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  • ASTROPHYSICS  (472)
  • Life and Medical Sciences  (215)
  • 1990-1994  (687)
  • 1980-1984
  • 1970-1974
  • 1940-1944
  • 1993  (385)
  • 1990  (302)
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  • 1990-1994  (687)
  • 1980-1984
  • 1970-1974
  • 1940-1944
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  • 1
    Electronic Resource
    Electronic Resource
    Microscopy in solid state science (1993)
    New York, NY [u.a.] : Wiley-Blackwell
    Microscopy Research and Technique 24 (1993), S. 299-315 
    Details
    ISSN: 1059-910X
    Keywords: STEM ; PEELS ; HAADFI ; Nanolithography ; Super-resolution ; STM ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Natural Sciences in General
    Notes: The Microstructural Physics group at the Cavendish Laboratory is actively involved in a considerable number of research projects which cover a broad range of materials science. In this paper, we describe briefly several such projects, with particular emphasis given to the application of parallel-detection electron energy loss spectroscopy (PEELS) on a scanning transmission electron microscope (STEM) to the analysis of materials such as stainless steels, catalysts, and high temperature superconductors. In addition, we describe a number of related projects that are currently being carried out in the group, particularly those which utilise and develop novel STEM imaging and analytical techniques. © 1993 Wiley-Liss, Inc.
    Additional Material: 19 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jemt.1070240404
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Dibutyryl cyclic adenosine monophosphate differentially regulates cell proliferation in low and high alkaline phosphatase SaOS-2 human osteosarcoma cells: Evidence for mediation by the insulin-like growth factor-II system (1993)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 156 (1993), S. 462-468 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: In the present study, we have sought to determine whether a given signal transduction pathway can have diverse effects on subpopulations of cells of a lineage depending upon the stage of differentiation. To test this hypothesis, we selected the cyclic adenosine monophosphate (cAMP) signal transduction pathway because of its recognized importance in mediating the actions of many hormones, e.g., parathyroid hormone which acts on the bone-forming cells, the osteoblasts. Subpopulations of human osteosarcoma SaOS-2 cells with low (LSaOS) and high (HSaOS) alkaline phosphatase (ALP) content were chosen as model systems for preosteoblasts (pre-OB) and osteoblasts (OB), respectively. Dibutyryl cyclic AMP (DBcAMP) treatment of serum free cultures produced a differential effect on the proliferation of LSaOS cells (40 ± 5% of control at 1 mM DBcAMP, P 〈 0.001) compared with HSaOS cells (no statistically significant effect). The finding supports the hypothesis. Next, we sought evidence for mediation, at least in part, by the insulin-like growth factor (IGF)-II regulatory system. We report that the basal expression of IGF-II, IGF binding protein (IGFBP)-3, and IGFBP-4 was higher in LSaOS cells than in HSaOS cells with the opposite true for type I IGF receptor. DBcAMP treatment of LSaOS cells decreased IGF-II and IGFBP-3 but increased IGFBP-4 and type I IGF receptor; no effect was observed for the type II IGF receptors. DBcAMP treatment of HSaOS cells had no detectable effect on IGF-II; IGFBP-3, or type I and type II IGF receptor expression; only IGFBP-4 expression increased with DBcAMP. These observations suggest that the differential regulation of cell proliferation by the cAMP signal transduction pathway may be mediated, at least in part, by the IGF-II regulatory system. © 1993 Wiley-Liss, Inc.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1041560305
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  • 3
    Electronic Resource
    Electronic Resource
    A simple model for calculating residential 60-Hz magnetic fields (1990)
    New York, NY [u.a.] : Wiley-Blackwell
    Bioelectromagnetics 11 (1990), S. 283-296 
    Details
    ISSN: 0197-8462
    Keywords: grounding currents ; ELF ; exposure assessment ; Life and Medical Sciences ; Occupational Health and Environmental Toxicology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Physics
    Notes: A model is presented that permits the calculation of densities of 60-Hz magnetic fields throughout a residence from only a few measurements. We assume that residential magnetic fields are produced by sources external to the house and by the residential grounding circuit. The field from external sources is measured with a single probe. The field produced by the grounding circuit is calculated from the current flowing in the circuit and its geometry. The two fields are combined to give a prediction of the total field at any point in the house. A data-acquisition system was built to record the magnitude and phase of the grounding current and the field from external sources. The model's predictions were compared with measurements of the total magnetic field at a single location in 23 houses; a correlation coefficient of .87 was obtained, indicating that the model has good predictive capability. A more detailed study that was carried out in one house permitted comparisons of measurements with the model's predictions at locations throughout the house. Again, quite reasonable agreement was found. We also investigated the temporal variability of field readings in this house. Daily magnetic field averages were found to be considerably more stable than hourly averages. Finally, we demonstrate the use of the model in creating a profile of the magnetic fields in a home.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bem.2250110405
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  • 4
    Electronic Resource
    Electronic Resource
    Problems and paradigms: Altering sex ratios: The games microbes play (1993)
    New York, NY : Wiley-Blackwell
    BioEssays 15 (1993), S. 695-697 
    Details
    ISSN: 0265-9247
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: The male gametes of most organisms lack cytoplasm. Consequently, most cytoplasmic genetic elements are maternally inherited: they cannot be transmitted patrilinnearly. The evolutionary interests of cytoplasmic elements therefore lie in transmission through the female. These elements may thus be in evolutionary conflict with nuclear genes which are transmitted by both sexes. This conflict is manifested in observations of cytoplasmically induced biased sex-ratios. Some cytoplasmic genes avoid this fate by biasing the primary sex ratio towards females, or by inducing parthenogenesis. Others kill male hosts, and either achieve transmission via dispersal, or benefit their clonal relatives in the dead male's female siblings. Still others cause the failure of zygotes resulting from pairings between males carrying specific microbes and females lacking them, causing an increase in the microbes through the sterilisation of non-bearing females. Many, but not all, of these ‘ultra-selfish’ microbes are closely related. Investigations of the significance of their phylogenetic affinities, or lack of them, their adaptability in terms of the methods by which they avoid, or ameliorate, the adverse effects of being in male hosts, and their importance as selective agents in the evolution of invertebrate sex determination systems, provide fertile spheres for future research.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bies.950151010
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  • 5
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    EGRET observations of active galactic nuclei - 0836 + 710, 0454 - 234, 0804 + 499, 0906 + 430, 1510-089, and 2356 + 196 (1993)
    In:  Other Sources
    Details
    Publication Date: 2019-07-13
    Description: The Energetic Gamma Ray Experiment Telescope (EGRET) on the Compton Gamma Ray Observatory observed high-energy gamma rays (50 - 2000 MeV) from quasar 0836 + 710 (z = 2.16) during observations in 1992 January, near the time of an optical fare (von Linde et al., 1993). The gamma-ray spectrum can be fitted with a power law with photon number index 2.4 +/- 0.2. EGRET identifies quasars 0454 - 234, 0804 + 499, 0906 + 430, 1510 - 089, and 2356 + 196 at a statistical significance of between 4 and 5 standard deviations.
    Keywords: ASTROPHYSICS
    Type: Astrophysical Journal, Part 2 - Letters (ISSN 0004-637X); 415; 1; p. L13-L16.
    Format: text
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  • 6
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    Overview of the first results from EGRET (1993)
    In:  Other Sources
    Details
    Publication Date: 2011-08-24
    Description: An overview of the early results of EGRET, one of four instruments carried on the Compton Gamma Ray Observatory, is presented with regard to observations of pulsars, bursts, galactic diffuse radiation, and active galaxies. The June 11, 1992 solar flare was observed in gamma rays with energies from the threshold of detection to energies over 1 GeV. Detailed time histories and energy spectra were obtained for the Crab and Vela pulsars, with one of the Vela pulses being quite sharp, approximately 2 percent of the total period. Several gamma-ray bursts were recorded. The one on May 3, 1991 was seen in EGRET's spark chamber system, which made it possible to determine a position. The quasars 3C 279, which has a redshift of 0.538, was seen in high energy gamma rays in both June and October 1992.
    Keywords: ASTROPHYSICS
    Type: Astronomy and Astrophysics Supplement Series (ISSN 0365-0138); 97; 1; p. 13-16.
    Format: text
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  • 7
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    Constraints on the cosmic rays in the Small Magellanic Cloud (1993)
    In:  Other Sources
    Details
    Publication Date: 2011-08-24
    Description: Observations of the SMC using the Energetic Gamma Ray Experimental Telescope (EGRET) on the Compton Observatory are reported. The findings yield an upper limit for gamma-ray emission above 100 MeV of 0.5 x 10 exp -7 photon/sq cm s. The expected flux if the cosmic rays (CR) are universal rather than Galactic in origin is (2.4 +/- 0.5) x 10 exp -7 photon/sq cm s, only a third of which arises from cosmic ray electron interactions. Thus, the bulk of the CR energy density is almost certainly neither metagalactic nor universal, but Galactic in origin. The results add to the evidence that the SMC is in a nonequilibrium state and indicate that the LMC is most likely in quasi-stable equilibrium, with a CR energy density near the maximum that can be contained.
    Keywords: ASTROPHYSICS
    Type: Physical Review Letters (ISSN 0031-9007); 70; 2; p. 127-129.
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  • 8
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    Elemental analyses of hypervelocity microparticle impact sites on Interplanetary Dust Experiment sensor surfaces (1993)
    In:  CASI
    Details
    Publication Date: 2013-08-31
    Description: The Interplanetary Dust Experiment (IDE) had over 450 electrically active ultra-high purity metal-oxide-silicon impact detectors located on the six primary sides of the Long Duration Exposure Facility (LDEF). Hypervelocity microparticles (approximately 0.2 to approximately 100 micron diameter) that struck the active sensors with enough energy to break down the 0.4 or 1.0 micron thick SIO2 insulator layer separating the silicon base (the negative electrode), and the 1000 A thick surface layer of aluminum (the positive electrode) caused electrical discharges that were recorded for the first year of orbit. The high purity Al-SiO2-Si substrates allowed detection of trace (ppm) amounts of hypervelocity impactor residues. After sputtering through a layer of surface contamination, secondary ion mass spectrometry (SIMS) was used to create two-dimensional elemental ion intensity maps of microparticle impact sites on the IDE sensors. The element intensities in the central craters of the impacts were corrected for relative ion yields and instrumental conditions and then normalized to silicon. The results were used to classify the particles' origins as 'manmade,' 'natural,' or 'indeterminate.' The last classification resulted from the presence of too little impactor residue, analytical interference from high background contamination, the lack of information on silicon and aluminum residues, or a combination of these circumstances. Several analytical 'blank' discharges were induced on flight sensors by pressing down on the sensor surface with a pure silicon shard. Analyses of these blank discharges showed that the discharge energy blasts away the layer of surface contamination. Only Si and Al were detected inside the discharge zones, including the central craters of these features. Thus far a total of 79 randomly selected microparticle impact sites from the six primary sides of the LDEF have been analyzed: 36 from tray C-9 (Leading (ram), or East, side), 18 from tray C-3 (Trailing (wake), or West, side), 12 from tray B-12 (North side), 4 from tray D-6 (South side), 3 from tray H-11 (Space end), and 6 from tray G-10 (Earth end). Residue from manmade debris was identified in craters on all trays. (Aluminum oxide particle residues were not detectable on the Al/Si substrates.) These results were consistent with the IDE impact record which showed highly variable long term microparticle impact flux rates on the West, Space and Earth sides of the LDEF which could not be ascribed to astronomical variability of micrometeorite density. The IDE record also showed episodic bursts of microparticle impacts on the East, North, and South sides of the satellite, denoting passage through orbital debris clouds or rings.
    Keywords: ASTROPHYSICS
    Type: NASA. Langley Research Center, LDEF: 69 Months in Space. Second Post-Retrieval Symposium, Part 2; p 677-692
    Format: application/pdf
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  • 9
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    A decade's overview of Io's volcanic activity (1993)
    In:  CASI
    Details
    Publication Date: 2013-08-31
    Description: Over the past decade some aspects of Io's volcanic activity have changed greatly, while others have essentially remained constant. This contrast has emerged from our study of multi-wavelength, infrared, observations of Io's thermal emission. From 1983 to 1992 we observed the disk integrated flux density of Io from the NASA Infrared Telescope Facility (IRTF) on Mauna Kea, Hawaii. Our spectral coverage allows us to separate out the emission components due to volcanic thermal anomalies which are warmer than the background emission caused by solar heating. Our temporal coverage allows us to resolve individual eruptions and also to obtain the disk-integrated flux density as a function of longitude (or, equivalently, orbital phase angle). Characteristics that persisted over the decade involve Loki's location and intensity of emission, the leading hemisphere emission, and the average heat flow. The variable aspects of Io over the decade include Loki's hotter area(s) and the outbursts in the leading hemisphere.
    Keywords: ASTROPHYSICS
    Type: Lunar and Planetary Inst., Twenty-Fourth Lunar and Planetary Science Conference. Part 2: G-M; p 939-940
    Format: application/pdf
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  • 10
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    Identification of cometary and asteroidal particles in stratospheric IDP collections (1993)
    In:  Other Sources
    Details
    Publication Date: 2019-01-25
    Description: He release temperature curves were determined for a specially processed set of 5 microns to 15 microns stratospheric IDP's whose masses, densities, and compositions were accurately measured. The He release temperature in combination with atmospheric entry calculations yields a most probable entry velocity for each particle and association with either an asteroidal (low velocity) or cometary (high velocity) origin. It was found that over half of the 5-15 microns IDP's have entry velocities consistent with asteroidal origin and that at least 20 percent have cometary origins. A few of the asteroidal particles are porous aggregates and it appears that there may be close material similarities among some primitive asteroids and comets. In the processing of individual 5 microns IDP's and determination of entry velocities, a few dozen microtome slices that can be used for a variety of detailed TEM, IR, and ion probe studies were preserved. These procedures provide laboratory samples that can be generically associated with asteroids and comets and are in a sense a limited sample return mission from these primitive bodies.
    Keywords: ASTROPHYSICS
    Type: Lunar and Planetary Inst., Twenty-fourth Lunar and Planetary Science Conference. Part 1: A-F; p 205-206
    Format: text
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