ISSN:
1573-904X
Keywords:
Oxyphencyclimine
;
enantiomers
;
anticholinergic
;
antimuscarinic activity
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract The (R)-( + )- and (S)-( – )-enantiomers of the anticholinergic compound, oxyphencyclimine, were synthesized from (R)-( – )- and (S)-( + )-2-cyclohexyl-2-hydroxy-2-phenylethanoic acid, respectively. The potencies of the enantiomers were compared using a cholinergic receptor binding assay. The (R)-( + )-enantiomer inhibited binding 29 times more potently than the (S)-( – )-enantiomer.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1015945830309
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