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  • GEOPHYSICS  (168)
  • Animals  (127)
  • Life and Medical Sciences  (120)
  • Cell & Developmental Biology  (109)
  • INSTRUMENTATION AND PHOTOGRAPHY  (48)
  • 1985-1989  (463)
  • 1988  (463)
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Keywords
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  • 1985-1989  (463)
Year
  • 1
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    The 8 February 1986 magnetospheric compression event - Observations of simultaneous magnetospheric leakage and specularly reflected solar wind ions (1988)
    In:  Other Sources
    Details
    Publication Date: 2011-08-19
    Description: Multi-satellite observations of energetic particle were made during the magnetospheric compression event of February 8, 1986. In the upstream region in the interplanetary medium (IPM) observations were made of magnetospheric leakage particles and specularly reflected solar wind ions.
    Keywords: GEOPHYSICS
    Type: Advances in Space Research (ISSN 0273-1177); 8; 9-10,
    Format: text
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    NASA TECHNICAL REPORTS
  • 2
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    Concerted nonsyntenic allelic loss in human colorectal carcinoma (1988)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1988-08-19
    Description: Familial polyposis coli (FPC) is caused by an autosomal dominant gene on chromosome 5, and it has been proposed that colorectal cancer in the general population arises from loss or inactivation of the FPC gene, analogous to recessive tumor genes in retinoblastoma and Wilms' tumor. Since allelic loss can be erroneously scored in nonhomogeneous samples, tumor cell populations were first microdissected from 24 colorectal carcinomas, an additional nine cancers were engrafted in nude mice, and nuclei were flow-sorted from an additional two. Of 31 cancers informative for chromosome 5 markers, only 6 (19%) showed loss of heterozygosity of chromosome 5 alleles, compared to 19 of 34 (56%) on chromosome 17, and 17 of 33 (52%) on chromosome 18. Therefore, it appears that (i) FPC is a true dominant for adenomatosis but not a common recessive gene for colon cancer; and (ii) simple Mendelian models involving loss of alleles at a single locus may be inappropriate for understanding common human solid tumors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Law, D J -- Olschwang, S -- Monpezat, J P -- Lefrancois, D -- Jagelman, D -- Petrelli, N J -- Thomas, G -- Feinberg, A P -- New York, N.Y. -- Science. 1988 Aug 19;241(4868):961-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, University of Michigan Medical School, Ann Arbor 48109.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2841761" target="_blank"〉PubMed〈/a〉
    Keywords: Adenocarcinoma/genetics ; Adenoma/genetics ; Adenomatous Polyposis Coli/*genetics ; *Alleles ; Animals ; Chromosomes, Human, Pair 17 ; Chromosomes, Human, Pair 18 ; Chromosomes, Human, Pair 5 ; Colonic Neoplasms/*genetics ; DNA, Neoplasm/analysis ; Genes, Dominant ; *Genetic Linkage ; Humans ; Mice ; Precancerous Conditions/genetics ; Rectal Neoplasms/*genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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    PAPER CURRENT
  • 3
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    Human IL-3 and GM-CSF act synergistically in stimulating hematopoiesis in primates (1988)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1988-09-30
    Description: Interleukin-3 (IL-3) is a member of a family of growth factors, each of which supports the proliferation and development of hematopoietic precursors in culture. Although the biologic effects of the different hematopoietic growth factors have been well documented in different culture systems, it has only recently become possible to study the activities of these molecules in vivo. In comparison with the later acting hematopoietic growth factors granulocyte-macrophage colony-stimulating factor (GM-CSF) and granulocyte colony-stimulating factor, IL-3 elicited a delayed and relatively modest leukocytosis when continuously infused intravenously in primates. The IL-3 infusion, however, greatly potentiated the responsiveness of the animal to subsequent administration of a low dose of GM-CSF. These results suggest that IL-3 expands an early cell population in vivo that subsequently requires the action of a later acting factor such as GM-CSF to complete its development. Optimal stimulation of hematopoiesis may be achieved with combinations of hematopoietic growth factors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Donahue, R E -- Seehra, J -- Metzger, M -- Lefebvre, D -- Rock, B -- Carbone, S -- Nathan, D G -- Garnick, M -- Sehgal, P K -- Laston, D -- RR00168/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1988 Sep 30;241(4874):1820-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Genetics Institute, Cambridge, MA 02140.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3051378" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Colony-Stimulating Factors/*pharmacology ; Drug Synergism ; Granulocyte-Macrophage Colony-Stimulating Factor ; Growth Substances/*pharmacology ; Hematopoiesis/*drug effects ; Interleukin-3/*pharmacology ; Leukocyte Count ; Macaca fascicularis ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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    PAPER CURRENT
  • 4
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    The CDAW-8 substorm event on 28 January 1983 - A detailed global study (1988)
    In:  Other Sources
    Details
    Publication Date: 2011-08-19
    Description: A small, isolated substorm with an expansion phase onset at 0739 UT on January 28, 1983 was well observed by ground-based instrumentation as well as by low- and high-altitude spacecraft. Because of the comprehensive nature of the data coverage, including ISEE-3 identification of plasmoid signatures in the deep tail (about 220 earth radii) associated with the substorm, a detailed timeline of the growth, expansion, and recovery phases of the substorm can be provided. The plasma, energetic particle, and field signatures at ISEE-3 are considered within the framework of the near-earth data. Quantitative estimates of substorm energy input and output relationships are made for this case, and the timing and physical dimensions of the deep tail disturbance implied are evaluated by the global observations available.
    Keywords: GEOPHYSICS
    Type: Advances in Space Research (ISSN 0273-1177); 8; 9-10,; 113-115
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  • 5
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    The radial and longitudinal propagation characteristics of substorm injections (1988)
    In:  Other Sources
    Details
    Publication Date: 2019-07-12
    Description: This paper presents a statistical study of the radial and azimuthal propagation of substorm effects in the near-geosynchronous magnetotail. Data from five spacecraft (AMPTE/CCE, 1979-053, 1982-019, GOES-5, and GOES-6) have been used in the study. Since CCE has an apogee of 8.8 earth radii, those data allow for the study of both the radial and azimuthal propagation characteristics of substorm events. A list of ion injections was compiled from CCE energetic particle data obtained in 1985 and 1986. Those injections are dispersionless over an energy range of 25 to 285 keV on a 72-sec time scale. Dispersionless injections during which 1979-053 or 1982-019 were on the nightside in close longitudinal proximity to CCE were selected for the study. The most significant correlation in the data is between the local time separation between any two spacecraft and the time delay between the local onsets.
    Keywords: GEOPHYSICS
    Type: Advances in Space Research (ISSN 0273-1177); 8; 9-10; 91-95
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    NASA TECHNICAL REPORTS
  • 6
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    An observation of atmospheric gravity wave cause and effect during October 1985 WAGS campaign (1988)
    In:  Other Sources
    Details
    Publication Date: 2019-07-12
    Description: Moderate geomagnetic activity followed by a large scale TID was observed in Europe and eastern North America near 1200 UT on October 18, 1985 during the Worldwide Atmospheric Gravity Wave Study. The speed and direction of the TID are estimated, suggesting that it was caused by an atmospheric gravity wave expanding from a localized source over the Arctic Ocean. Auroral imaging shows that the source region was located near the westward edge of an expanding auroral bulge and may have been associated with a westward traveling surge. The TID periods increased with distance from the source region and the largest TID amplitudes were seen along a line perpendicular to the orientation of the auroral oval.
    Keywords: GEOPHYSICS
    Type: Radio Science (ISSN 0048-6604); 23; 919-930
    Format: text
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    NASA TECHNICAL REPORTS
  • 7
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    Studies of high latitude mesospheric turbulence by radar and rocket. II - Measurements of small scale turbulence (1988)
    In:  Other Sources
    Details
    Publication Date: 2019-07-12
    Description: Measurements of mesospheric small scale turbulence and associated larger scale wave structures were obtained from rocket probe flights during equinox in spring 1985. The measurements were verified by data from the mesosphere-stratosphere-troposphere radar at Poker Flat, Alaska. Electron density irregularities down to an altitude of about 62 km and fluctuations in positive ion density in the altitude region from 50 to 90 km were measured. Turbulence in the inertial subrange was observed at heights where the fluctuations generally were largest. Measurement of background electron density exhibited gradients relative to the monotonically increasing density profile, suggesting the presence of large amplitude wave motions transporting the plasma by mixing. The radar detected the occurrence of 1-3 km wavelike perturbations superimposed on a 7-km wave in the wind velocity field. It is suggested that the 1-3 km waves are more important in the transport of energy and momentum and in the production of turbulence in the lower mesosphere.
    Keywords: GEOPHYSICS
    Type: Journal of Atmospheric and Terrestrial Physics (ISSN 0021-9169); 50; 963-976
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    NASA TECHNICAL REPORTS
  • 8
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    Auroral energy deposition rate, characteristic electron energy, and ionospheric parameters derived from Dynamics Explorer 1 images (1988)
    In:  Other Sources
    Details
    Publication Date: 2019-07-12
    Description: Auroral images obtained by the Spin Scan Auroral Imager (SAI) aboard the DE-1 satellite were used to derive auroral energy deposition rate, characteristic electron energy, and ionospheric parameters. The principles involved in the imaging technique and the physical mechanisms that underlie the relationship between the spectral images and the geophysical parameters are discussed together with the methodology for implementing such analyses. It is shown that images obtained with the SAI provide global parameters at 12-min temporal resolution; the spatial resolution is limited by the field of view of a pixel. The analysis of the 12-min images presented yielded a representation of ionospheric parameters that was better than can be obtained using empirical models based on local measurements averaged over long periods of time.
    Keywords: GEOPHYSICS
    Type: Journal of Geophysical Research (ISSN 0148-0227); 93; 12841-12
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    NASA TECHNICAL REPORTS
  • 9
    Electronic Resource
    Electronic Resource
    A polypeptide growth inhibitor isolated from lactating bovine mammary gland (MDGI) is a lipid-carrying protein (1988)
    New York, N.Y. : Wiley-Blackwell
    Journal of Cellular Biochemistry 38 (1988), S. 199-204 
    Details
    ISSN: 0730-2312
    Keywords: fatty acid-binding protein ; mechanism of action ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Mammary-derived growth inhibitor (MDGI), a polypeptide growth inhibitor isolated from lactating bovine mammary tissue, previously shown to have extensive sequence homology with fatty acid-binding proteins, was demonstrated to meet the criteria of a fatty acid-binding protein. The protein was found to bind [3H]palmitic acid in a saturable manner and to be complexed with endogeneous free fatty acids. [3H]palmitic acid, when bound to the protein, was more rapidly taken up by the target cells (human mammary carcinoma cells [MaTu]) than was free [3H]palmitic acid, suggesting a lipid carrier function for the inhibitor. It is suggested that the fatty acid-binding properties of MDGI may relate to its ability to inhibit cell growth in vitro and to regulate other cellular functions.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcb.240380307
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  • 10
    Electronic Resource
    Electronic Resource
    Electrophoretic analysis of four high molecular weight sialoglycoproteins produced by metastatic human colon carcinoma cells (1988)
    New York, N.Y. : Wiley-Blackwell
    Journal of Cellular Biochemistry 37 (1988), S. 1-9 
    Details
    ISSN: 0730-2312
    Keywords: colon cancer ; metastasis ; mucins ; electrophoresis ; lectins ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: We have found that polyacrylamide gel electrophoresis in 3% gels in the presence of sodium dodecyl sulfate is suitable for the separation of cellular glycoproteins having molecular weights ranging from 200,000 to 1,000,000. The gels secured on a rigid support (Gelbond) allow blotting techniques with lectins and antibodies for the detection of glycoproteins. Using these methods we have separated lysates of HT-29 human colon carcinoma cells and detected at Jeast four distinct high molecular weight Sialoglycoproteins having molecular weights of 900,000, 740.000, 560,000, and 450,000. The expression of the 9000,000 component, as revealed by wheat germ agglutinin binding, was much higher in a subline of HT-29 cells established from liver metastases in a nude mouse than it was in the parental cells. The relative intensity of wheat germ agglutinin binding to these four sialoglycoprotein components differs depending upon their growth phase in vitro. These glycoproteins were also detectable by the binding of peanut agglutinin, provided the glycoproteins were previously treated in the gels with mild acid to remove the sialic acid from their carbohydrate chains, suggesting that mucin-type carbohydrate chains are present on these glycoproteins. The same set of glycoproteins can be detected by metabolic labeling of the cells with [3H] glucosamine in tissue culture. Very similar glycoprotein profiles are revealed by metabolic labeling of fresh colon carcinoma tissues with [3H] glucosamine in vitro.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcb.240370102
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