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  • Artikel  (27)
  • Springer  (22)
  • American Geophysical Union  (2)
  • American Society of Hematology  (2)
  • Springer Nature  (1)
  • 1985-1989  (27)
  • 1989  (27)
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  • Artikel  (27)
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  • 1985-1989  (27)
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  • 1
    Digitale Medien
    Digitale Medien
    An altered splice site is found in the DRB4 gene that is not expressed in HLA-DR7, Dw11 individuals (1989)
    Springer
    Immunogenetics 29 (1989), S. 317-322 
    Details
    ISSN: 1432-1211
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Abstract The HLA-DRβ protein, DRβIV, encoded by the DRB4 gene, is found on class II+ cells of all DR4, DR9, and most DR7 individuals. However, in some DR7 individuals (DR7, Dw11), the DRβIV protein cannot be detected. To investigate the molecular mechanism responsible for this defect in expression, two overlapping genomic clones encoding the defective DRB4 allele (DRB4-null) were isolated. Although restriction fragment length analysis demonstrated no obvious alterations in the DRB4-null gene, nucleotide sequence analysis revealed a single base substitution in the acceptor splice site at the 3′ end of the first intron, changing the normal AG dinucleotide to AA. The nucleotide sequences of all the exons and remaining splice junctions were identical to those of the normal DRB4 gene. The effect of the altered splice junction was evident from RNA blot analysis where inactivation of the normal splice site was found to result in a larger than normal DRB4 gene transcript. Thus, defective expression of the DRβIV protein results from incorrect processing of the mRNA from the DRB4-null allele.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00352841
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  • 2
    Digitale Medien
    Digitale Medien
    Transformation of white spruce and other conifer species byAgrobacterium tumefaciens (1989)
    Springer
    Plant cell reports 8 (1989), S. 16-20 
    Details
    ISSN: 1432-203X
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract Studies of the ability ofAgrobacterium to transform white spruce (Picea glauca), Engelmann spruce (P. engelmanni), Sitka spruce (P. sitchensis) and Douglas-fir (Pseudotsuga menziesii) showed frequencies of gall formation from 0–80% depending upon the strain ofAgrobacterium, and the conifer species. Thirty sixA. tumefaciens strains and oneA. rhizogenes strain were tested on 6 month old white spruce seedlings. NineA. tumefaciens strains induced gall formation on more than 50% of the inoculated trees and at greater than 10% of the inoculated sites. One strain, B2/74 gave rise to galls at 28% of the inoculated sites on white spruce and induced the highest overall frequency of gall formation on all the conifer species tested. Relative frequency of gall formation was consistent among species, although the overall frequency was much higher on Douglas-fir. Of the well characterized strains for which disarmed derivatives are available only A281 (carrying the supervirulent tumor inducing plasmid, pTiBo542) gave efficient transformation. Stable integration of T-DNA encoded genes has been confirmed by the expression of opine synthesis and hormone autonomous growth. The transfer and long-term stable expression of kanamycin resistance and firefly luciferase activity using binary vector systems was also achieved.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00735769
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  • 3
    Digitale Medien
    Digitale Medien
    Characterization of immature embryos of interior spruce by SDS-PAGE and microscopy in relation to their competence for somatic embryogenesis (1989)
    Springer
    Plant cell reports 8 (1989), S. 285-288 
    Details
    ISSN: 1432-203X
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract SDS-PAGE analysis of total proteins from cotyledonary embryo explants reveals that their competence to form somatic embryos is limited to a specific stage of development prior to the accumulation of storage proteins. When protein profiles of embryo explants of different open pollinated families from the same collection date are compared, there is a close relationship between the absence of storage proteins and their ability to produce embryogenic callus. In addition, the appearance of storage proteins in embryos from subsequent collections is associated with their loss of competence. Light microscopy combined with staining for total protein demonstrates that competent immature embryos have cotyledons but do not contain protein bodies.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00274131
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  • 4
    Digitale Medien
    Digitale Medien
    Occurrence and characteristics of unusual protistan symbionts from surgeonfishes (Acanthuridae) of the Great Barrier Reef, Australia (1989)
    Springer
    Marine biology 102 (1989), S. 403-412 
    Details
    ISSN: 1432-1793
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract The occurrence of unusual symbiotic microorganisms was examined in the intestines of a range of fish from the Great Barrier Reef, Australia. The fish taxa examined included 26 species of the family Acanthuridae, as well as representatives of phylogenetically related and herbivorous taxa. The microorganisms, referred to as protists, were only found in herbivorous and detritivorous members of the Acanthuridae. Protists were not found in planktivorous acanthurids, nor in any members of the families Kyphosidae, Pomacentridae, Scaridae, Zanclidae, Siganidae and Bleniidae we examined. In addition, protists were absent from the herbivorous acanthurids A. xanthopterus and A. nigricans. A range of protist forms, characterized by differences in size (8 to 417 μm), shape and mode of cell division (daughter-cell production and binary fission), was observed. The occurrence of these forms appeared to be correlated with host feedingecology. Large forms (〉100 μm) of the protists were only found in acanthurids which fed over hard-reef substrata. Smaller forms were found in sand-grazing and detritivorous species. One of the protist forms appears identical to protists previously reported from Red Sea acanthurids.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00428493
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  • 5
    Digitale Medien
    Digitale Medien
    Effect of laminar flow velocity on the kinetics of surface recolonization by Mot+ and Mot− Pseudomonas fluorescens (1989)
    Springer
    Microbial ecology 18 (1989), S. 1-19 
    Details
    ISSN: 1432-184X
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract Computer-enhanced microscopy (CEM) was used to monitor bacteria colonizing the inner surfaces of a 1×3 mm glass flow cell. Image analysis provided a rapid and reliable means of measuring microcolony count, microcolony area, and cell motility. The kinetics of motile and nonmotilePseudomonas fluorescens surface colonization were compared at flow velocities above (120μm sec−1) and below (8μm sec−1) the strain's maximum motility rate (85μm sec−1). A direct attachment assay confirmed that flagellated cells undergo initial attachment more rapidly than nonflagellated cells at high and low flow. During continuous-flow slide culture, neither the rate of growth nor the timing of recolonization (cell redistribution within surface microenvironments) were influenced by flow rate or motility. However, the amount of reattachment of recolonizing cells was both flow and motility dependent. At 8μm sec−1 flow, motility increased reattachment sixfold, whereas at 120μm sec−1 flow, motility increased reattachment fourfold. The spatial distribution of recolonizing cells was also influenced by motility. Motile cells dispersed over surfaces more uniformly (mean distance to the nearest neighbor was 47.0μm) than nonmotile cells (mean distance was 14.2μm) allowing uniform biofilm development through more effective redistribution of cells over the surface during recolonization. In addition, motile cell backgrowth (where cells colonize against laminar flow) occurred four times more rapidly than nonmotile cell backgrowth at low flow (where rate of motility exceeded flow), and twice as rapidly at high flow (where flow exceeded the rate of motility). The observed backgrowth of Mot+ cells against high flow could only have occurred as the result of motile attachment behavior. These results confirm the importance of motility as a behavioral mechanism in colonization and provides an explanation for enhanced colonization by motile cells in environments lacking concentration gradients necessary for chemotactic behavior.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02011692
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  • 6
    Digitale Medien
    Digitale Medien
    Localisation of islet amyloid peptide in lipofuscin bodies and secretory granules of human B-cells and in islets of type-2 diabetic subjects (1989)
    Springer
    Cell & tissue research 257 (1989), S. 179-185 
    Details
    ISSN: 1432-0878
    Schlagwort(e): Islet amyloid peptide ; Pancreatic islets ; Type-2 diabetes ; Insulin ; Lysosomes ; Secretory granules ; Man
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary Islet amyloid peptide (or diabetes-associated peptide), the major component of pancreatic islet amyloid found in type-2 diabetes, has been identified by electronmicroscopic immunocytochemistry in pancreatic B-cells from five non-diabetic human subjects, and in islets from five type-2 diabetic patients. The greatest density of immunoreactivity for islet amyloid peptide was found in electrondense regions of some lysosomal or lipofuscin bodies. The peptide was also localised by quantification of immunogold in the secretory granules of B-cells, and was present in cytoplasmic lamellar bodies. Acid phosphatase activity was also demonstrated in these organelles. Immunoreactivity for insulin was found in some lysosomes. These results suggest that islet amyloid peptide is a constituent of normal pancreatic B-cells, and accumulates in lipofuscin bodies where it is presumably partially degraded. In islets from type-2 diabetic subjects, amyloid fibrils and lipofuscin bodies in B-cells showed immunoreactivity for the amyloid peptide. Abnormal processing of the peptide within B-cells could lead to the formation of islet amyloid in type-2 diabetes.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00221649
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  • 7
    Digitale Medien
    Digitale Medien
    Contribution à la connaissance de la faune parasitaire d' Argentine, XV. Etude morphologique de Heteroxynema (Cavioxyura) viscaciae n. sp. (Nematoda, Heteroxynematidae) parasite de Lagidium viscacia boxi (Mammalia, Rodentia) (1989)
    Springer
    Systematic parasitology 13 (1989), S. 111-120 
    Details
    ISSN: 1573-5192
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Beschreibung / Inhaltsverzeichnis: Resumen Se describe a Heteroxynema (Cavioxyura) viscaciae n. sp. paràsito del ciego intestino grueso del rodeor Lagidium viscacia boxi Thomas. Esta nueva especie se asemeja a Heteroxynema (Cavioxyura) chiliensis Quentin, 1975, paràsito de Octodon degus (Molina) de Chile de la cual se diferencie esencialmente por sus medidas y por la disposicion de las papilas genitales del macho. El estudio de esta nueva especie muestra la existencia de: (i) un tipo poco frecuente en los Oxyuroidea de dimorfismo sexual a nivel de las estructuras bucales; (ii) cuatro pares de papilas genitales en el macho ubicadas proximas a relieves cuticulares que en otras especies pueden haber sido confundidos con terminaciones nerviosas suplementarias; (iii) de un gubernàculo y una espicula, organos raramente observables en los Heteroxynematidae, pero cuya presencia en otras especies del grupo pudo haber sido ignorada; (iv) de un sphincter particularmente diferenciado y desarollado.
    Kurzfassung: Abstract Heteroxynema (Cavioxyura) viscaciae n. sp., parasitic in the caecum and large intestine of Lagidium viscacia boxi Thomas, is described. The most closely related species is Heteroxynema (Cavioxyura) chiliensis Quentin, 1975, a parasite of Octodon degus (Molina) from Chile, from which the new species differs by its measurements and disposition of the male's genital papillae. Study of this new species shows the existence of: (i) a type of sexual dimorphism infrequent in the Oxyuroidea, at the level of the buccal structures; (ii) only four pairs of male genital papillae adjoining cuticular protuberances which in other species may have been confused with supplementary nerve endings; (iii) a gubernaculum and a spicule, structures infrequently observed in the Heteroxynematidae, and possibly overlooked or ignored in other species; (iv) a sphincter which is strongly differentiated and developed.
    Notizen: Résumé Heteroxynema (Cavioxyura) viscaciae n. sp., parasite du caecum et du gros intestin d'un rongeur caviomorphe d' Argentine, Lagidium viscacia boxi Thomas, est décrit. Cette nouvelle espèce est très proche de Heteroxynema (Cavioxyura) chiliensis Quentin, 1975, parasite d' Octodon degus (Molina) au Chili, dont elle se distingue essentiellement par ses mensurations et par la disposition de certaines papilles génitales des mâles. L'étude de cette nouvelle espèce montre l'existence: (i) au niveau des structures buccales d'un dimorphisme sexuel d'un type peu fréquent chez les Oxyuroidea; (ii) de quatre paires seulement de papilles génitales mâles voisinant avec des reliefs cuticulaires qui, dans d'autres espèces, ont peut-être été confondus avec des terminaisons nerveuses supplémentaires; (iii) d'un gubernaculum et d'un spicule, organes rarement observés chez les Heteroxynematidae, mais dont la présence dans d'autres espèces du groupe pourrait avoir été ignorée; (iv) au niveau de l'ovéjecteur, d'un sphincter particulièrement différencié et développé.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00015219
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  • 8
    Digitale Medien
    Digitale Medien
    Whole-field experimental displacement analysis of composite cylinders (1989)
    Springer
    Experimental mechanics 29 (1989), S. 58-62 
    Details
    ISSN: 1741-2765
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Maschinenbau
    Notizen: Abstract The lack of a quick, nondestructive method of flaw detection in composite materials is a hindrance to their use. Optical methods of determining displacements hold promise as a method of detection of these flaws. This paper illustrates the use of digital-image-processing equipment to determine the displacement fields in an internally pressurized composite cylinder. Included are results of actual experiments performed by the authors on both a Plexiglas and a composite cylinder.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02327782
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  • 9
    Digitale Medien
    Digitale Medien
    Phase II study of ifosfamide and mesna in patients with previously-treated carcinoma of the cervix (1989)
    Springer
    Investigational new drugs 7 (1989), S. 341-343 
    Details
    ISSN: 1573-0646
    Schlagwort(e): ifosfamide ; isofosfamide ; cervical cancer
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary Thirty patients with advanced squamous carcinoma of the uterine cervix recurrent after radiotherapy or surgery and refractory to first-line chemotherapeutic agents were treated with ifosfamide in a dose of 1.2 grams/m2 IV daily for five days every four weeks and Mesna 300 mg/m2 IV every four hours for three doses daily for five days. One patient had an inadequate trial and two were inevaluable for response, leaving 27 patients evaluable for response. All but two patients had received prior radiotherapy and all but one prior cisplatin-based or cisplatin analog chemotherapy. Seventeen patients had prior surgery. All patients were Gynecologic Oncology Group performance status 0, 1, or 2. Partial responses were observed in three patients (11.1%), two with pelvic and one with extrapelvic disease. A 90% confidence interval for the true response rate is 4.5%–24.8%. Severe (grade 3 or 4) leukopenia and anemia were seen in nine and seven patients, respectively. Severe thrombocytopenia was not observed. Three patients had grade 3 or 4 neurotoxicity, and one had grade 3 renal impairment. Reversible alopecia was universal. This dose and schedule of ifosfamide and Mesna is active in patients with squamous carcinoma of the cervix failing platinum-based therapy. Phase II testing in untreated patients is currently underway.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00173765
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  • 10
    Digitale Medien
    Digitale Medien
    A high precision dual feedback pump for unsteady perfusion of small organs (1989)
    Springer
    Annals of biomedical engineering 17 (1989), S. 269-278 
    Details
    ISSN: 1573-9686
    Schlagwort(e): Perfusion pump ; Feedback ; Steady ; Unsteady ; Pressure ; Flow
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin , Technik allgemein
    Notizen: Abstract A dynamic pump system is described for perfusion of small organs with whole blood. The pump system was designed with the following aims: Very low flowrates to perfuse single organs in small rodents; high dynamic response for pressure or flow to permit experimenting with a harmonic signal at frequencies up to 20 Hz or by way of sharp step transients in less than 10 msec; high precision to allow detection of fine physiological details, and minimum blood cell trauma or cell activation by use of a piston principle. Representative pressure-flow curves are shown for the rat gracilis muscle after vasodilation. The curves are highly reproducible and serve as a complimentary dataset for microvascular observations in the same organ.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02368046
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