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  • FLUID MECHANICS AND HEAT TRANSFER  (4)
  • extinguishment  (2)
  • Life and Medical Sciences
  • pharmacokinetics
  • 1985-1989  (7)
  • 1930-1934
  • 1989  (7)
Collection
Keywords
Publisher
Years
  • 1985-1989  (7)
  • 1930-1934
Year
  • 1
    ISSN: 1572-8099
    Keywords: Flame ; extinguishment ; extinction ; diffusion flames ; dry chemicals ; hydrocarbon-air
    Source: Springer Online Journal Archives 1860-2000
    Topics: Architecture, Civil Engineering, Surveying
    Notes: Abstract An extensive experimental study has been made of the extinguishment of a smalln-heptane diffusion flame (14.7 cm diameter pan) by five common dry-chemical powders—potassium bicarbonate, sodium bicarbonate, potassium chloride, monoammonium phosphate, and Monnex. The fire extinguishing effectiveness (reciprocal of the observed minimum extinction concentration) of each dry-chemical substance, other than that due to chemical specificity, is fully explained on the basis of particle size and distribution. Literature correlations between effectiveness and particle surface area appear to be incidental and stem from the inherent relationship between particle size and surface area. An important finding of the study is a discontinuity in the extinguishing effectiveness of a powder as a function of particle size. This occurs for each substance at a unique particle diameter above which there is a dramatic five-to eight-fold decrease in effectiveness. For a given substance, all powders with particle sizes below the limiting value exhibit the same maximum effectiveness.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Fire technology 25 (1989), S. 195-212 
    ISSN: 1572-8099
    Keywords: physical ; thermal ; mechanisms ; flame ; fire ; extinguishment ; hydrocarbonair
    Source: Springer Online Journal Archives 1860-2000
    Topics: Architecture, Civil Engineering, Surveying
    Notes: Abstract This paper presents an analysis of experimental flame and detonation extinguishment data published by a number of authors, including those in a companion paper. The maximum effectiveness observed for each of five common dry chemicals at small particle diameters is shown to be related to heat extraction from the flame by active endothermic sinks—heat capacity, fusion, vaporization, and decomposition. Larger particles are more stable in the flame and the reduced level of effectiveness observed is due principally to the only active sink—heat capacity. Evidence is presented to support two propositions: first, that the strong chemical inhibiting effects exhibited by many substances in flame velocity studies are effectively confined to low-concentration regimes; and second, that regardless of chemical effects, diffusion flames of the type studied are largely extinguished by thermal or heat extraction mechanisms at extinguishant concentrations that are quantitatively predicted by a simple heat balance and a predictable limit temperature.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 37 (1989), S. 75-77 
    ISSN: 1432-1041
    Keywords: dexamethasone ; congenital adrenal hyperplasia ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of dexamethasone, given at low dose, were studied in 13 patients with congenital adrenal hyperplasia (CAH) to ascertain whether kinetics differed in this inherited disorder of cortisol metabolism from those seen in healthy individuals. Changes in plasma dexamethasone concentration after intravenous bolus, measured using a simple novel radioimmunoassay, were well described by a two-compartment open model with first-order kinetics. Values for λ2: 0.206 h−1, t1/2: 3.53 h, Vc: 24.41 and f: 0.64 were similar to those previously reported for normal subjects. There were considerable interindividual differences in parameter values and Cmaxp.o. (range 22–67 nmol/l). As suppression of the hypothalamo-pituitary-adrenal axis correlates with plasma dexamethasone levels, this variability may partly explain the differing dose and dose schedule requirements necessary to achieve adequate therapeutic control in the clinical management of CAH.
    Type of Medium: Electronic Resource
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  • 4
    Publication Date: 2019-06-28
    Description: A detailed study was made of face and annular seals under conditions where boiling, i.e., phase change of the leaking fluid, occurs within the seal. Many seals operate in this mode because of flashing due to pressure drop and/or heat input from frictional heating. High pressure, water pumps, industrial chemical pumps, and cryogenic pumps are mentioned as a few of many applications. The initial motivation was the LOX-GOX seals for the space shuttle main engine, but the study was expanded to include any face or annular seal where boiling occurs. Some of the distinctive behavior characteristics of two-phase seals were discussed, particularly their axial stability. While two-phase seals probably exhibit instability to disturbances of other degrees of freedom such as wobble, etc., under certain conditions, such analyses are too complex to be treated at present. Since an all liquid seal (with parallel faces) has a neutral axial stiffness curve, and is stabilized axially by convergent coning, other degrees of freedom stability analyses are necessary. However, the axial stability behavior of the two-phase seal is always a consideration no matter how well the seal is aligned and regardless of the speed. Hence, axial stability is thought of as the primary design consideration for two-phase seals and indeed the stability behavior under sub-cooling variations probably overshadows other concerns. The main thrust was the dynamic analysis of axial motion of two-phase face seals, principally the determination of axial stiffness, and the steady behavior of two-phase annular seals. The main conclusions are that seals with two-phase flow may be unstable if improperly balanced. Detailed theoretical analyses of low (laminar) and high (turbulent) leakage seals are presented along with computer codes, parametric studies, and in particular a simplified PC based code that allows for rapid performance prediction. A simplified combined computer code for the performance prediction over the laminar and turbulent ranges of a two-phase seal is described and documented. The analyses, results, and computer codes are summarized.
    Keywords: FLUID MECHANICS AND HEAT TRANSFER
    Type: NASA-CR-4256 , E-4999 , NAS 1.26:4256
    Format: application/pdf
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  • 5
    Publication Date: 2019-07-13
    Description: Adding to the classical Hellinger-Reissner formulation, a residual form of the equilibrium equation, a new Galerkin/least-squares finite element method is derived. It fits within the framework of a mixed finite element method and is stable for rather general combinations of stress and velocity interpolations, including equal-order discontinuous stress and continuous velocity interpolations which are unstable within the Galerkin approach. Error estimates are presented based on a generalization of the Babuska-Brezzi theory. Numerical results (not presented herein) have confirmed these estimates as well as the good accuracy and stability of the method.
    Keywords: FLUID MECHANICS AND HEAT TRANSFER
    Type: International Conference on Finite Element Methods in Flow Problems; Apr 03, 1989 - Apr 07, 1989; Huntsville, AL; United States
    Format: text
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  • 6
    Publication Date: 2019-07-13
    Description: Symmetric finite-element formulations are presented for the primitive-variables form of the Stokes equations. These formulations are convergent for any combination of pressure and velocity interpolations. Various boundary conditions, such as pressure, are accommodated.
    Keywords: FLUID MECHANICS AND HEAT TRANSFER
    Type: International Conference on Finite Element Methods in Flow Problems; Apr 03, 1989 - Apr 07, 1989; Huntsville, AL; United States
    Format: text
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  • 7
    Publication Date: 2019-07-13
    Description: The application of Galerkin/least-squares methodology to computational fluid dynamics is reviewed. Applications to advective-diffusive systems of equations and incompressible and compressible Euler and Navier-Stokes equations are described. Space-time finite-element methodology for time-dependent problems is emphasized and the status and role of so-called 'discontinuity-capturing operators' is reviewed.
    Keywords: FLUID MECHANICS AND HEAT TRANSFER
    Type: International Conference on Finite Element Methods in Flow Problems; Apr 03, 1989 - Apr 07, 1989; Huntsville, AL; United States
    Format: text
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