Publication Date:
1993-10-15
Description:
Although many T cells carry two in-frame V alpha rearrangements, the products of both V alpha rearrangements have never been shown simultaneously on the surface of normal cells. With the use of monoclonal antibodies to V alpha 2, V alpha 12, and V alpha 24, up to one-third of mature T cells expressed two V alpha chains as part of two functional and independent T cell receptors (TCRs). Thus, the "one cell, one receptor" rule does not apply to a large subset of alpha beta T cells. Cells that belong to this dual TCR subset may be specific for a broader range of antigens than cells with a single receptor, which may be important for autoimmunity and alloreactivity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Padovan, E -- Casorati, G -- Dellabona, P -- Meyer, S -- Brockhaus, M -- Lanzavecchia, A -- New York, N.Y. -- Science. 1993 Oct 15;262(5132):422-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Basel Institute for Immunology, Switzerland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8211163" target="_blank"〉PubMed〈/a〉
Keywords:
Antibodies, Monoclonal
;
Antigens, CD3/analysis
;
Base Sequence
;
Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor
;
Humans
;
Molecular Sequence Data
;
Receptors, Antigen, T-Cell, alpha-beta/*analysis/genetics/immunology
;
T-Lymphocytes/*immunology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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