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RNAi screening identifies mediators of NOD2 signaling: Implications for spatial specificity of MDP recognition (2012)

Lipinski, S. ; Grabe, N. ; Jacobs, G. ; [weitere]

National Academy of Sciences

In: PNAS - Proceedings of the National Academy of Sciences of the United States of America. 2012; 109(52): 21426-21431. Published 2012 Dec 03. doi: 10.1073/pnas.1209673109.

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Publikationsdatum: 2012-12-03

Print ISSN: 0027-8424

Digitale ISSN: 1091-6490

Thema: Biologie , Medizin , Allgemeine Naturwissenschaft

Publiziert von National Academy of Sciences

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Trimethylated homoserine functions as the major compatible solute in the globally significant oceanic cyanobacteriumTrichodesmium (2016)

Pade, Nadin ; Michalik, Dirk ; Ruth, Wolfgang ; [weitere]

National Academy of Sciences

In: PNAS - Proceedings of the National Academy of Sciences of the United States of America. 2016; 113(46): 13191-13196. Published 2016 Oct 31. doi: 10.1073/pnas.1611666113.

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Publikationsdatum: 2016-10-31

Beschreibung: The oceanic N2-fixing cyanobacteriumTrichodesmiumspp. form extensive surface blooms and contribute significantly to marine carbon and nitrogen cycles in the oligotrophic subtropical and tropical oceans.Trichodesmiumgrows in salinities from 27 to 43 parts per thousand (ppt), yet its salt acclimation strategy remains enigmatic because the genome ofTrichodesmium erythraeumstrain IMS101 lacks all genes for the biosynthesis of any known compatible solute. Using NMR and liquid chromatography coupled to mass spectroscopy, we identified the main compatible solute inT. erythraeumstrain IMS101 as the quaternary ammonium compoundN,N,N-trimethyl homoserine (or homoserine betaine) and elucidated its biosynthetic pathway. The identification of this compatible solute explains howTrichodesmiumspp. can thrive in the marine system at varying salinities and provides further insight into the diversity of microbial salt acclimation.

Print ISSN: 0027-8424

Digitale ISSN: 1091-6490

Thema: Biologie , Medizin , Allgemeine Naturwissenschaft

Publiziert von National Academy of Sciences

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Corrigendum: Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer (2016)

Khaled Ali; Dalya R. Soond; Roberto Piñeiro; Thorsten Hagemann; Wayne Pearce; Ee Lyn Lim; Hicham Bouabe; Cheryl L. Scudamore; Timothy Hancox; Heather Maecker; Lori Friedman; Martin Turner; Klaus Okkenhaug; Bart Vanhaesebroeck

Springer Nature

In: Nature

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Publikationsdatum: 2016-07-28

Beschreibung: Corrigendum: Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer Nature 535, 7613 (2016). doi:10.1038/nature17641 Authors: Khaled Ali, Dalya R. Soond, Roberto Piñeiro, Thorsten Hagemann, Wayne Pearce, Ee Lyn Lim, Hicham Bouabe, Cheryl L. Scudamore, Timothy Hancox, Heather Maecker, Lori Friedman, Martin Turner, Klaus Okkenhaug & Bart Vanhaesebroeck Nature510, 407–411 (2014); doi:10.1038/nature13444Queen Mary University London notified Nature and University College London that there is reason to question the provenance of the data for Fig. 5b, d, e of this Letter (Fig. 5a, c

Print ISSN: 0028-0836

Digitale ISSN: 1476-4687

Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik

Publiziert von Springer Nature

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PII-like signaling protein SbtB links cAMP sensing with cyanobacterial inorganic carbon response (2018)

Selim, Khaled A. ; Haase, Florian ; Hartmann, Marcus D. ; [weitere]

National Academy of Sciences

In: PNAS - Proceedings of the National Academy of Sciences of the United States of America. 2018; 115(21): E4861-E4869. Published 2018 May 07. doi: 10.1073/pnas.1803790115.

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Publikationsdatum: 2018-05-07

Beschreibung: Cyanobacteria are phototrophic prokaryotes that evolved oxygenic photosynthesis ∼2.7 billion y ago and are presently responsible for ∼10% of total global photosynthetic production. To cope with the evolutionary pressure of dropping ambient CO2 concentrations, they evolved a CO2-concentrating mechanism (CCM) to augment intracellular inorganic carbon (Ci) levels for efficient CO2 fixation. However, how cyanobacteria sense the fluctuation in Ci is poorly understood. Here we present biochemical, structural, and physiological insights into SbtB, a unique PII-like signaling protein, which provides new insights into Ci sensing. SbtB is highly conserved in cyanobacteria and is coexpressed with CCM genes. The SbtB protein from the cyanobacterium Synechocystis sp. PCC 6803 bound a variety of adenosine nucleotides, including the second messenger cAMP. Cocrystal structures unraveled the individual binding modes of trimeric SbtB with AMP and cAMP. The nucleotide-binding pocket is located between the subunit clefts of SbtB, perfectly matching the structure of canonical PII proteins. This clearly indicates that proteins of the PII superfamily arose from a common ancestor, whose structurally conserved nucleotide-binding pocket has evolved to sense different adenyl nucleotides for various signaling functions. Moreover, we provide physiological and biochemical evidence for the involvement of SbtB in Ci acclimation. Collectively, our results suggest that SbtB acts as a Ci sensor protein via cAMP binding, highlighting an evolutionarily conserved role for cAMP in signaling the cellular carbon status.

Print ISSN: 0027-8424

Digitale ISSN: 1091-6490

Thema: Biologie , Medizin , Allgemeine Naturwissenschaft

Publiziert von National Academy of Sciences

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Engineering control of bacterial cellulose production using a genetic toolkit and a new cellulose-producing strain (2016)

Florea, Michael ; Hagemann, Henrik ; Santosa, Gabriella ; [weitere]

National Academy of Sciences

In: PNAS - Proceedings of the National Academy of Sciences of the United States of America. 2016; 113(24): E3431-E3440. Published 2016 May 31. doi: 10.1073/pnas.1522985113.

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Publikationsdatum: 2016-05-31

Beschreibung: Bacterial cellulose is a strong and ultrapure form of cellulose produced naturally by several species of theAcetobacteraceae. Its high strength, purity, and biocompatibility make it of great interest to materials science; however, precise control of its biosynthesis has remained a challenge for biotechnology. Here we isolate a strain ofKomagataeibacter rhaeticus(K. rhaeticusiGEM) that can produce cellulose at high yields, grow in low-nitrogen conditions, and is highly resistant to toxic chemicals. We achieved external control over its bacterial cellulose production through development of a modular genetic toolkit that enables rational reprogramming of the cell. To further its use as an organism for biotechnology, we sequenced its genome and demonstrate genetic circuits that enable functionalization and patterning of heterologous gene expression within the cellulose matrix. This work lays the foundations for using genetic engineering to produce cellulose-based materials, with numerous applications in basic science, materials engineering, and biotechnology.

Print ISSN: 0027-8424

Digitale ISSN: 1091-6490

Thema: Biologie , Medizin , Allgemeine Naturwissenschaft

Publiziert von National Academy of Sciences

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Engineering bacterial cellulose with genetic tools [Microbiology] (2016)

Florea, M., Hagemann, H., Santosa, G., Abbott, J., Micklem, C. N., Spencer-Milnes, X., de Arroyo Garcia, L., Paschou, D., Lazenbatt, C., Kong, D., Chughtai, H., Jensen, K., Freemont, P. S., Kitney, R., Reeve, B., Ellis, T.

National Academy of Sciences

In: PNAS - Proceedings of the National Academy of Sciences

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Publikationsdatum: 2016-06-15

Beschreibung: Bacterial cellulose is a strong and ultrapure form of cellulose produced naturally by several species of the Acetobacteraceae. Its high strength, purity, and biocompatibility make it of great interest to materials science; however, precise control of its biosynthesis has remained a challenge for biotechnology. Here we isolate a strain of...

Print ISSN: 0027-8424

Digitale ISSN: 1091-6490

Thema: Biologie , Medizin , Allgemeine Naturwissenschaft

Publiziert von National Academy of Sciences

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7

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FRMPD2 directs basolateral NOD2 signaling [Immunology] (2012)

Lipinski, S., Grabe, N., Jacobs, G., Billmann–Born, S., Till, A., Hasler, R., Aden, K., Paulsen, M., Arlt, A., Kraemer, L., Hagemann, N., Erdmann, K. S., Schreiber, S., Rosenstiel, P.

National Academy of Sciences

In: PNAS - Proceedings of the National Academy of Sciences

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Publikationsdatum: 2012-12-27

Beschreibung: The intracellular nucleotide-binding oligomerization domain-2 (NOD2) receptor detects bacteria-derived muramyl dipeptide (MDP) and activates the transcription factor NF-κB. Here we describe the regulatome of NOD2 signaling using a systematic RNAi screen. Using three consecutive screens, we identified a set of 20 positive NF-κB regulators including the known pathway members RIPK2,...

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Digitale ISSN: 1091-6490

Thema: Biologie , Medizin , Allgemeine Naturwissenschaft

Publiziert von National Academy of Sciences

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PII-like signaling protein SbtB links cAMP sensing with cyanobacterial inorganic carbon response [Microbiology] (2018)

Khaled A. Selim, Florian Haase, Marcus D. Hartmann, Martin Hagemann, Karl Forchhammer

National Academy of Sciences

In: PNAS - Proceedings of the National Academy of Sciences

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Publikationsdatum: 2018-05-23

Beschreibung: Cyanobacteria are phototrophic prokaryotes that evolved oxygenic photosynthesis ∼2.7 billion y ago and are presently responsible for ∼10% of total global photosynthetic production. To cope with the evolutionary pressure of dropping ambient CO2 concentrations, they evolved a CO2-concentrating mechanism (CCM) to augment intracellular inorganic carbon (Ci) levels for efficient CO2...

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Digitale ISSN: 1091-6490

Thema: Biologie , Medizin , Allgemeine Naturwissenschaft

Publiziert von National Academy of Sciences

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9

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Effects of tumor treating fields (TTFields) on glioblastoma cells are augmented by mitotic checkpoint inhibition (2018)

Kessler, Almuth F. ; Frömbling, Greta E. ; Gross, Franziska ; [weitere]

Springer Nature

In: Cell Death Discovery. 2018; 4(1): 77. Published 2018 Jul 16. doi: 10.1038/s41420-018-0079-9.

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Publikationsdatum: 2018-07-16

Digitale ISSN: 2058-7716

Thema: Biologie , Medizin

Publiziert von Springer Nature

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Trimethylated homoserine functions as the major compatible solute in the globally significant oceanic cyanobacterium Trichodesmium [Microbiology] (2016)

Nadin Pade, Dirk Michalik, Wolfgang Ruth, Natalia Belkin, Wolfgang R. Hess, Ilana Berman-Frank, Martin Hagemann

National Academy of Sciences

In: PNAS - Proceedings of the National Academy of Sciences

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Publikationsdatum: 2016-11-16

Beschreibung: The oceanic N2-fixing cyanobacterium Trichodesmium spp. form extensive surface blooms and contribute significantly to marine carbon and nitrogen cycles in the oligotrophic subtropical and tropical oceans. Trichodesmium grows in salinities from 27 to 43 parts per thousand (ppt), yet its salt acclimation strategy remains enigmatic because the genome of Trichodesmium...

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Digitale ISSN: 1091-6490

Thema: Biologie , Medizin , Allgemeine Naturwissenschaft

Publiziert von National Academy of Sciences

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