Publication Date:
1988-05-20
Description:
Alpha particles are energetic short-range ions whose higher linear energy transfer produces extreme cytotoxicity. An alpha-particle-emitting radioimmunoconjugate consisting of a bismuth-212-labeled monoclonal immunoglobulin M specific for the murine T cell/neuroectodermal surface antigen Thy 1.2 was prepared. Analysis in vitro showed that the radioimmunoconjugate was selectively cytotoxic to a Thy 1.2+ EL-4 murine tumor cell line. Approximately three bismuth-212-labeled immunoconjugates per target cell reduced the uptake of [3H]thymidine by the EL-4 target cells to background levels. Mice inoculated intraperitoneally with EL-4 cells were cured of their ascites after intraperitoneal injection of 150 microcuries of the antigen-specific radioimmunoconjugate, suggesting a possible role for such conjugates in intracavitary cancer therapy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Macklis, R M -- Kinsey, B M -- Kassis, A I -- Ferrara, J L -- Atcher, R W -- Hines, J J -- Coleman, C N -- Adelstein, S J -- Burakoff, S J -- 5 PO1-CA39542-03/CA/NCI NIH HHS/ -- 5T32 CA 09536-01/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1988 May 20;240(4855):1024-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Joint Center for Radiation Therapy, Harvard Medical School, Boston, MA 02115.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2897133" target="_blank"〉PubMed〈/a〉
Keywords:
*Alpha Particles
;
Animals
;
*Antigens, Surface
;
Antigens, Thy-1
;
Bismuth/therapeutic use
;
*Immunoglobulin M
;
Immunotherapy
;
Lymphoma/*radiotherapy
;
Mice
;
Mice, Inbred C57BL
;
Radioisotopes/therapeutic use
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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