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  • etintidine  (2)
  • FLUID MECHANICS AND HEAT TRANSFER  (1)
  • Inorganic Chemistry  (1)
  • 1985-1989  (4)
  • 1987  (4)
  • 1
    Electronic Resource
    Electronic Resource
    A High-Performance Liquid Chromatographic Microassay Employing a Liquid–Solid Extraction Technique for Etintidine in Plasma (1987)
    Springer
    Pharmaceutical research 4 (1987), S. 133-136 
    Details
    ISSN: 1573-904X
    Keywords: etintidine ; high-performance liquid chromatography (HPLC) ; solid extraction ; determination of etintidine in plasma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract This paper describes a new, rapid solid extraction method for the determination of etintidine in plasma. The method employs a semiautomatic sample preparation system. Plasma samples and the internal standard (cimetidine) were applied onto octyl-bonded silica extraction columns. The extraction columns were then subjected to Tris buffer and water wash and were subsequently loaded onto an automatic sample injection system. The contents of the extraction columns were eluted on-line with a mobile phase of acetonitrile:methanol:0.1% ammonium hydroxide (85:10:5, by volume) onto a silica analytical column and detected by UV absorption at 229 nm. The chromatographic condition separates etintidine from some of its metabolites and other endogenous components in plasma. The detection limit for etintidine was 0.02–0.05 µg/ml when 0.2 ml of plasma was used. This method has been used for the determination of plasma etintidine levels in humans and mice after oral administration of etintidine and was found to be suitable for pharmacokinetic/bioavailability studies of etintidine in humans and animals. The method can also be used for the quantitative determination of cimetidine and certain metabolites of etintidine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1016419019715
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Etintidine-propranolol interaction study in humans (1987)
    Springer
    Journal of pharmacokinetics and pharmacodynamics 15 (1987), S. 557-568 
    Details
    ISSN: 1573-8744
    Keywords: etintidine ; propranolol ; 4-hydroxypropranolol ; interaction ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Etintidine HCl is a potent H2 -blocker. The effect of clinical doses of etintidine on the disposition of a single oral dose of propranolol was investigated in 12 normal subjects. This was a double-blind, two-way crossover study. Each subject received etintidine (400 mg) or placebo twice a day with meals for 4 days on two occasions (separated by 4 days). On each occasion, the subjects were fasted overnight on Day 3 and were given an oral dose of Inderal® (40 mg propranolol hydrochloride) 30 min following the administration of the morning dose of etintidine or placebo on Day 4. Blood samples were collected prior to and up to 24 hr following the administration of propranolol. The plasma samples were analyzed for propranolol and 4-hydroxypropranolol by HPLC. Comparison of the pharmacokinetic parameters of propranolol between etintidine and the placebo groups indicates that etintidine significantly increased the AUC0−∞,values (573.5 vs. 146.4 ng·hr/ml, p=0.0001)and prolonged the elimination half-life (4.61 vs. 2.33 hr) of propranolol. Statistical evaluation of the pharmacokinetic parameters of 4-hydroxypropanolol indicates that etintidine also increased the AUC0−24 values (43.8 vs. 16.4 ng·hr/ml, p=0.0028) and prolonged the elimination half-life (4.87 vs. 1.97 hr) of 4-hydroxypropranolol. The data suggest that etintidine, like cimetidine, impaired the elimination of propranolol. Etintidine also protracted the elimination of 4-hydroxypropranolol, an active metabolite of propranolol.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01068412
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  • 3
    Electronic Resource
    Electronic Resource
    NMR-spektroskopische Untersuchungen an Fluoro-diaza-diphosphetidinen und Fluoro-λ5-monophosphazenen (1987)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 544 (1987), S. 225-231 
    Details
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: N.M.R. Investigations of Fluorodiazadiphosphetidines and Fluoro-λ5-monophosphazenesThe 19F and 31P n.m.r. data of 37 fluorodiazadiphosphetidines [RR′PF—NC6H4X]2, and 62 fluoro-λ5-monophosphazenes, RR′PF=NC6H4X, are submitted. In the case of tetrafluorodiazadiphosphetidines, [RPF2—NC6H4X]2, an intramolecular exchange of the fluorine atoms at phosphorus has to be concluded from the n.m.r. data. The influence of the substituents R and X on the n.m.r. parameters is discussed using simple models of molecular structure.
    Notes: Es werden die 19F- und 31P-NMR-Daten von 37 Fluorodiazadiphosphetidinen, [RR′PF—NC6H4X]2, und 62 Fluoro-λ5-monophosphazenen, RR′PF=NC6H4X, mitgeteilt. Aus ihnen muß für die Tetrafluorodiazadiphosphetidine, [RPF2—NC6H4X]2, auf einen intramolekularen Positionswechsel der Fluoratome am Phosphor geschlossen werden. Der Einfluß der Substituenten R und X auf die NMR-Parameter wird anhand einfacher Modelle der Molekülstruktur diskutiert.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19875440124
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  • 4
    facet.materialart.
    Unknown
    Numerical experiments on boundary-layer receptivity (1987)
    In:  Other Sources
    Details
    Publication Date: 2011-08-19
    Description: The incompressible laminar flow over an infinitely thin flat plate is obtained using a Navier-Stokes code in vorticity-velocity variables. The flow at and near the leading edge of the plate is an integral part of the solution algorithm which requires no special treatment; thus allowing for the flow field in this region to be studied in detail. An incident plane sound wave is imposed in the free-stream flow and the receptivity of the boundary layer is studied with particular emphasis to the flow near and at the leading edge.
    Keywords: FLUID MECHANICS AND HEAT TRANSFER
    Format: text
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