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  • O6-methylguanine-DNA methyltransferase  (2)
  • Engineering  (1)
  • Springer  (2)
  • Wiley-Blackwell  (1)
  • Institute of Physics
  • Wiley
  • 2000-2004
  • 1990-1994  (3)
  • 1991  (3)
Collection
Keywords
Publisher
  • Springer  (2)
  • Wiley-Blackwell  (1)
  • Institute of Physics
  • Wiley
Years
  • 2000-2004
  • 1990-1994  (3)
Year
  • 1991  (3)
  • 1
    Electronic Resource
    Electronic Resource
    Normal expression of thymidine kinase and O6-methylguanine-DNA methyltransferase in cultured fibroblasts from individuals with hereditary galactokinase deficiency (1991)
    Springer
    Biochemical genetics 29 (1991), S. 135-144 
    Details
    ISSN: 1573-4927
    Keywords: galactokinase ; thymidine kinase ; O6-methylguanine-DNA methyltransferase ; gene regulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Expression of the enzymes galactokinase, thymidine kinase, and O6-methylguanine-DNA methyltransferase is occasionally coordinately regulated in human cell lines. We have measured the activities of these three enzymes in extracts of fibroblasts from individuals with hereditary galactokinase deficiency. These cells do not express measurable galactokinase activity. The levels of O6-methylguanine-DNA methyltransferase were in the normal range in cells from three galactokinase-deficient individuals. The activity of thymidine kinase in the affected cells was in the normal range for two of the three individuals. The reduced thymidine kinase activity in the third individual reflected the extremely poor growth of the cells in culture. Immortalization of one galactokinase-deficient cell line resulted in loss of O6-methylguanine-DNA methyltransferase activity, but the galactokinase and thymidine kinase levels remained unchanged. The data indicate that the loss of galactokinase activity in these individuals is the consequence of an alteration of gene expression which does not involve coordinate silencing with the thymidine kinase and methyltransferase loci.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00554207
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Normal expression of thymidine kinase and O6-methylguanine-DNA methyltransferase in cultured fibroblasts from individuals with hereditary galactokinase deficiency (1991)
    Springer
    Biochemical genetics 29 (1991), S. 135-144 
    Details
    ISSN: 1573-4927
    Keywords: galactokinase ; thymidine kinase ; O6-methylguanine-DNA methyltransferase ; gene regulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Expression of the enzymes galactokinase, thymidine kinase, and O6-methylguanine-DNA methyltransferase is occasionally coordinately regulated in human cell lines. We have measured the activities of these three enzymes in extracts of fibroblasts from individuals with hereditary galactokinase deficiency. These cells do not express measurable galactokinase activity. The levels of O6-methylguanine-DNA methyltransferase were in the normal range in cells from three galactokinase-deficient individuals. The activity of thymidine kinase in the affected cells was in the normal range for two of the three individuals. The reduced thymidine kinase activity in the third individual reflected the extremely poor growth of the cells in culture. Immortalization of one galactokinase-deficient cell line resulted in loss of O6-methylguanine-DNA methyltransferase activity, but the galactokinase and thymidine kinase levels remained unchanged. The data indicate that the loss of galactokinase activity in these individuals is the consequence of an alteration of gene expression which does not involve coordinate silencing with the thymidine kinase and methyltransferase loci.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02401808
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Paving: A new approach to automated quadrilateral mesh generation (1991)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 32 (1991), S. 811-847 
    Details
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: This paper presents a new mesh generation technique, paving, which meshes arbitrary 2-D geometries with an all-quadrilateral mesh. Paving allows varying element size distributions on the boundary as well as the interior of a region. The generated mesh is well formed (i.e. nearly square elements, elements perpendicular to boundaries, etc.) and geometrically pleasing (i.e. mesh contours tend to follow geometric contours of the boundary). In this paper we describe the theory behind this algorithmic/heuristic technique, evaluate the performance of the approach and present examples of automatically generated meshes.
    Additional Material: 42 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/nme.1620320410
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