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  • LUNAR AND PLANETARY EXPLORATION  (6)
  • Molecular Sequence Data  (3)
  • 2020-2022
  • 2005-2009
  • 1990-1994  (9)
  • 1990  (9)
  • 1
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    Expression of T cell antigen receptor heterodimers in a lipid-linked form (1990)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1990-08-10
    Description: The interaction of the T cell receptor for antigen (TCR) with its antigen-major histocompatibility complex ligand is difficult to study because both are cell surface multimers. The TCR consists of two chains (alpha and beta) that are complexed to the five or more nonpolymorphic CD3 polypeptides. A soluble form of the TCR was engineered by replacing the carboxyl termini of alpha and beta with signal sequences from lipid-linked proteins, making them susceptible to enzymatic cleavage. In this manner, TCR heterodimers can be expressed independently of the CD3 polypeptides and in significant quantities (0.5 milligram per week). This technique seems generalizable to biochemical and structural studies of many other cell surface molecules as well.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lin, A Y -- Devaux, B -- Green, A -- Sagerstrom, C -- Elliott, J F -- Davis, M M -- New York, N.Y. -- Science. 1990 Aug 10;249(4969):677-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, Stanford University School of Medicine, CA 94305-5402.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1696397" target="_blank"〉PubMed〈/a〉
    Keywords: Alkaline Phosphatase/genetics ; Amino Acid Sequence ; Animals ; Antigens, CD3 ; Antigens, CD55 ; Antigens, Differentiation, T-Lymphocyte/genetics ; Cell Line ; Complement Inactivator Proteins/genetics ; Female ; Humans ; Macromolecular Substances ; Membrane Proteins/genetics ; Molecular Sequence Data ; Placenta/enzymology ; Pregnancy ; Protein Sorting Signals/genetics ; Receptors, Antigen, T-Cell/*genetics ; Transfection
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Translation initiation and ribosomal biogenesis: involvement of a putative rRNA helicase and RPL46 (1990)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1990-03-02
    Description: Cold-sensitive mutations in the SPB genes (spb1-spb7) of Saccharomyces cerevisiae suppress the inhibition of translation initiation resulting from deletion of the poly(A)-binding protein gene (PAB1). The SPB4 protein belongs to a family of adenosine triphosphate (ATP)-dependent RNA helicases. The aberrant production of 25S ribosomal RNA (rRNA) occurring in spb4-1 mutants or the deletion of SPB2 (RPL46) permits the deletion of PAB1. These data suggest that mutations affecting different steps of 60S subunit formation can allow PAB-independent translation, and they indicate that further characterization of the spb mutations could lend insight into the biogenesis of the ribosome.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sachs, A B -- Davis, R W -- R37 GM 21891/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1990 Mar 2;247(4946):1077-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry, Stanford Medical Center, CA 94305.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2408148" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Base Sequence ; Carrier Proteins/genetics/metabolism ; DEAD-box RNA Helicases ; Molecular Sequence Data ; Mutation ; Poly(A)-Binding Proteins ; *Protein Biosynthesis ; RNA Nucleotidyltransferases/genetics/*metabolism ; RNA Processing, Post-Transcriptional ; RNA, Fungal/genetics/metabolism ; RNA, Ribosomal/genetics/*metabolism ; Ribosomal Proteins/genetics/*metabolism ; Ribosomes/*metabolism ; Saccharomyces cerevisiae/enzymology/*genetics ; *Saccharomyces cerevisiae Proteins ; Sequence Homology, Nucleic Acid
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    A receptor for tumor necrosis factor defines an unusual family of cellular and viral proteins (1990)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1990-05-25
    Description: Tumor necrosis factor alpha and beta (TNF-alpha and TNF-beta) bind surface receptors on a variety of cell types to mediate a wide range of immunological responses, inflammatory reactions, and anti-tumor effects. A cDNA clone encoding an integral membrane protein of 461 amino acids was isolated from a human lung fibroblast library by direct expression screening with radiolabeled TNF-alpha. The encoded receptor was also able to bind TNF-beta. The predicted cysteine-rich extracellular domain has extensive sequence similarity with five proteins, including nerve growth factor receptor and a transcriptionally active open reading frame from Shope fibroma virus, and thus defines a family of receptors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, C A -- Davis, T -- Anderson, D -- Solam, L -- Beckmann, M P -- Jerzy, R -- Dower, S K -- Cosman, D -- Goodwin, R G -- New York, N.Y. -- Science. 1990 May 25;248(4958):1019-23.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Immunex Corporation, Seattle, WA 98101.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2160731" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Blotting, Northern ; Cloning, Molecular ; DNA/genetics ; Humans ; Membrane Proteins/genetics ; Molecular Sequence Data ; Multigene Family ; Receptors, Cell Surface/*genetics ; Receptors, Tumor Necrosis Factor ; Tumor Necrosis Factor-alpha/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    A model of Saturn's magnetic field based on all available data (1990)
    In:  Other Sources
    Details
    Publication Date: 2011-08-19
    Description: A model of Saturn's magnetic field, called Saturn Pioneer Voyager (SPV), is developed on the basis of an analysis of three sets of data: those from the Pioneer 11, the Voyager 1, and the Voyager 2 magnetometers. It is shown that the SPV model fits the data observed between 1.3 and 8.0 Saturn radii from the planet's center with a 1.13 percent weighted rms average of the percent differences between the observed and modeled fields, which is substantially better than the fits yielded by any of the previous models.
    Keywords: LUNAR AND PLANETARY EXPLORATION
    Type: Journal of Geophysical Research (ISSN 0148-0227); 95; 15257-15
    Format: text
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  • 5
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    Discontinuities in the shallow Martian crust at Lunae, Syria, and Sinai Plana (1990)
    In:  Other Sources
    Details
    Publication Date: 2011-08-19
    Description: Detailed photoclinometric data are presented for a variety of surface features (pits, troughs, wall valleys, and grabens) within three study areas in the western equatorial regions of Mars (Lunae, Syria, and Sinai Plana) that provide evidence for mechanical discontinuities within the shallow Martian crust in these regions. The data's relation to some of the previously proposed mechanical discontinuities within the Martian crust is discussed, and the geologic significance of these features is speculated upon.
    Keywords: LUNAR AND PLANETARY EXPLORATION
    Type: Journal of Geophysical Research (ISSN 0148-0227); 95; 14231-14
    Format: text
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  • 6
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    Isotope mass fractionation during evaporation of Mg2SiO4 (1990)
    In:  Other Sources
    Details
    Publication Date: 2011-08-19
    Description: Synthetic forsterite (Mg2SiO4) was partially evaporated in vacuum for various durations and at different temperatures. The residual charges obtained when molten Mg2SiO4 was evaporated to 12 percent of its initial mass were enriched in heavy isotopes by about 20, 30, and 15 per mil/amu for O, Mg, and Si, respectively, whereas solid forsterite evaporated to a similar residual mass fraction showed negligible fractionations. These results imply that calcium and aluminum-rich refractory inclusions in carbonaceous chondrites must have been at least partially molten in the primordial solar nebula if the observed large mass fractionation effects were caused by evaporation processes in the nebula.
    Keywords: LUNAR AND PLANETARY EXPLORATION
    Type: Nature (ISSN 0028-0836); 347; 655-658
    Format: text
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  • 7
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    Specification goals for a Mars seismic network (1990)
    In:  CASI
    Details
    Publication Date: 2013-08-31
    Description: A seismic network on Mars should have enough stations (e.g., 24) to characterize the seismicity of the planet for comparison with a diversity of structural features; be comprised of low noise stations, preferably underground, 3 to 4 orders of magnitude more sensitive than those used on Viking; record over a sufficient band-width (DC-30 Hz) to detect micro-earthquakes to normal modes; and record for a sufficient duration (10 years) and data rate (10(exp 8) Mb/day/station) to obtain a data set comparable to that from the Apollo mission to the Moon so that locations of major internal boundaries can be inferred, such as those in the Earth, i.e., crust - lithosphere - asthenosphere - upper - lower phase transitions - outer - inner core. The proposed Mars Global Network Mission provides an opportunity to sense the dynamics and probe the interior of the planet. The seismic objectives, the availability of the instrumentation and trade-offs to meet them are discussed.
    Keywords: LUNAR AND PLANETARY EXPLORATION
    Type: JPL, Proceedings of the Mars Global Network Mission Workshop; p 159-173
    Format: application/pdf
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  • 8
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    Photometric geodesy of main-belt asteroids. III - Additional lightcurves (1990)
    In:  Other Sources
    Details
    Publication Date: 2019-07-12
    Description: A total of 107 complete or partial lightcurves are presented for 59 different asteroids over the 1982-1989 period. Unusual lightcurves with unequal minima and maxima at large amplitudes are preferentially seen for M-type asteroids. Some asteroids, such as 16 Psyche and 201 Penelope, exhibit lightcurves combining large amplitude with very unequal brightness for both maxima and both minima, even at small phase angles. An M-type asteroid is believed to consist of a metal core of a differentiated parent body that has had its rocky mantle completely removed by one or more large impacts.
    Keywords: LUNAR AND PLANETARY EXPLORATION
    Type: Icarus (ISSN 0019-1035); 86; 402-447
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  • 9
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    On collisional disruption - Experimental results and scaling laws (1990)
    In:  Other Sources
    Details
    Publication Date: 2019-07-12
    Description: Both homogeneous and inhomogeneous targets have been addressed by the present experimental consideration of the impact strengths, fragment sizes, and fragment velocities generated by cement mortar targets whose crushing strengths vary by an order of magnitude, upon impact of projectiles in the velocity range of 50-5700 m/sec. When combined with additional published data, dynamic impact strength is found to correlate with quasi-static material strengths for materials ranging in character from basalt to ice; two materials not following this trend, however, are weak mortar and clay targets. Values consistent with experimental results are obtainable with a simple scaling algorithm based on impact energy, material properties, and collisional strain rate.
    Keywords: LUNAR AND PLANETARY EXPLORATION
    Type: Icarus (ISSN 0019-1035); 83; 156-182
    Format: text
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