ISSN:
1573-4927
Keywords:
Neurospora
;
glutamine synthetase
;
glutamate dehydrogenase
;
glutamate synthase
;
regulation
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Chemistry and Pharmacology
Notes:
Abstract InNeurospora crassa thenit-2 andnmr-1 (ms-5) loci represent the major control genes encoding regulatory proteins that allow the coordinated expression of various systems involved with the utilization of a secondary nitrogen source. In this paper we examine the effect of thenit-2 andms-5 (nmr-1 locus) mutations on the regulation of the ammonium assimilation enzymes, glutamine synthetase and glutamate dehydrogenase, which are regulated by the products of these genes; however, glutamate synthase is not so regulated. Glutamine synthetase and glutamate dehydrogenase levels are also regulated by the amino nitrogen content. We present evidence that thems-5 andgln r strains, which behave very similarly in their resistance to glutamine repression, are different and map in different loci.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00553459
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