibly also the permitted lines which arise in the broad emission-line region. While this result was predicted from statistical studies, it has never previously been shown to hold in detail in any individual object. This relationship between the narrow and broad emission-line regions may help constrain dynamical models of both regions. We examine the implications of this result for a simple radial infall model of the emitting gas developed to explain the origin of narrow-line profiles.
    Keywords: ASTROPHYSICS
    Type: Astrophysical Journal, Part 1 (ISSN 0004-637X); 434; 2; p. 484-492
    Format: text
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