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  • Polymer and Materials Science  (2)
  • Hepsulfam  (1)
  • 1990-1994  (3)
  • 1991  (3)
  • 1
    ISSN: 1573-0646
    Keywords: Fostriecin ; Hepsulfam ; PZDT ; hematopoietic progenitors ; human ; murine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The in vitro myelotoxic potentials of three investigational antitumor agents, Fostriecin, Hepsulfam and pyrazine diazohydroxide (PZDH), were evaluated utilizing clonogenic assays. Human and murine marrow cells were exposed to each drug for 1 hr prior to culture in microcapillary (human) or Petri dish (murine) assays. Fostriecin (0.22–220 μM), Hepsulfam (0.34–340 μM) and PZDH (0.68–680 μM) inhibited myeloid (CFU-gm), erythroid (BFU-e, CFU-e) and megakaryocytic (CFU-meg) colony formation in a concentration-dependent manner. CFU-e from both species were more sensitive to Fostriecin than the other progenitors and murine cells more sensitive overall to Fostriecin than their human counterparts. Murine CFU-e were also more sensitive to Hepsulfam than human CFU-e, with CFU-gm and BFU-e being similarly affected in both species. Human BFU-e were greatly inhibited by PZDH, whereas murine BFU-e were relatively resistant to its toxic effects. Fostriecin was the most toxic of the three antitumor agents, with PZDH the least toxic.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    New York : Wiley-Blackwell
    Die Makromolekulare Chemie 192 (1991), S. 1399-1408 
    ISSN: 0025-116X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Fluorescence emission of amorphous poly(ethylene terephthalate) films at wavelengths larger than that of the excimer emission was investigated. A film thickness dependence of the excitation spectra for 360 nm emission was observed. For thick films (e.g., 280 μm), their excitation spectra for 380-460 nm emission showed excitation peaks in the region of 320-360 nm, and the intensity ratio of the 370 nm emission (excited by 290 nm radiation) to the 390 nm emission (excited by 340 nm radiation) decreased with increasing thickness of the film. Apparently, the 370 nm emission (excimer) and the 380-460 nm emission originate from different species of the excited state. From the studies of model systems, dilute solutions of dimethyl terephthalate in CHCl3-acetone and dimethyl terephthalate-PMMA in CHCl3, it was found that the excitation at 340 nm is related to a \documentclass{article}\pagestyle{empty}\begin{document}$ \mathop \pi \limits^* $\end{document} ← n transition. Fluorescence emission from the S1 (n-\documentclass{article}\pagestyle{empty}\begin{document}$ \mathop \pi \limits^* $\end{document}) state and the interaction between the C=O group and the phenylene π-electrons results in the fluorescence in the 380-460 nm region.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 43 (1991), S. 1323-1326 
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: We have investigated the effects of 1,3-bis (methylphenylethynylvinyl) disiloxane (BMPVDS) as crosslinker on heat-curable silicone rubber and measured sol fractions and crosslink density of vulcanizates by benzene-extract and toluene-swelling methods, respectively. The experimental results show that, adding suitable amounts of BMPVDS, the vulcanizates exhibited rather fine mechanical properties. The tear strength of some vulcanizates could reach as high as 60.31 kN/m, the tensile strength 13.46 MPa, and the modulus at 100% extension 2.45 MPa, and the permanent deformation is rather low. BMPVDS is also a good curing retarder of hydrosilation curing silicone rubber. When adding 0.08 part of BMPVDS or more, the stocks can store at 20 ± 1°C more than 50 days without curing.
    Additional Material: 4 Tab.
    Type of Medium: Electronic Resource
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