ISSN:
1573-4919
Keywords:
aluminium
;
monoamine oxidase
;
kynuramine
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Chemistry and Pharmacology
,
Medicine
Notes:
Abstract Effect of aluminium (Al) on rat brain mitochondrial monoamine oxidase-A (MAO-A) was studiedin vitro at three different pH (4.0, 7.4 and 9.0) values. The results have shown that Al is a non-competitive inhibitor for MAO-A. The data also showed that MAO-A inhibition by Al varies with free Al3+ concentration and different forms of Al under different pH conditions. Al altered the maximum velocity (Vmax) of MAO-A but did not affect substrate-enzyme affinity (Km). Al formed a strong chelation with the substrate (Kynuramine) (1:1).
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00926039
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