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  • Analytical Chemistry and Spectroscopy  (128)
  • Biochemistry and Biotechnology  (50)
  • Inorganic Chemistry  (24)
  • AERODYNAMICS
  • Aircraft Stability and Control
  • GENERAL
  • Wiley-Blackwell  (202)
  • 1985-1989  (202)
  • 1988  (202)
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Keywords
Publisher
  • Wiley-Blackwell  (202)
Years
  • 1985-1989  (202)
Year
  • 1
    Electronic Resource
    Electronic Resource
    Large-scale production of monoclonal antibodies in suspension culture (1988)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 32 (1988), S. 993-1000 
    Details
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Monoclonal antibodies are being manufactured for clinical trials in suspension culture at the 1300-L scale. Suspension culture offers some advantages relative to high-density mammalian cell culture methods; in particular, the ability to closely monitor the behavior of cells in a homogeneous environment. Computer control and on-line mass spectrography of exit gases provide instantaneous information about the culture metabolic activity. Air sparging and agitation by marine impeller provide aeration sufficient to maintain a constant dissolved oxygen tension at cell concentrations up to 5.0 × 106 cells/mL without causing apparent cell damage.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260320807
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  • 2
    Electronic Resource
    Electronic Resource
    A microfibril-generating factor from the cellulase of Trichoderma reesei (1988)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 31 (1988), S. 321-327 
    Details
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: A combination of ionic strength reduction and diafiltration of Trichoderma reesei cellulate complex through a hollow fiber apparatus of 5000 molecular weight (MW) cutoff and subsequent passage of filtrate over a Spherogel-TSK 3000-SW column provided extracts that had the ability to generate microfibrils in filter paper and to disrupt filter paper and corn leaf tissue. Milligram quantities of material obtained from these extracts released small amounts of soluble carbohydrate from filter paper, required ferric iron for increased activity, and contained amino acids. Short fiber formation and disruption of filter paper during interaction with these extracts was enhanced by prior acid treatment and eliminated by prior base treatment. The amount of soluble carbohydrate hydrolyzed in 24 h from filter paper by whole cellulase complex was not changed by first disrupting the substrate with the extracts.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260310407
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  • 3
    Electronic Resource
    Electronic Resource
    Analyse Vibrationnelle et Structurale en Série Aliphatique Saturee. VIIIPour l'article VII dans cette série, voir J. L. Delarbre, L. Maury et L. Bardet, J. Raman Spectrosc. 16, 288 (1985). - Spectres de Vibration de l'acide Glutarique et de ses Sels Alcalins en Solution Aqueuse (1988)
    Chichester [u.a.] : Wiley-Blackwell
    Journal of Raman Spectroscopy 19 (1988), S. 167-174 
    Details
    ISSN: 0377-0486
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: The Raman and infrared spectra of glutaric acid, (CH2)3[COOH(D)]2, and its potassium salts, CH2)3(COO2KHD and CH23COO2K2, in aqueous solution have been investigated in the range 3500-200 cm-1. The analysis of the polarization ratio of the Raman lines indicated that glutaric acid belongs to point group C1 whereas its ions belong to point group Cs. An assignment of the fundamental vibrations is proposed.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jrs.1250190305
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  • 4
    Electronic Resource
    Electronic Resource
    Distinction of α- and β-aspartyl and α- and γ-glutamyl peptides by fast atom bombardment/tandem mass spectrometry (1988)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 15 (1988), S. 399-402 
    Details
    ISSN: 0887-6134
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A fast atom bombardment/collisional activation/linked-scan at constant B/E (tandern mass spectrometric) method is described which can distinguish between α- and β-aspartyl and α- and μ-glutamyl underivatized peptides. The method is based upon differences in loss of CO from aspartyl or glutamyl B-fragment ions (IB) in these isomers which are rationalized from the stability of the resultant A-fragment ions (IA). It was observed that the ratio of IB:IA which was used in this determination was dependent upon the collision cell pressure. The higher the collision cell pressure, the larger the difference between the IB: IA ratios for these linkages.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200150707
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  • 5
    Electronic Resource
    Electronic Resource
    Characterization of doxylamine and pyrilamine metabolites via thermospray/mass spectrometry and tandem mass spectrometry (1988)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 15 (1988), S. 501-508 
    Details
    ISSN: 0887-6134
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Analysis of doxylamine N-oxide and pyrilamine N-oxide as synthetic standards and biologically derived metabolites by thermospray mass spectrometry (TSP/MS) provided [M + H]+ ions for each metabolite. TSP/tandem mass spectrometry (TSP/MS/MS) of the [M + H]+ ions provided fragment ions characteristic of these metabolites. In addition, TSP mass spectrometry and TSP/MS/MS analysis of ring-hydroxylated N-desmethyldoxylamine, N-desmethylpyrilamine and O-dealkylated pyrilamine is also reported. A fragmentation pathway for analysis by MS/MS of pyrilamine and its metabolites is also proposed. The results demonstrate the utility of TSP/MS for biologically derived metabolites of pyrilamine and doxylamine.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200150907
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  • 6
    Electronic Resource
    Electronic Resource
    Preparation and activity of carbonic anhydrase immobilized on porous silica beads and graphite rods (1988)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 31 (1988), S. 796-801 
    Details
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Techniques for the immobilization of bovine carbonic anhydrase (BCA) on porous silica beads and graphite are presented. Surface coverage on porous silica beads was found to be 1.5 × 10-5 mmol BCA/m2, and on graphite it was 1.7 × 10-3 mmol BCA/m2 nominal surface area. Greater than 97% (silica support) and 85% (graphite support) enzyme activity was maintained upon storage of the immobilized enzyme for 50 days in pH 8 buffer at 4°C. After 500 days storage, the porous silica bead immobilized enzyme exhibited over 70% activity. Operational stability of the enzyme on silica at 23°C and pH 8 was found to be 50% after 30 days. Catalytic activity expressed as an apparent second-order rate constant K′Enz for the hydrolysis of p-nitrophenyl acetate (p-NPA) catalyzed by BCA immobilized on silica beads and graphite at pH 8 and 25°C is 2.6 × 102 and 5.6 × 102 M-1s-1 respectively. The corresponding KENZ value for the free enzyme is 9.1 × 102 M-1s-1. Activity of the immobilized enzyme was found to vary with pH in such a manner that the active site pK, on the porous silica bead support is 6.75, and on graphite it is 7.41. Possible reasons for a microenvironmental influence on carbonic anhydrase pKa, are discussed. Comparison with literature data shows that the enzyme surface coverage on silica beads reported here is superior to previously reported data on silica beads and polyacrylamide gels and is comparable to an organic matrix support. Shifts in BCA-active site pKa values with support material, a lack of pH dependent activity studies in the literature, and differing criteria for reporting enzyme activity complicate literature comparisons of activity; however, immobilized BCA reported here generally exhibits comparable or greater activity than previous reports for immobilized BCA.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260310806
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  • 7
    Electronic Resource
    Electronic Resource
    Static coating of phenyl and biphenyl polysiloxane stationary phases on small-diameter capillary columns (1988)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 11 (1988), S. 113-118 
    Details
    ISSN: 0935-6304
    Keywords: Static coating ; Biphenyl polysiloxane ; Capillary columns ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Static coating of phenyl and biphenyl polysiloxane stationary phases on 50 μm i.d. open tubular capillaries was studied. The influence of coating solvents and coating temperatures on the viscosities and surface tensions of the polymer stationary phases and their coating solutions was determined. A measure of the Rayleigh instability paralled the observed coating efficiencies.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jhrc.1240110129
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  • 8
    Electronic Resource
    Electronic Resource
    GC/MS characterization of urinary metabolites of doxylamine succinate: Identification of the aglycones formed from intestinal microflora metabolism of the polar glucuronide metabolites (1988)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 11 (1988), S. 517-520 
    Details
    ISSN: 0935-6304
    Keywords: Capillary GC ; Mass spectrometry ; GC/MS ; Doxylamine metabolites ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: This study describes the use of high performance liquid chromatography (HPLC) and capillary gas chromatography/mass spectrometry (GC/MS) in the characterization of polar glucuronide conjugates of doxylamine and their subsequent aglycones following deconjugation. Rat urinary extracts which contained doxylamine and both nonconjugated and conjugated doxylamine metabolites, were examined by HPLC before and after incubation with rat intestinal microflora. The subsequent deconjugated urinary metabolites and the nonconjugated products remaining in the urinary extracts were then isolated, acetylated, and assayed by GC/MS. Incubation with the intestinal microflora indicated that anaerobic bacteria were capable of effecting hydrolytic cleavage of these polar O-glucuronide metabolites of doxylamine and its demethylated products to their subsequent aglycones. GC/MS analysis was performed using a fused silica DB-5 GC column and was utilized for the identification of these deconjugated metabolites.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jhrc.1240110704
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  • 9
    Electronic Resource
    Electronic Resource
    Novel fused silica capillary columns: Surface modification through controlled doping of the preform-tube (1988)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 11 (1988), S. 395-400 
    Details
    ISSN: 0935-6304
    Keywords: Gas chromatography (GC) ; Fused silica ; Column technology ; Surface modification ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A method has been developed for fabricating fused silica capillary columns which have specific surface properties but still retain the excellent strength, flexibility, and resilience of pure fused silica. By using the Modified Chemical Vapor Deposition process (MCVD), typically used for the production of optical fiber lightguides, inorganic dopants such as Al, Nd, Ge, and P can be introduced into the preform-tube by MCVD. Doped columns have a wide range of specific surface properties, and columns with undoped fused silica prepared by MCVD are more chemically inert and less acidic than columns prepared by conventional methods. This paper describes the method for fabricating capillaries and the initial studies to characterize them.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jhrc.1240110507
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  • 10
    Electronic Resource
    Electronic Resource
    Obtaining structural information of perfluoro-1,3-dimethyladamantane from collisionally activated decomposition mass spectra (1988)
    New York, NY : Wiley-Blackwell
    Rapid Communications in Mass Spectrometry 2 (1988), S. 204-206 
    Details
    ISSN: 0951-4198
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Physics
    Notes: Cyclic, high molecular weight perfluorocarbons (PFC's) are very electronegative, and can be detected by methane negative ion chemical ionization (NICI); however only molecular ions are detected. Electron ionization (EI) of PFC's, on the other hand, yields little or no molecular ion but very intense low mass fragment ions such as CF3+ (m/z 69), C3F5+ (m/z 131) and C4F7+ (m/z 181), which are not structurally characteristic. High-energy collisionally activated decomposition (CAD) of positive, molecular ions of perfluoro-1,3-dimethyladamantane yields important structural information by providing more intense high mass fragment ions. Fragments of the following formulae and abundances (in brackets): C5F11+ (100), C11F17+ (73), C7F9+ (67), C8F11+ (43), C4F7+ (26), C7F8+. (18), and CF3+ (14) are detected by this method.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/rcm.1290021005
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