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  • Analytical Chemistry and Spectroscopy  (19)
  • Chemical Engineering  (6)
  • 1985-1989  (25)
  • 1970-1974
  • 1987  (25)
Collection
Keywords
Publisher
Years
  • 1985-1989  (25)
  • 1970-1974
Year
  • 1
    Electronic Resource
    Electronic Resource
    Monitoring the behaviour of 4-ketocyclophosphamide versus cyclophosphamide during capillary gas chromatography by mass spectrometry (1987)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 14 (1987), S. 643-647 
    Details
    ISSN: 0887-6134
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Capillary Gas Chromatography (CGC) is capable of determining underivatized cyclophosphamide (CPA) using SCOT OV 275 columns. Then CPA is subjected to in situ degradation resulting in formation of a cyclization product which can be determined selectively in biological fluids. In routine bioanalysis however cyclization products of CPA metabolites might interfere, e.g. 4-keto CPA. In the present study possible formation of cyclization products of 4-keto CPA similar to CPA was monitored by Mass Spectrometry. Cyclization of 4-keto CPA in situ was demonstrated to occur, resulting in a product similar to that of CPA. Both cyclization products could be determined selectively and it appeared that in situ cyclization of 4-keto CPA was negligible (〈5%), probably owing to extra stabilization of the CPA metabolite by keto-enol tautomerism as has been demonstrated by NMR.
    Additional Material: 14 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200141113
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  • 2
    Electronic Resource
    Electronic Resource
    Melt flow behavior of blends from poly(vinyl chloride) and epoxidized natural rubber (1987)
    Brookfield, Conn. : Wiley-Blackwell
    Journal of Vinyl and Additive Technology 9 (1987), S. 161-167 
    Details
    ISSN: 0193-7197
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Blends from poly(vinyl chloride) (PVC) and epoxidized natural rubber (ENR) were prepared in a Brabender plasticorder by the melt blending technique. The melt flow behavior of these blends with respect to blend ratio and temperature has been examined using a melt flow indexer and capillary rheometer. ENR decreases the Brabender torque, increases the melt flow index (MFI), and decreases the melt viscosity of PVC in the blends. Arrhenius plots were used to study the effect of temperature on melt flow index (MFI) and viscosity. Moreover, the flow behavior index (n′) obtained from capillary rheometer data was found to be dependent on temperature and blend ratio.
    Additional Material: 11 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/vnl.730090406
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  • 3
    Electronic Resource
    Electronic Resource
    Measurement of tulobuterol in human plasma by capillary gas chromatography and selected ion monitoring detection (1987)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 14 (1987), S. 613-616 
    Details
    ISSN: 0887-6134
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A method is described for the quantification of tulobuterol in human plasma, based upon selective extraction and high resolution capillary gas chromatography-mass spectrometry. The mass spectrometric determination is based on selected ion monitoring of two fragment ions derived from the N,O-heptafluorobutyryl derivatives of tulobuterol and its internal standard, deschlorotulobuterol. The plasma work-up procedure consists of extraction of 1.0 ml alkalinised plasma with dichloromethane, back-extraction into an acidified aqueous phase, followed by a final extraction with dichloromethane after realkalinisation. The method gave interference-free and linear results. The between-assay variability is 4.7% CV at the 3.0 μg l-1 plasma concentration level. The assay permitted quantitative measurements down to 170 ng tulobuterol per litre of plasma and hence provided sufficient sensitivity for quantification of plasma levels after therapeutic doses.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200141107
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  • 4
    Electronic Resource
    Electronic Resource
    Selected ion monitoring analysis of monoamine metabolites in cerebrospinal fluid. Application to the study of in vivo effects of α2-antagonists (1987)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 14 (1987), S. 675-682 
    Details
    ISSN: 0887-6134
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The technique of isotope dilution mass spectrometry has been used for the measurement of biogenic amine metabolites in cerebrospinal fluid (CSF). CSF samples were collected from rabbits treated with α2-antagonists. The aim of our study was to determine the specificity of these drugs on the central nervous noradrenergic, dopaminergic and serotonergic activity as measured by the release of corresponding monoamine metabolites. 3-Methoxy-4-hydroxyphenylethylene glycol (MHPG) and vanilmandelic acid (VMA) were used as parameters for the noradrenergic activity, whereas homovanillic acid (HVA) and 5-hydroxyindole-3-acetic acid (5-HIAA) were employed to follow the dopaminergic and serotonergic activity, respectively. For the measurement of the biogenic amine metabolites a published GCMS method has been adapted. Samples of 200 μl CSF were processed. Following addition of deuterated internal standards and acidification, extraction was carried out with ethyl acetate. Preliminary experiments with the analysis of MHPG using diethyl ether for extraction gave rise to emulsion formation and resulted in poor recoveries for MHPG and in irreproducibility problems due to a preferential extraction of non-labelled MHPG, effects which were not observed with ethyl acetate extraction. Derivatization was done with a mixture of pentafluoropropionic anhydride/pentafluoropropanol (or hexafluoroisopropanol) in order to derivatize both hydroxyl and carboxylic acid groups. The derivatization procedure was optimized for the analysis of 5-HIAA by carrying out a second reaction step with pentafluoropropionic anhydride alone in order to complete the derivatization for the indolic NH moiety. The molecular ions of the derivatized products were selected for detection. The methodology has been applied to evaluate the effects of two α2-antagonists, i.e. yohimbine and idazoxan. Yohimbine was found to increase the CSF levels of the noradrenergic metabolites MHPG and VMA and of the dopaminergic metabolite HVA and to have serotonergic effects, whereas idazoxan was shown to exhibit noradrenergic effect only.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200141119
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  • 5
    Electronic Resource
    Electronic Resource
    Quantitative determination of rimantadine in human plasma and urine by GC-MS (1987)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 14 (1987), S. 549-553 
    Details
    ISSN: 0887-6134
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A GC-MS procedure has been developed for the quantitation in plasma and urine of rimantadine, an antiviral drug effective against type A influenza. The assay utilizes selective ion monitoring, methane negative ion chemical ionization (NCI) and stable isotope dilution. Sensitivity to NCI is effected by derivation of rimantadine with pentafluorobenzoyl chloride. The method has been used to quantitate plasma concentrations of rimantadine over a range from 4.2 ng/ml to 416 ng/ml, and urinary concentrations of rimantadine over a range of 21 ng/ml to 2077 ng/ml.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200141004
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  • 6
    Electronic Resource
    Electronic Resource
    Guest editorial (1987)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 14 (1987), S. 589-589 
    Details
    ISSN: 0887-6134
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200141102
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  • 7
    Electronic Resource
    Electronic Resource
    Phase holdups in three-phase fluidized beds (1987)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 33 (1987), S. 1359-1370 
    Details
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The local bubble frequency, the local phase holdups and the local bed porosity in three-phase fluidized beds were measured. Air, water, and 250 μm glass beads were used as the gas, liquid, and solid phases. The effects of gas and liquid velocities on phase holdups were studied. Time-averaged local gas holdup and bubble frequency were measured by an optical fiber probe. Mass balances were performed at various axial positions along the fluidized beds to check the accuracy of the measurements.
    Additional Material: 12 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aic.690330813
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  • 8
    Electronic Resource
    Electronic Resource
    Effective thermal conductivity in a packed-bed radial-flow reactor (1987)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 33 (1987), S. 1747-1750 
    Details
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aic.690331021
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  • 9
    Electronic Resource
    Electronic Resource
    Crystallization kinetics of potassium chloride from brine and scale-up criterion (1987)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 33 (1987), S. 1690-1697 
    Details
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: A systematic study of potassium chloride crystallization shows that constant tip speed, TIPS, is the agitation criterion for scale-up. Three hydrodynamic regions are identified by a group MT TIPS3. Thus, a new generalized kinetic equation is proposed: B° = KGi(MT TIPS)j.The values of the power index j are 0.7 and 1.2 for low and high ranges of MT TIPS3, respectively. At even higher MT TIPS3, j scatters due to the breakage of crystals. The power index i is independent of hydrodynamic conditions and depends only on the crystallization temperature, e.g., it is 2.8 at 313.2 K.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aic.690331012
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  • 10
    Electronic Resource
    Electronic Resource
    Evaluation of dead time calculation in liquid chromatography using a linearization procedure for homologous series (1987)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 10 (1987), S. 191-200 
    Details
    ISSN: 0935-6304
    Keywords: Liquid chromatography, HPLC ; Dead time calculation ; Homologous series ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A mathematical method for the calculation of the dead time (tm) in HPLC was evaluated using a computer simulation approach, in which artificial perturbations were introduced to Simulated homolog retention times. The calculation was based on a modified and extended Grobler and Bálisz (GB) method. Investigated wav how the precision of the calculated tM is affected by: statistical fluctuations in retention times and which, and how many homolog retention times are used. Based on these simulations a two-step procedure for the tM calculation is proposed: In the first step the linearity of log tR, n vs carbon number n is checked using as many homolog retention times as possible. The slope value bo of the first linear regression in the GB method is used for the selection of homolog retention times in the final tM calculation. In the second step the optimal selection of homologs is made and the final tM calculation is carried out. Guidelines for homolog selection are given.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jhrc.1240100407
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