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  • Articles  (4)
  • Polymer and Materials Science  (2)
  • furosemide  (2)
  • dopamine  (1)
  • 1985-1989  (4)
  • 1890-1899
  • 1988  (4)
  • 1
    Electronic Resource
    Electronic Resource
    A Quantitative Method of Evaluating the Diuretic Response to Furosemide in Rats (1988)
    Springer
    Pharmaceutical research 5 (1988), S. 694-698 
    Details
    ISSN: 1573-904X
    Keywords: furosemide ; diuresis ; sodium excretion ; potassium excretion ; chloride excretion ; urinary excretion rate ; urinary electrolytes in rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Furosemide effects are usually evaluated by measuring the urinary excretion rate of Na+ (UVNa) in humans. In the present study, however, UVNa showed a nonlinear relationship with urine flow rate after intravenous injection of furosemide in rats. In contrast, when the urinary excretion rate of (Na+ + K+) (UVNa+K) was plotted against the urine flow rate, a linear regression line was observed, with small interindividual variations in normal rats and in rats with uranyl nitrate-induced acute renal failure (ARF). Piretanide, a loop diuretic, also showed a similar relationship, while other types of diuretics revealed different slope values for the relationship. Although the urinary excretion rate of Cl− (UVC1) vs UVNa+K is expected to show a linear relationship in normal rats, the correlation coefficient of the linear regression line was smaller than that of the urine flow rate vs UVNa+K. Further, the slope of UVC1 vs UVNa+K was slightly different in ARF rats. Therefore, UVNa+K provides a better quantitative measure of diuretic response to loop diuretics than UVNa or UVC1.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1015999626133
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  • 2
    Electronic Resource
    Electronic Resource
    Structural and energetic parameters of Ca2+ binding to peptides and proteins (1988)
    New York : Wiley-Blackwell
    Biopolymers 27 (1988), S. 1865-1886 
    Details
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The characteristics of Ca2+-binding sites and of the structural reorganization induced by Ca2+-binding in storage proteins and ion carriers are being studied as models for molecular mechanisms in Ca2+ channels and in Ca2+-dependent modulatory proteins. A first step in the study was the development of energy parameters for Ca2+ compatible with those in the CHARMM package of computer simulation software. Such parameters were obtained from an analytical fit to the potential surface for [(Ca)(OCH2)4]2+ calculated with an ab initio molecular orbital method. The resulting parametrization was tested for the hexapeptide cyclo-(Pro-Gly)3, and a 75 residue long calcium binding protein from bovine intestine (ICaBP). The geometrical parameters calculated for the hexapeptide and its 2:1 complex with Ca2+ were in good agreement with experimental data from crystallography and nmr. Similarly, the structure of ICaBP optimized with CHARMM using the new Ca2+ parameters showed good agreement with the x-ray structure both in the local structures of the calcium-binding sites and in the overall shape of the protein.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bip.360271202
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  • 3
    Electronic Resource
    Electronic Resource
    Urinary Excretion and Diuretic Action of Furosemide in Rats: Increased Response to the Urinary Excretion Rate of Furosemide in Rats with Acute Renal Failure (1988)
    Springer
    Pharmaceutical research 5 (1988), S. 699-703 
    Details
    ISSN: 1573-904X
    Keywords: furosemide ; acute renal failure ; increased response ; urinary excretion of furosemide ; dopamine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract A urinary excretion–response curve representing the urinary excretion rate of furosemide versus the urinary excretion rate of (Na+ + K+) was used to analyze furosemide action in rats with uranyl nitrate-induced acute renal failure (ARF) with and without dopamine coadministration. Urinary excretion of furosemide, but not its serum concentration, was the determinant for the diuretic action of furosemide. Increased diuretic response was observed in ARF rats, although the total diuretic response and urinary recovery of furosemide within 2 hr decreased. Dopamine enhanced furosemide-induced diuresis in ARF rats in terms of the total urine output and urinary electrolyte excretion, although the urinary excretion–response curves were not different. This enhancement by dopamine was found to be caused by the augmented urinary excretion of furosemide and the increased response to this drug in ARF rats. These findings suggest the contribution of decreased concentrating ability along the nephron and/or increased sensitivity of cells at the site of action to this drug.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1015951710204
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  • 4
    Electronic Resource
    Electronic Resource
    Ionic products in ground polymer. IV. Anions in poly(vinylidene fluoride) (1988)
    Bognor Regis [u.a.] : Wiley-Blackwell
    Journal of Polymer Science Part B: Polymer Physics 26 (1988), S. 1307-1312 
    Details
    ISSN: 0887-6266
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: When poly(vinylidene fluoride) (PVDF) was ground with tetracyanoethylene (TCNE) powder in a vibration glass ball mill in vacuum in the dark at 77 K, the TCNE anion radical (TCNE-) was detected in the mixture by ESR spectroscopy. The TCNE.- is formed by the abstraction of electrons by TCNE from the anion that is produced by a heterogeneous bond scission of carbon-carbon bonds in the polymer main chain. The assignment of TCNE.- was carried out by the ESR spectral simulation on the basis of an anisotropic effective hyperfine tensor that includes a forbidden transition term. At least 85% of the bond scission of the PVDF main chain is induced by a heterogeneous process to produce ionic products. The yield of these mechanions seems to increase with the polarity of carbon-carbon bond owing to a substituent group bonded to the carbon in the polymer main chain.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/polb.1988.090260614
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