Publication Date:
1993-11-05
Description:
A mysterious respiratory illness with high mortality was recently reported in the southwestern United States. Serologic studies implicated the hantaviruses, rodent-borne RNA viruses usually associated elsewhere in the world with hemorrhagic fever with renal syndrome. A genetic detection assay amplified hantavirus-specific DNA fragments from RNA extracted from the tissues of patients and deer mice (Peromyscus maniculatus) caught at or near patient residences. Nucleotide sequence analysis revealed the associated virus to be a new hantavirus and provided a direct genetic link between infection in patients and rodents.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nichol, S T -- Spiropoulou, C F -- Morzunov, S -- Rollin, P E -- Ksiazek, T G -- Feldmann, H -- Sanchez, A -- Childs, J -- Zaki, S -- Peters, C J -- New York, N.Y. -- Science. 1993 Nov 5;262(5135):914-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8235615" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Base Sequence
;
Bunyaviridae Infections/epidemiology/*microbiology/veterinary
;
DNA Primers
;
*Disease Outbreaks
;
*Disease Reservoirs
;
*Genome, Viral
;
Hantavirus/classification/*genetics/isolation & purification
;
Humans
;
Lung Diseases/epidemiology/*microbiology
;
Molecular Sequence Data
;
Peromyscus/*microbiology
;
Phylogeny
;
Polymerase Chain Reaction
;
Rodent Diseases/epidemiology/microbiology
;
Sequence Homology, Nucleic Acid
;
Southwestern United States/epidemiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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