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  • extinguishment  (2)
  • Life and Medical Sciences
  • pharmacokinetics
  • 1985-1989  (3)
  • 1930-1934
  • 1989  (3)
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Verlag/Herausgeber
Erscheinungszeitraum
  • 1985-1989  (3)
  • 1930-1934
Jahr
  • 1
    ISSN: 1572-8099
    Schlagwort(e): Flame ; extinguishment ; extinction ; diffusion flames ; dry chemicals ; hydrocarbon-air
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Architektur, Bauingenieurwesen, Vermessung
    Notizen: Abstract An extensive experimental study has been made of the extinguishment of a smalln-heptane diffusion flame (14.7 cm diameter pan) by five common dry-chemical powders—potassium bicarbonate, sodium bicarbonate, potassium chloride, monoammonium phosphate, and Monnex. The fire extinguishing effectiveness (reciprocal of the observed minimum extinction concentration) of each dry-chemical substance, other than that due to chemical specificity, is fully explained on the basis of particle size and distribution. Literature correlations between effectiveness and particle surface area appear to be incidental and stem from the inherent relationship between particle size and surface area. An important finding of the study is a discontinuity in the extinguishing effectiveness of a powder as a function of particle size. This occurs for each substance at a unique particle diameter above which there is a dramatic five-to eight-fold decrease in effectiveness. For a given substance, all powders with particle sizes below the limiting value exhibit the same maximum effectiveness.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Springer
    Fire technology 25 (1989), S. 195-212 
    ISSN: 1572-8099
    Schlagwort(e): physical ; thermal ; mechanisms ; flame ; fire ; extinguishment ; hydrocarbonair
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Architektur, Bauingenieurwesen, Vermessung
    Notizen: Abstract This paper presents an analysis of experimental flame and detonation extinguishment data published by a number of authors, including those in a companion paper. The maximum effectiveness observed for each of five common dry chemicals at small particle diameters is shown to be related to heat extraction from the flame by active endothermic sinks—heat capacity, fusion, vaporization, and decomposition. Larger particles are more stable in the flame and the reduced level of effectiveness observed is due principally to the only active sink—heat capacity. Evidence is presented to support two propositions: first, that the strong chemical inhibiting effects exhibited by many substances in flame velocity studies are effectively confined to low-concentration regimes; and second, that regardless of chemical effects, diffusion flames of the type studied are largely extinguished by thermal or heat extraction mechanisms at extinguishant concentrations that are quantitatively predicted by a simple heat balance and a predictable limit temperature.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    Springer
    European journal of clinical pharmacology 37 (1989), S. 75-77 
    ISSN: 1432-1041
    Schlagwort(e): dexamethasone ; congenital adrenal hyperplasia ; pharmacokinetics
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary The pharmacokinetics of dexamethasone, given at low dose, were studied in 13 patients with congenital adrenal hyperplasia (CAH) to ascertain whether kinetics differed in this inherited disorder of cortisol metabolism from those seen in healthy individuals. Changes in plasma dexamethasone concentration after intravenous bolus, measured using a simple novel radioimmunoassay, were well described by a two-compartment open model with first-order kinetics. Values for λ2: 0.206 h−1, t1/2: 3.53 h, Vc: 24.41 and f: 0.64 were similar to those previously reported for normal subjects. There were considerable interindividual differences in parameter values and Cmaxp.o. (range 22–67 nmol/l). As suppression of the hypothalamo-pituitary-adrenal axis correlates with plasma dexamethasone levels, this variability may partly explain the differing dose and dose schedule requirements necessary to achieve adequate therapeutic control in the clinical management of CAH.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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