Publikationsdatum:
1993-08-27
Beschreibung:
Plasmodium vivax and P. falciparum are the major causes of human malaria, except in sub-Saharan Africa where people lack the Duffy blood group antigen, the erythrocyte receptor for P. vivax. Duffy negative human erythrocytes are resistant to invasion by P. vivax and the related monkey malaria, P. knowlesi. Several lines of evidence in the present study indicate that the Duffy blood group antigen is the erythrocyte receptor for the chemokines interleukin-8 (IL-8) and melanoma growth stimulatory activity (MGSA). First, IL-8 binds minimally to Duffy negative erythrocytes. Second, a monoclonal antibody to the Duffy blood group antigen blocked binding of IL-8 and other chemokines to Duffy positive erythrocytes. Third, both MGSA and IL-8 blocked the binding of the parasite ligand and the invasion of human erythrocytes by P. knowlesi, suggesting the possibility of receptor blockade for anti-malarial therapy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Horuk, R -- Chitnis, C E -- Darbonne, W C -- Colby, T J -- Rybicki, A -- Hadley, T J -- Miller, L H -- HL 41382/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1993 Aug 27;261(5125):1182-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Genentech, Inc., South San Francisco, CA 94080.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7689250" target="_blank"〉PubMed〈/a〉
Schlagwort(e):
Animals
;
*Antigens, Protozoan
;
Chemokine CCL5
;
Chemokine CXCL1
;
*Chemokines, CXC
;
Chemotactic Factors/metabolism
;
Cytokines/metabolism
;
*Duffy Blood-Group System
;
Erythrocytes/*parasitology
;
Growth Substances/metabolism
;
Humans
;
*Intercellular Signaling Peptides and Proteins
;
Interleukin-8/*metabolism
;
Lymphokines/metabolism
;
Monocyte Chemoattractant Proteins
;
Plasmodium knowlesi/*metabolism/physiology
;
Plasmodium vivax/*metabolism/physiology
;
*Protozoan Proteins
;
Receptors, Cell Surface/*metabolism
;
Receptors, Immunologic/*metabolism
;
Receptors, Interleukin-8A
Print ISSN:
0036-8075
Digitale ISSN:
1095-9203
Thema:
Biologie
,
Chemie und Pharmazie
,
Informatik
,
Medizin
,
Allgemeine Naturwissenschaft
,
Physik
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